Horan, Alexandra M’s team published research in Organic Letters in 2021-12-03 | 3921-01-5

Organic Letters published new progress about Coupling reaction. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Synthetic Route of 3921-01-5.

Horan, Alexandra M.; Duong, Vincent K.; McGarrigle, Eoghan M. published the artcile< Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts>, Synthetic Route of 3921-01-5, the main research area is bis heteroaryl preparation; halopyridine pyridylsulfonium salt coupling reaction.

Herein ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts I (R = H, Br, Me, trifluoromethyl; R1 = H, OMe, CN, Br, etc.; R2 = H, trifluoromethyl; R3 = H, Me; R2R3 = -(CH=CH-CH=CH)-) and phenyl(pyrimidin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate are reported. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages including 2,4′-bipyridines, 2,3′-bipyridines, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes II (R4 = 2-fluoropyridin-4-yl, pyrazin-2-yl, dimethyl-1,2-oxazol-4-yl, 1-benzothiophen-2-yl, etc.). The methodol. was successfully applied to the synthesis of the natural products caerulomycin A and E.

Organic Letters published new progress about Coupling reaction. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Synthetic Route of 3921-01-5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pontillo, Joseph’s team published research in Bioorganic & Medicinal Chemistry Letters in 2005-10-01 | 4956-05-2

Bioorganic & Medicinal Chemistry Letters published new progress about Gonadotropin-releasing hormone receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Electric Literature of 4956-05-2.

Pontillo, Joseph; Guo, Zhiqiang; Wu, Dongpei; Struthers, R. Scott; Chen, Chen published the artcile< Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor>, Electric Literature of 4956-05-2, the main research area is gonadotropin releasing hormone receptor antagonist aryl triazinedione preparation; aza uracil triazinedione preparation preparation gonadotropin releasing hormone receptor.

Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3,5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure-activity relationships of the monocyclic compounds One compound was identified as potent gonadotropin-releasing hormone receptor antagonist from this series.

Bioorganic & Medicinal Chemistry Letters published new progress about Gonadotropin-releasing hormone receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Electric Literature of 4956-05-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Watatani,Mitsuo’s team published research in Takamine Kenkyusho Nenpo in 1960 | 3286-55-3

Takamine Kenkyusho Nenpo published new progress about Alcoholysis. 3286-55-3 belongs to class pyrimidines, and the molecular formula is C5H6ClN3O, Product Details of C5H6ClN3O.

Nakazawa, Junichi; Watatani, Mitsuo published the artcile< Pyrimidine derivatives. I. Sulfanilamide derivatives>, Product Details of C5H6ClN3O, the main research area is .

4-Sulfanilamido-2,6-disubstituted pyrimidines were prepared A mixture of 3.8 g. 2,6-dihydroxypyrimidine, 38 cc. POCl3, and 9 g. PhNMe2 was refluxed 2 hrs., excess of POCl3 removed, the residue decomposed with ice, the mixture adjusted to pH 2.8, and kept overnight to give 3.9 g. 2,6-dichloro-4-aminopyrimidine (I), needles, m. 270-1° (MeOH). A mixture of 16.3 g. 2-methoxy-4-amino-6-hydroxypyrimidine, 23.6 g. Ac2O, and 23.6 g. AcOH was refluxed 1 hr. to give 19.3 g. 2-methoxy-4-acetamido-6-hydroxypyrimidine (II), m. 275-80° (decomposition). Similarly was prepared 2-ethoxy-4-acetamido-6-hydroxypyrimidine (needles, m. 258-9° (decomposition) (EtOH)). A mixture of II (9 g.) 30.2 POCl3, and 6 g. PhNMe2 was refluxed 1.5 hrs., the excess of POCl3 removed, and the residue decomposed with ice to give 8.6 g. 2-methoxy-4-acetamido-6-chloropyrimidine (III), columns, m. 197-8° (AcOEt). Similarly was prepared 2-ethoxy-4-acetamido-6-chloropyrimidine, columns, m. 193° (C6H6 or AcOEt). III (13 g.) was heated 10 min. with 5.2 g. NaOH and 200 cc. 90% MeOH, the whole neutralized, the MeOH removed, H2O added, and the resulting crystals recrystallized from C6H6 to give 9.1 g. 2-methoxy-4-amino-6-chloropyrimidine (IV), needles, m. 128-9°. Similarly was prepared 2-ethoxy-4-amino-6-chloropyrimidine, needles, m. 128-9° (C6H6). I (1.7 g.) was refluxed 4 hrs. with 1.2 g. NaOH and 12 cc. MeOH, the mixture, filtered, the filtrate concentrated, and H2O added to give 1.5 g. 2,6-dimethoxy-4-aminopyrimidine (V), columns, m. 151-2° (C6H6). Refluxing III or IV with NaOH in MeOH also gave V in 90% yield. Similarly were prepared the following 2,6-RR’ derivatives of 4-aminopyrimidines (R, R’, m.p., and % yield given): OEt, OEt, 107-8°, 95.3; SMe, SMe, 122-3°, 91.6; SEt, SEt, 78-80°, 84; OEt, OMe, 107-8.5°, -; OPh, OMe, 137-8°, 59.9; SMe, OMe, 94-5°, 54.5; SEt, OMe, 78-80°, 52.1; OMe, OEt, 142-3°, 87.6; OEt, SEt, (b1.5 165-9°), 87.3; SPh, OEt, 108.5-9.5°, 70.2. A solution of 4.4 g. V and 7.3 g. 4-acetylsulfanilyl chloride in 14.6 g. C5H5N was kept at room temperature overnight, heated 1 hr. on a steam bath with 73 cc. 10% NaOH solution, H2O added and the mixture evaporated in vacuo, the residue adjusted to pH 4 with HCl, and the resulting crystals recrystallized from MeOH to give 7.8 g. 4-sulfanilamido-2,6-dimethoxypyrimidine, columns, m. 201-2°. Similarly were prepared the following N:C(R).N:C(R’).CH:CNHSO2C6H4NH2-p (data as before): OEt, OEt, 195-6°, 77.8; SMe, SMe, 178-9°, 74.1; SEt, SEt, 178-9°, 79.7; OMe, OEt, -, -; OMe, OPh, 108-10°, 51.4; OMe, SMe, 172-3°, 71.6; OMe, SEt, 175-6°, 73.0; OEt, OMe, 185-6°, 77.9; SEt, OEt, 177-8°, 46.2; OEt, SPh, 206-8°, 61.5.

Takamine Kenkyusho Nenpo published new progress about Alcoholysis. 3286-55-3 belongs to class pyrimidines, and the molecular formula is C5H6ClN3O, Product Details of C5H6ClN3O.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Yu, Lide’s team published research in Molecules in 2019 | 18740-39-1

Molecules published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Electric Literature of 18740-39-1.

Yu, Lide; Wang, Qinqin; Wang, Caolin; Zhang, Binliang; Yang, Zunhua; Fang, Yuanying; Zhu, Wufu; Zheng, Pengwu published the artcile< Design, Synthesis and biological evaluation of novel thienopyrimidine derivatives as PI3Kα inhibitors>, Electric Literature of 18740-39-1, the main research area is morpholinyl diphenyldihydropyrazolyl thienopyrimidine preparation; diphenyldihydropyrazolyl morpholinyl tetrahydrobenzothienopyrimidine preparation; antitumor activity mTOR PI3Ka kinase inhibition SAR mol docking; PI3Kα inhibitor; Pyrazole; Thienopyrimidine.

Three series of novel thienopyrimidine derivatives I [R1 = H, 4-F, 4-Br, 3,4-di-Cl; R2 = H, 4-Me, 4-Br, etc.], II and III [R3 = H, 4-F, 4-Br, 3,4-di-Cl; R4 = H, 4-Me, 4-Br, etc.] were synthesized and their IC50 values against four cancer cell lines HepG-2, A549, PC-3 and MCF-7 were evaluated. Most compounds showed moderate cytotoxicity against the tested cancer cell lines. The most promising compound I [R1 = R2 = H (IV)] showed moderate activity with IC50 values of 12.32 ± 0.96, 11.30 ± 1.19, 14.69 ± 1.32 and 9.80 ± 0.93μM, resp. The inhibitory activities of compounds IV and II [R1 = R2 = H (V)] against PI3Kα and mTOR kinase were further evaluated. Compound IV exhibited PI3Kα kinase inhibitory activity with IC50 of 9.47 ± 0.63μM. In addition, docking studies of compounds IV and V were also investigated.

Molecules published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Electric Literature of 18740-39-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Jirku, V’s team published research in Enzyme and Microbial Technology in 2000-06-30 | 4956-05-2

Enzyme and Microbial Technology published new progress about Bioadhesion. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, HPLC of Formula: 4956-05-2.

Jirku, V.; Masak, J.; Cejkova, A. published the artcile< Yeast cell attachment: a tool modulating wall composition and resistance to 5-bromo-6-azauracil>, HPLC of Formula: 4956-05-2, the main research area is yeast attachment cell wall polysaccharide bromoazauracil resistance.

The attachment of Candida utilis, Kluyveromyces lactis, and Saccharomyces cerevisiae cells stimulates an increase in the content of cell wall polysaccharides and mannoproteins, accompanied by increased resistance to the inhibitory effect of 5-bromo-6-azauracil. The covalent attachment of viable yeasts was accomplished (via dialdehyde-amino spacers) by reaction of aldehyde groups of the carrier with reactive amino groups in accessible cell surface proteins. The employed technique enables the optimization of yeast sources of β-1,3-, β-1,6- glucans, mannan, and mannoprotein. The modulatory effect of the cell attachment is discussed.

Enzyme and Microbial Technology published new progress about Bioadhesion. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, HPLC of Formula: 4956-05-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

von Angerer, S’s team published research in Science of Synthesis in 2004 | 99469-85-9

Science of Synthesis published new progress about Aromatization. 99469-85-9 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2S, Synthetic Route of 99469-85-9.

von Angerer, S. published the artcile< Product class 12: pyrimidines>, Synthetic Route of 99469-85-9, the main research area is review pyrimidine preparation cyclization ring transformation aromatization.

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification.

Science of Synthesis published new progress about Aromatization. 99469-85-9 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2S, Synthetic Route of 99469-85-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wu,Shao-Lan’s team published research in Scientia Sinica (English Edition) in 1957 | 15837-41-9

Scientia Sinica (English Edition) published new progress about Color reaction. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Application In Synthesis of 15837-41-9.

Chang, P.; Wu, Shao-Lan published the artcile< 5-Hydroxypyrimidines. I. Synthesis of 2-substituted 4,5,6-trihydroxypyrimidines>, Application In Synthesis of 15837-41-9, the main research area is .

Et benzyloxymalonate (I) condenses with various amidine derivatives to 2-substituted 5-benzyloxy-4,6-dihydroxypyrimidines (II, R, PhCH2O), converted to the corresponding 4,5,6-(HO)3 analogs (III, R, HO) by Pd-catalyzed hydrogenation; Raney Ni converts II (SH, PhCH2O) to II (H, PhCH2O) the PhCH2 group being unaffected. [In this abstract N:CR.N:C(OH).CR’:COH (II) and N:CR.N:C(OH).C(OH):COH (III) are designated by the Roman numeral, followed by R and R’, and by R, resp.] All III give pos. color reactions with FeCl3-NH4OH (blue-violet), Ba(OH)2 (violet-blue), and phosphomolybdic acid (deep blue), and decolorize (reduce) 2,6-dichlorophenolindophenol at various rates. PhCH2OCH2CO2H (IV) [20 g., b0.4 142-4°, prepared in 84% yield according to Fischer and Gohlke (C.A. 28, 1337) except that the mixture is acidified immediately with cooling instead of after removing the large excess of PhCH2OH], refluxed 2 hrs. with 25 ml. EtOH, 30 ml. C6H6, and 2 ml. concentrated H2SO4, the volatiles distilled, the residue neutralized with aqueous Na2CO3, extracted with Et2O, and the extract dried and distilled gives 74% PhCH2OCH2CO2Et (V), b8 135-7°, also prepared via PhCH2OCH2CN (VI); 50 ml. each of MeOH and 40% aqueous HCHO ice-cooled, stirred with 32.5 g. KCN until homogeneous, 57 g. PhCH2Cl in 100 ml. MeOH slowly stirred in at room temperature, the mixture heated 4 hrs. at 40°, cooled, poured into 100 ml. H2O, and the organic layer worked up give some PhCH2Cl, a small unidentified fraction, b. 110-25°, n25D 1.5073, d2020 1.081, and crude VI, b. 130-45°, redistilled to give 58-60% purified VI, b14 136-7°, which becomes progressively yellower on exposure to air, analyzes 1% low for N, and always leaves on redistillation a black residue shown to contain PhCH2OCONH2 [also prepared (m. 90.5-1.0°) by mixing 1 g. V with 5 ml. concentrated NH4OH and recrystallizing the product from hot H2O], and IV, b6 180°. Redistilled VI (74 g.) treated at 0° with 55 g. 95% EtOH previously saturated with HCl (33 g.), refluxed 4 hrs., yields 70% V, b5 125-6°, b10 138°, b12 145-6°; if the crude VI is only freed of more volatile materials and alcoholized undistd., 48% V (based on unrecovered PhCH2Cl) is obtained. No IV was obtained by dissolving 9.2 g. Na in 100 ml. hot PhCH2OH, adding 46.6 g. ClCH2CO2Na, and heating 5 hrs. at 160°, nor was VI identified among the products of reaction of 18 g. CuCN in 40 ml. anhydrous Et2O with 35 g. PhCH2OCH2Cl at 30°. Na (6.9 g.) in 90 ml. anhydrous EtOH treated with 68.7 g. (CO2Et)2 at room temperature, stirred 10 min., 58.2 g. V added dropwise, the mixture heated 4-5 hrs. at 50-60°, kept overnight at room temperature, acidified with glacial HOAc, poured into H2O, extracted with Et2O, the extracts dried, freed of Et2O, the residual liquid heated at 180-200°/15-20 mm. until evolution of CO ceases (2-3 hrs.), and the residue distilled gives 49% I, b0.4 127-9°, n20D 1.4900. I with concentrated NH4OH gives PhCH2OCH(CONH2)2, needles from H2O, m. 222°. Na (1.4 g.) in 30 ml. anhydrous EtOH treated with 16 g. I, then 8 g. EtBr, refluxed until neutral to litmus, cooled, poured into H2O, extracted with Et2O, and the extract dried and distilled gives 56% PhCH2OCEt(CO2Et)2 (VII), b0.4 133-4°, n20D 1.4862. Urea (3 g.) dissolved in a solution of 1.5 g. Na in 40 ml. anhydrous EtOH, 9 g. I added, the mixture refluxed 6 hrs. at 105-7°, cooled, the Na salt dissolved in a small amount of H2O, and the solution acidified with concentrated HCl precipitates 67% II (OH, PhCH2O), needles from H2O or 50% aqueous EtOH, decompose 202-3° after turning red at 180°. II (OH, PhCH2O) also gradually reddens on standing exposed to air, recrystallization of the red material from H2O yielding a colorless, air-stable, more H2O-soluble product (VIII), decompose 202-55°, believed to be II(OH, HO). VII condenses with NH2CONH2 in the presence of NaOEt to give 20% II(OH, Et), needles from EtOH, m 186-7°, stable in air. Similarly, 6.6 g. I, 3 g. NH2C(:NH)NH2.HNO3 (IX), and 1.2 g. Na in 30 ml. EtOH react (6 hrs.) to give 83% II(NH2, PhCH2O), needles from EtOH, m. 220-1° (decomposition); which also reddens in air, but is stabilized by recrystallization VII condenses with IX to 68% II(NH2, Et), recrystallized from EtOH, stable, m. 308-9° (decomposition). I condenses similarly with CH3C(:NH)NH2.HCl to give 54% II(Me, PhCH2O), needles from H2O, m. 263-4° (decomposition); with NH2CSNH2 to give 78% II(SH, PhCH2O), needles from EtOH, m. 140-1° (decomposition), reddens in air; and with NH2C(:NH)SEt.HBr to give 51% II(SEt, PhCH2O), needles from EtOH, m. 164-5° (decomposition), turning red-violet in air. II(SH, PhCH2O) (1 g.) in hot dilute NH4OH (2 ml. concentrated NH4OH cut with 16 ml. H2O) is heated 2 hrs. on steam with 3 g. Raney Ni, the mixture filtered hot, concentrated until crystals appear, and cooled gives 86% II(H, PhCH2O), m. 223-4° (decomposes) (from H2O). II(OH, PhCH2O) (1 g.) in 60 ml. HCO2H shaken with 0.1 g. PdO and H at room temperature and atm. pressure until 1 mol. equivalent H is taken up (20 min.) and the filtered mixture concentrated gives 98% dialuric acid (III, HO), m. 213-14° (decomposition) after reddening from 180°, readily air-oxidized. Similarly, II (NH2, PhCH2O) gives a quant. yield of III(NH2), which turns brown at 293-4° but remains solid up to 320°; this substance also turns red in air. Hydrogenation of II(Me, PhCH2O) in glacial HOAc gives 100% III(Me), stable in air, blackens at 290-1°, but is not molten at 320°. Similarly, II(H, PhCH2O) is reduced to III(H), air-stable, blackens at 284-5°, but does not m. at 320°.

Scientia Sinica (English Edition) published new progress about Color reaction. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Application In Synthesis of 15837-41-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ahadi, Somayeh’s team published research in Journal of the Iranian Chemical Society in 2013 | 2244-11-3

Journal of the Iranian Chemical Society published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Quality Control of 2244-11-3.

Ahadi, Somayeh; Abaszadeh, Maryam; Khavasi, Hamid Reza; Bazgir, Ayoob published the artcile< An efficient three-component synthesis of new amidinium salts>, Quality Control of 2244-11-3, the main research area is barbiturate amidinium salt preparation antibacterial; pyrimidine tetraone amidine acid diazabicycloundecene three component condensation.

A simple and efficient method for the synthesis of new amidinate salts containing barbiturate moiety (e.g., I) by a three-component condensation reaction of C-H acids, pyrimidine-tetraone and 1,8-diazabicycloundec-7-ene (DBU) in refluxing CHCl3 without any catalyst is reported.

Journal of the Iranian Chemical Society published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Quality Control of 2244-11-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Feng, Da’s team published research in Chinese Chemical Letters in 2021-12-31 | 18740-39-1

Chinese Chemical Letters published new progress about Anti-HIV agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, HPLC of Formula: 18740-39-1.

Feng, Da; Wei, Fenju; Sun, Yanying; Sharma, Prem Prakash; Zhang, Tao; Lin, Hao; Rathi, Brijesh; De Clercq, Erik; Pannecouque, Christophe; Kang, Dongwei; Zhan, Peng; Liu, Xinyong published the artcile< Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation>, HPLC of Formula: 18740-39-1, the main research area is boronic acid diarylpyrimidine preparation human immunodeficiency virus 1 inhibitor; acid boronic diarylpyrimidine preparation HIV1 nonnucleoside reverse transcriptase inhibitor; mol dynamics simulation boronic acid diarylpyrimidine HIV 1 inhibitor.

Drug resistance remains to be a serious problem with type I human immunodeficiency virus (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs). A series of novel boronic acid-containing diarylpyrimidine (DAPY) derivatives were designed via bioisosterism and scaffold-hopping strategies, taking advantage of the ability of a boronic acid group to form multiple hydrogen bonds. The target compounds were synthesized and evaluated for their anti-HIV activities and cytotoxicity in MT-4 cells. Compound 10j yielded the most potent activity and turned out to be a single-digit nanomolar inhibitor towards the HIV-1 IIIB [wild-type (WT) strain], L100I and K103N strains, with 50% effective concentration (EC50) values of 7.19-9.85 nmol/L. Moreover, 10j inhibited the double-mutant strain RES056 with an EC50 value of 77.9 nmol/L, which was 3.3-more potent than that of EFV (EC50 = 260 nmol/L) and comparable to that of ETR (EC50 = 32.2 nmol/L). 10J acted like classical NNRTIs with high affinity for WT HIV-1 reverse transcriptase (RT) with 50% inhibition concentration (IC50) value of 0.1837μmol/L. Furthermore, mol. dynamics simulation indicated that 10j was proposed as a promising mol. for fighting against HIV-1 infection through inhibiting RT activity. Overall, the results demonstrated that 10j could serve as a lead mol. for further modification to address virus-drug resistance.

Chinese Chemical Letters published new progress about Anti-HIV agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, HPLC of Formula: 18740-39-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Picazo, Edwige M H’s team published research in Journal of Heterocyclic Chemistry in 2021-04-30 | 5018-38-2

Journal of Heterocyclic Chemistry published new progress about Alkylation. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Electric Literature of 5018-38-2.

Picazo, Edwige M. H.; Heptinstall, Amy B.; Wilson, David M.; Cano, Celine; Golding, Bernard T.; Waring, Michael J. published the artcile< Cyclizations and fragmentations in the alkylation of 6-chloro-5-hydroxy-4-aminopyrimidines with aminoalkyl chlorides>, Electric Literature of 5018-38-2, the main research area is polysubstituted aminopyrimidine preparation; chlorohydroxyaminopyrimidine aminoalkyl chloride alkylation.

Substituted aminopyrimidines are an important class of compounds, in part because they frequently show biol. activity. Facile synthesis of polysubstituted aminopyrimidines is highly desirable for the synthesis of screening libraries. Authors describe a route to 4,6-diamino-5-alkoxypyrimidines via a SNAr-alkylation-SNAr sequence from readily available 4,6-dichloro-5-methoxypyrimidine, which allows the synthesis of such compounds with regiochem. control. The extension of this approach to alkylating agents bearing amino substituents led to unexpected and, in some cases, unprecedented products resulting from intramol. SNAr cyclization and subsequent fragmentation.

Journal of Heterocyclic Chemistry published new progress about Alkylation. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Electric Literature of 5018-38-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia