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Winkeler, Heinz Dieter’s team published research in Journal of Organic Chemistry in 1983-09-09 | 84955-32-8

Journal of Organic Chemistry published new progress about Nucleosides. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Application of C7H8N4O.

Winkeler, Heinz Dieter; Seela, Frank published the artcile< Synthesis of 2-amino-7-(2'-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, a new isostere of 2'-deoxyguanosine>, Application of C7H8N4O, the main research area is pyrrolopyrimidine deoxynucleoside; deoxyerythropentofuranosylpyrrolopyrimidinone.

The title compound (I) was prepared by treating 2-amino-4-methoxypyrrolo[2,3-d]pyrimidine with the sugar II, acidifying to deacylate, and demethylating with 4-MeC6H4SNa.

Journal of Organic Chemistry published new progress about Nucleosides. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Application of C7H8N4O.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mantymaki, Miia’s team published research in Chemistry of Materials in 2013-05-14 | 2244-11-3

Chemistry of Materials published new progress about Adhesive films. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Formula: C4H4N2O5.

Mantymaki, Miia; Hamalainen, Jani; Puukilainen, Esa; Sajavaara, Timo; Ritala, Mikko; Leskela, Markku published the artcile< Atomic layer deposition of LiF thin films from Lithd, Mg(thd)2, and TiF4 precursors>, Formula: C4H4N2O5, the main research area is atomic layer deposition lithium fluoride thin film precursor epitaxy; film adhesion.

Lithium fluoride is an interesting material because of its low refractive index and large band gap. Previously LiF thin films have been deposited mostly by phys. methods. In this study a new way of depositing thin films of LiF using at. layer deposition (ALD) is presented. Mg(thd)2(2,2,6,6-tetramethyl-3,5-heptanedionate) TiF4 and Lithd were used as precursors, and they produced crystalline LiF at a temperature range of 300-350 °C. The films were studied by UV-vis spectrometry, field emission SEM (FESEM), X-ray diffraction (XRD), at. force microscopy (AFM), time-of-flight elastic recoil detection anal. (ToF-ERDA), and energy dispersive X-ray spectroscopy (EDX). In addition, film adhesion was tested by a Scotch tape test. This method results in LiF films with a growth rate of approx. 1.4 Å per cycle. According to the ToF-ERDA measurements, the films are pure LiF with very small Mg and Ti impurities, the largest impurity being hydrogen with contents below 1 atom %.

Chemistry of Materials published new progress about Adhesive films. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Formula: C4H4N2O5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Park, Tae-Hong’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2011-02-07 | 89793-12-4

Chemical Communications (Cambridge, United Kingdom) published new progress about Adsorption (isotherm). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Safety of Ethyl 2-chloropyrimidine-5-carboxylate.

Park, Tae-Hong; Cychosz, Katie A.; Wong-Foy, Antek G.; Dailly, Anne; Matzger, Adam J. published the artcile< Gas and liquid phase adsorption in isostructural Cu3[biaryltricarboxylate]2 microporous coordination polymers>, Safety of Ethyl 2-chloropyrimidine-5-carboxylate, the main research area is gas liquid adsorption copper isostructural biaryltricarboxylate microporous polymer; crystal structure copper carboxypyrimidinyl carboxypyridinyl isophthalate microporous coordination polymer; copper biaryltricarboxylate microporous polymer preparation gas liquid adsorption.

N-Heteroarene substitution in biphenyl-based linkers enhances the uptake of electron-rich organosulfur mols. in microporous coordination polymers (MCP). Three isostructural MCPs are prepared (Cu3L2) possessing nearly uniform surface areas from homologous biaryl tricarboxylate linkers containing Ph (biphenyltricarboxylate UMCM-150), pyrimidine (carboxypyrimidinyl-isophthalate UMCM-150N2), and pyridine (carboxypyridinyl-isophthalate UMCM-150N1) units, building the ideal system to probe linker influence upon guest adsorption. The almost identical isotherms of H2 and CO2 in these MCPs imply that the N-heteroaryl linkers in the UMCM-150 analogs do not considerably affect the gas phase adsorption behavior. The electronic nature and contact interactions with the aromatic linker play an important role to enhance interactions between the host MCP framework and the large guest organic mols. in the liquid phase.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Okui, Kiyoshi’s team published research in Journal of Heterocyclic Chemistry in 1972 | 3286-55-3

Journal of Heterocyclic Chemistry published new progress about 3286-55-3. 3286-55-3 belongs to class pyrimidines, and the molecular formula is C5H6ClN3O, Related Products of 3286-55-3.

Okui, Kiyoshi; Ito, Kiyohiko; Koizumi, Masuo; Fukumoto, Keiichiro; Kametani, Tetsuji published the artcile< Syntheses of heterocyclic compounds. CDXCI. Pyrimidine derivatives. V. Abnormal condensation products of 4-amino-6-chloro-2-methoxypyrimidine with p-nitrobenzenesulfonyl chloride>, Related Products of 3286-55-3, the main research area is pyridinium pyrimidine betaines.

Condensation of 4-amino-6-chloro-2-methoxypyrimidine with p-O2NC6H4SO2Cl gave, in addition to 6-chloro-2-methoxy-4-(p-nitrobenzenesulfonamido)pyrimidine (I), two abnormal by-products, 1-[2-methoxy-4-(p-nitrobenzenesulfonamido)pyrimidin-6-yl]pyridinium N,N-betaine (II) and N-(p-nitrobenzenesulfonyl)-β-ureido-β-pyridinium arcylamide N,N-betaine (III).

Journal of Heterocyclic Chemistry published new progress about 3286-55-3. 3286-55-3 belongs to class pyrimidines, and the molecular formula is C5H6ClN3O, Related Products of 3286-55-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Schomaker, Jennifer M’s team published research in Journal of Organic Chemistry in 2001-10-19 | 3921-01-5

Journal of Organic Chemistry published new progress about Arylation. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, COA of Formula: C4H2Br2N2.

Schomaker, Jennifer M.; Delia, Thomas J. published the artcile< Arylation of Halogenated Pyrimidines via a Suzuki Coupling Reaction>, COA of Formula: C4H2Br2N2, the main research area is Suzuki coupling arylation halopyrimidine; pyrimidine aryl preparation.

The Suzuki coupling reaction was used extensively for the synthesis of a wide variety of unsym. biaryl compounds The authors have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines.

Journal of Organic Chemistry published new progress about Arylation. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, COA of Formula: C4H2Br2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Johns, Stephen C’s team published research in Tetrahedron Letters in 2014-05-28 | 2244-11-3

Tetrahedron Letters published new progress about Acridines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Recommanded Product: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.

Johns, Stephen C.; Crouch, Laurie L. E.; Grieve, Stephen; Maloney, Holly L.; Peczkowski, Gary R.; Jones, Allison E.; Sharp, Duncan; Smith, Robert B. published the artcile< A rapid, chromatography-free route to substituted acridine-isoalloxazine conjugates under microwave irradiation>, Recommanded Product: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, the main research area is acridine isoalloxazine conjugate preparation condensation microwave irradiation.

Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine-isoalloxazine conjugates. The combination of these two moieties, both of biol. interest, was achieved by a chromatog.-free route.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Amano, Yohei’s team published research in Chemical & Pharmaceutical Bulletin in 2014-03-31 | 89793-12-4

Chemical & Pharmaceutical Bulletin published new progress about Aromatic amines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Safety of Ethyl 2-chloropyrimidine-5-carboxylate.

Amano, Yohei; Noguchi, Masayuki; Shudo, Koichi published the artcile< Diarylamines incorporating hexahydrophenalene or octahydrobenzoheptalene as retinoid X receptor (RXR)-specific agonists>, Safety of Ethyl 2-chloropyrimidine-5-carboxylate, the main research area is arylamino hexahydro phenalene preparation retinoid X receptor agonist; octahydro benzoheptalene arylamino preparation retinoid X receptor agonist.

A series of diarylamines I (X = CH2, R1 = H, Me; X = CH2CH2, R1 = H; Z = CH, N; R2 = H, Me, Et, cyclopropylmethyl, i-Bu, PhCH2) incorporating hexahydrophenalene or octahydrobenzoheptalene as a hydrophobic moiety was synthesized and examined for their activities towards retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Most of these compounds showed agonistic activity towards RXRs, but were inactive towards RARs. These RXR-specific ligands showed synergistic activity in RARα,β ligand-induced terminal differentiation of leukemia cell line HL-60.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Liu, Zhiqing’s team published research in ACS Medicinal Chemistry Letters in 2014-04-10 | 18740-39-1

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Formula: C6H2Cl2N2S.

Liu, Zhiqing; Ai, Jing; Peng, Xia; Song, Zilan; Wu, Kui; Zhang, Jing; Yao, Qizheng; Chen, Yi; Ji, Yinchun; Yang, Yanhong; Geng, Meiyu; Zhang, Ao published the artcile< Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities>, Formula: C6H2Cl2N2S, the main research area is arylaminopyrimidine preparation SAR cMet ALK multikinase inhibitor antitumor; 2,4-diarylaminopyrimidine analogues; C1-Substituted-N3-benzazepine; c-Met/ALK dual inhibitor; structure repurposing.

By repurposing a typical dopamine D1/D5 receptor agonist motif, C1-substituted-N3-benzazepine or benzazecine, into the classical RTK inhibitor 2,4-diaminopyrimidine skeleton, a series of new 2,4-diarylaminopyrimidine analogs (DAAPalogues) were developed. Two compounds were identified possessing high potency against both c-Met and ALK kinases. Compound (I) displayed appreciable antitumor efficacy at the dose of 1 mg/kg in the ALK-driven BF3/EML4-ALK xenograft mice model.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Formula: C6H2Cl2N2S.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Krasavin, Mikhail’s team published research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016 | 6554-61-6

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antimalarials. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, COA of Formula: C4H2Cl2N2.

Krasavin, Mikhail; Mujumdar, Prashant; Parchinsky, Vladislav; Vinogradova, Tatiana; Manicheva, Olga; Dogonadze, Marine published the artcile< Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads>, COA of Formula: C4H2Cl2N2, the main research area is quinolinylimidazoline derivative preparation antitubercular antimalarial; 2-imidazoline; Antimalarial; Buchwald–Hartwig; antitubercular; microwave chemistry; non-cytotoxic; quinoline.

A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald-Hartwig-type imidazoline arylation chem. developed earlier. Compounds were tested for biol. activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hornillo-Araujo, Ana R’s team published research in Organic & Biomolecular Chemistry in 2006-05-07 | 84955-32-8

Organic & Biomolecular Chemistry published new progress about Crystal structure. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Formula: C7H8N4O.

Hornillo-Araujo, Ana R.; Burrell, Adam J. M.; Aiertza, Miren K.; Shibata, Takayuki; Hammond, David M.; Edmont, Dolores; Adams, Harry; Margison, Geoffrey P.; Williams, David M. published the artcile< The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine>, Formula: C7H8N4O, the main research area is tricyclic pyrrolopyrimidine analog thioguanine methylguanine preparation; thiopyran tricyclic pyrrolopyrimidine analog thioguanine methylguanine preparation; thiepane tricyclic pyrrolopyrimidine analog thioguanine methylguanine preparation; DNA cross linking tricyclic pyrrolopyrimidine analog thioguanine methylguanine preparation; oligonucleotide pseudosubstrate DNA linking tricyclic pyrrolopyrimidine analog thioguanine methylguanine.

The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogs of S6-methylthioguanine are described. The crystal structures and pKa values of these and related O6-methylguanine analogs are reported. All compounds display higher pKa values than O6-methylguanine with the sulfur-containing analogs being the more basic and exhibiting higher stability in aqueous solution In a standard substrate assay with the human repair protein O6-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analog displayed activity.

Organic & Biomolecular Chemistry published new progress about Crystal structure. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Formula: C7H8N4O.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia