Day: October 19, 2022

Application of 29458-38-6On October 31, 1978 ,《O-Methylation of barbituric acids》 appeared in Farmaco, Edizione Scientifica. The author of the article were Stankiewicz, K.; Bobranski, B.. The article conveys some information:

Treating barbituric and N-phenylbarbituric acid with dry HCl in MeOH at room temperature gave 77.4% I (R = H) and 85% I (R = Ph), resp. In the part of experimental materials, we found many familiar compounds, such as 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Application of 29458-38-6)

6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 29458-38-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C13H12N2O4On November 12, 2009 ,《Coordination Chemistry Based Approach to Lipophilic Inhibitors of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase》 appeared in Journal of Medicinal Chemistry. The author of the article were Deng, Lisheng; Sundriyal, Sandeep; Rubio, Valentina; Shi, Zheng-zheng; Song, Yongcheng. The article conveys some information:

1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) in the non-mevalonate pathway found in most bacteria is a validated anti-infective drug target. Fosmidomycin, a potent DXR inhibitor, is active against Gram-neg. bacteria. A coordination chem. and structure based approach was used to discover a novel, lipophilic DXR inhibitor with an IC50 of 1.4 μM. It exhibited a broad spectrum of activity against Gram-neg. and -pos. bacteria with minimal inhibition concentrations of 20-100 μM (or 3.7-19 μg/mL). In the part of experimental materials, we found many familiar compounds, such as Methyl 2-benzyl-5,6-dihydroxypyrimidine-4-carboxylate(cas: 519032-07-6COA of Formula: C13H12N2O4)

Methyl 2-benzyl-5,6-dihydroxypyrimidine-4-carboxylate(cas: 519032-07-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. COA of Formula: C13H12N2O4They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 3-(Pyrimidin-5-yl)benzaldehydeOn March 10, 2016, Wu, Yong-Jin; Guernon, Jason; Yang, Fukang; Snyder, Lawrence; Shi, Jianliang; McClure, Andrea; Rajamani, Ramkumar; Park, Hyunsoo; Ng, Alicia; Lewis, Hal; Chang, Chieh Ying; Camac, Dan; Toyn, Jeremy H.; Ahlijanian, Michael K.; Albright, Charles F.; Macor, John E.; Thompson, Lorin A. published an article in ACS Medicinal Chemistry Letters. The article was 《Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents》. The article mentions the following:

By targeting the flap backbone of the BACE1 active site, the authors discovered 6-dimethylisoxazole-substituted biaryl aminothiazine I with 34-fold improved BACE1 inhibitory activity over the lead compound The cocrystal structure of I bound to the active site indicated two hydrogen-bond interactions between the dimethylisoxazole and threonine 72 and glutamine 73 of the flap. Incorporation of the dimethylisoxazole substitution onto the related aminothiazine carboxamide series led to pyrazine-carboxamide II as a very potent BACE1 inhibitor (IC50 < 1 nM). This compound demonstrated robust brain Aβ reduction in rat dose-response studies. Thus, compound II may be useful in testing the amyloid hypothesis of Alzheimer's disease. The experimental process involved the reaction of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Quality Control of 3-(Pyrimidin-5-yl)benzaldehyde)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Quality Control of 3-(Pyrimidin-5-yl)benzaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wang, Yujie; Rong, Jie; Zhang, Bin; Hu, Liming; Wang, Xiaoli; Zeng, Chengchu published an article on February 15 ,2015. The article was titled 《Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry.Application In Synthesis of Methyl 2-benzyl-5,6-dihydroxypyrimidine-4-carboxylate The information in the text is summarized as follows:

A series of novel β-diketo derivatives which combined the virtues of dihydroxypyrimidine carboxamide derived from the evolution of diketo acids and polyhydroxylated aromatics moieties were designed and synthesized as potential HIV-1 integrase (IN) inhibitors and their inhibition to the strand transfer process of HIV-1 integrase and anti-HIV-1 activity evaluated. The result indicates that 3,4,5-trihydroxylated aromatic derivatives exhibit good inhibition to HIV-1 integrase, but dihydroxylated aromatic derivatives show little inhibition to HIV-1 integrase. In addition, the preliminary structure-activity relationship (SAR) of these new derivatives was rationalized by docking studies.Methyl 2-benzyl-5,6-dihydroxypyrimidine-4-carboxylate(cas: 519032-07-6Application In Synthesis of Methyl 2-benzyl-5,6-dihydroxypyrimidine-4-carboxylate) was used in this study.

Methyl 2-benzyl-5,6-dihydroxypyrimidine-4-carboxylate(cas: 519032-07-6) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Application In Synthesis of Methyl 2-benzyl-5,6-dihydroxypyrimidine-4-carboxylate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Useful preparations involving the reactions of nucleophiles with trimethylammonio derivatives of nitrogen heterocycles》 were Barlin, G. B.; Young, A. C.. And the article was published in Journal of the Chemical Society in 1972. Quality Control of 2-Methoxy-5-nitropyrimidine The author mentioned the following in the article:

Alkoxy, amino, propylamino, hydrazino, mercapto, fluoro, and cyano derivatives of pyridine, pyrimidine, quinoline, quinazoline, and purine were prepared by treatment of the corresponding trimethylammonio compound with the appropriate nucleophile; thus, 71% 4-(propyl-amino)pyrimidine was prepared from trimethyl-4-pyrimidinyl-ammonium salt and PrNH2. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxy-5-nitropyrimidine(cas: 14001-69-5Quality Control of 2-Methoxy-5-nitropyrimidine)

2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2-Methoxy-5-nitropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Cheng, Hengmiao; Nair, Sajiv K.; Murray, Brion W.; Almaden, Chau; Bailey, Simon; Baxi, Sangita; Behenna, Doug; Cho-Schultz, Sujin; Dalvie, Deepak; Dinh, Dac M.; Edwards, Martin P.; Feng, Jun Li; Ferre, Rose Ann; Gajiwala, Ketan S.; Hemkens, Michelle D.; Jackson-Fisher, Amy; Jalaie, Mehran; Johnson, Ted O.; Kania, Robert S.; Kephart, Susan; Lafontaine, Jennifer; Lunney, Beth; Liu, Kevin K.-C.; Liu, Zhengyu; Matthews, Jean; Nagata, Asako; Niessen, Sherry; Ornelas, Martha A.; Orr, Suvi T. M.; Pairish, Mason; Planken, Simon; Ren, Shijian; Richter, Daniel; Ryan, Kevin; Sach, Neal; Shen, Hong; Smeal, Tod; Solowiej, Jim; Sutton, Scott; Tran, Khanh; Tseng, Elaine; Vernier, William; Walls, Marlena; Wang, Shuiwang; Weinrich, Scott L.; Xin, Shuibo; Xu, Haiwei; Yin, Min-Jean; Zientek, Michael; Zhou, Ru; Kath, John C. published 《Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants》.Journal of Medicinal Chemistry published the findings.HPLC of Formula: 90213-66-4 The information in the text is summarized as follows:

First generation EGFR TKIs (gefitinib, erlotinib) provide significant clin. benefit for NSCLC cancer patients with oncogenic EGFR mutations. Ultimately, these patients’ disease progresses, often driven by a second-site mutation in the EGFR kinase domain (T790M). Another liability of the first generation drugs is severe adverse events driven by inhibition of WT EGFR. As such, our goal was to develop a highly potent irreversible inhibitor with the largest selectivity ratio between the drug-resistant double mutants (L858R/T790M, Del/T790M) and WT EGFR. A unique approach to develop covalent inhibitors, optimization of reversible binding affinity, served as a cornerstone of this effort. PF-06459988 was discovered as a novel, third generation irreversible inhibitor, which demonstrates (i) high potency and specificity to the T790M-containing double mutant EGFRs, (ii) minimal intrinsic chem. reactivity of the electrophilic warhead, (iii) greatly reduced proteome reactivity relative to earlier irreversible EGFR inhibitors, and (iv) minimal activity against WT EGFR. After reading the article, we found that the author used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4HPLC of Formula: 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. HPLC of Formula: 90213-66-4They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,El-Kalyoubi, Samar A. published 《Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent》.Chemistry Central Journal published the findings.Related Products of 3764-01-0 The information in the text is summarized as follows:

A series of pyrimido[5,4-e][1,2,4]triazines I (R1 = Ph, 4-ClC6H4, 4-BrC6H4, 4-HOC6H4, 4-O2NC6H4) was obtained via condensation of 6-hydrazinyluracil with various benzaldehydes to give the hydrazones II (R2 = H) followed by nitrosation with HNO2 and intramol. cyclization. On the other hand, pyrazolopyrimidine III (R3 = 1-phenylvinyl) was obtained by the reaction of hydrazone II (R1 = Ph; R2 = Me) with DMF-DMA via formation of the intermediate IV whereas the compound III (R3 = Me) was prepared by refluxing hydrazinyluracil with DMF-DMA in DMF directly. The newly synthesized compounds I, II, III and IV were evaluated in-vitro for their anticancer activity against human lung carcinoma (A549). The compound I (R1 = 4-ClC6H4) showed the highest effect with IC50 value 3.6 μM, followed by compounds III (R3 = 1-phenylvinyl), II (R1 = R2 = H), IV, II (R1 = 4-O2NC6H4; R2 = H) and I (R1 = 4-O2NC6H4). After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Related Products of 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Related Products of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Liu, Ju; Wu, Shuang; Wang, Huan; Du, Si-Yuan; Li, Zhen; Shen, Ji-Wei; Chen, Ye; Ding, Shi published an article in 2022. The article was titled 《Novel 2,4-diarylaminopyrimidine derivatives containing pyridine moiety: design, synthesis, crystal structure and biological evaluation》, and you may find the article in Chinese Journal of Structural Chemistry.Electric Literature of C4H2Cl2N2 The information in the text is summarized as follows:

A series of 2,4-diarylaminopyrimidine derivatives I [R = H, 4-Me, 4-F, etc.] containing pyridine structure were designed and synthesized. The crystal structures of compounds I [R = 3-Cl, 4-F-3-Cl] were obtained from X-ray diffraction. The crystal structure of I [R = 3-Cl] (C25H20ClFN6O2) belongs to the monoclinic system, space group P21/c with a = 11.0500(10), b = 18.3045(17), c = 13.5646(9) Å and β = 122.806(5)°. I [R = 4-F-3-Cl] (C25H19ClF2N6O2) was of monoclinic system, space group P21/c with a = 10.9998(18), b = 18.517(3), c = 13.6355(16) Å and β = 123.315(9)°. The bioassay results showed all of the target compounds I exhibited potential antiproliferative activities against MKN-45, HT-29, A549, K562 and GIST882 cell lines. Among them, compounds I [R = H, 4-Cl, 4-F-3-Cl] exhibited remarkable inhibitory activities against GIST882, K562 and A549 cell lines with IC50 values of 0.68, 0.38 and 0.60μM, resp., which were comparable to that of the pos. control foretinib. The results came from multiple reactions, including the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Electric Literature of C4H2Cl2N2)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Electric Literature of C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Singh, Vishal K.; Chaurasia, Himani; Mishra, Richa; Srivastava, Ritika; Naaz, Farha; Kumar, Pradeep; Singh, Ramendra K. published an article in Journal of Molecular Structure. The title of the article was 《Docking, ADMET prediction, DFT analysis, synthesis, cytotoxicity, antibacterial screening and QSAR analysis of diarylpyrimidine derivatives》.Synthetic Route of C4H2Cl2N2 The author mentioned the following in the article:

A new series of 2, 4 disubstituted diarylpyrimidine derivatives has been designed, synthesized and screened for their antibacterial activity. QSAR studies followed by antibacterial screening using broth dilution technique showed excellent MIC values against four human pathogens, namely Escherichia coli, Pseudomonas aeruginosa, Bacillus cerus and Staphylococcus aureus. Some mols. were found to be highly active (MIC value up to 3.1 μg/mL) against different types of human pathogens, like P. aeruginosa, E. coli, S. aureus and B. cerus. All compounds having MIC values greater than reference drugs were subjected for combinatorial antibacterial screening with chloramphenicol, cycloheximide and paromomycin as standard references and fractional inhibitory concentration (FIC) values of compounds exhibited great synergistic effect as their MIC values were lowered by 1/33, 1/16 and 1/8 of the original MIC′s. In vitro evaluation of cytotoxicity indicates that these mols. were less toxic against HEK293 (Human embryonic kidney) cell lines. Mol. docking assessment also revealed that all designed 2,4 disubstituted diarylpyrimidine derivatives showed good interaction within active site of PDF enzyme (PDB ID: 1G2A). 2, 4 disubstituted diarylpyrimidines formed H-bond with amino acid residue Leu91, Arg97, Ile44, Ile94, Gly89 and Glu95 at a distance of 2.78 – 3.20 Å. Mols. also showed π – + and π – π interaction with amino acid residues Arg97 and His132. In silico assessment of all mols. exhibited more than 88% of intestinal absorption, which was higher than the reference antibiotics viz. chloramphenicol (69.94%), cycloheximide (74.26%) and paromomycin (76.46%). In the experiment, the researchers used many compounds, for example, 2,4-Dichloropyrimidine(cas: 3934-20-1Synthetic Route of C4H2Cl2N2)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Synthetic Route of C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Ayala, Caitlan E.; Perez, Rocio L.; Mathaga, John K.; Watson, Aanesa; Evans, Tristan; Warner, Isiah M. published an article in ACS Applied Polymer Materials. The title of the article was 《Fluorescent Ionic Probe for Determination of Mechanical Properties of Healed Poly(ethylene-co-methacrylic acid) Ionomer Films》.Product Details of 1193-21-1 The author mentioned the following in the article:

In recent years, advanced materials with properties resembling biol. systems, particularly artificial muscles, have received intense scrutiny. This is because the interesting conformational shape characteristics of such materials have benefited a variety of technologies, including textiles, 3D printing, and medical devices. Although a multitude of shape memory properties have been studied and developed in recent years, self-healing of these polymers after puncture or rupture has also become a major area of study. Most techniques for detection of such processes are mech. based and require considerable hands-on monitoring. Thus, a rapid visual detection method for self-healing is highly desirable. Herein, we describe fluorescence studies for rapid detection of self-healing properties of a partially neutralized sodium ionomer poly(ethylene-co-methacrylic acid) (PEMA). In this study, two different fluorophores, parent non-ionic 4,6-dipyrenylpyrimidine and ionic 4,6-dipyrenylpyrimidinium iodide fluorophores, were evaluated as possible sensors of self-healing. Incorporation of these probes via solution blending and compatibility into a PEMA of these fluorophores were evaluated. Thermal characterizations using differential scanning calorimetry were also performed to elucidate phys. characteristics of healed sites. Ratiometric fluorescence emission variations were explored within puncture-healed ionomer films and related to Young’s modulus properties with good linearity, indicating potential utility of this approach for monitoring elastic modulus properties after healing has occurred. Further statistical analyses of mech. processes using quadratic discriminant anal. resulted in development of several highly accurate predictive models for determining time since damage healing. In the experiment, the researchers used many compounds, for example, 4,6-Dichloropyrimidine(cas: 1193-21-1Product Details of 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia