Day: October 21, 2022

Application In Synthesis of 4,6-DichloropyrimidineIn 2019 ,《Carbazole- and triphenylamine-substituted pyrimidines: synthesis and photophysical properties》 was published in Molecules. The article was written by Achelle, Sylvain; Rodriguez-Lopez, Julian; Larbani, Massinissa; Plaza-Pedroche, Rodrigo; Robin-le Guen, Francoise. The article contains the following contents:

A series of pyrimidine derivatives bearing one, two or three triphenylamine/9-ethylcarbazole substituents has been synthesized by Suzuki cross-coupling reaction. All compounds showed absorption bands in the UV region and the emission of violet-blue light upon irradiation Protonation led to quenching of the fluorescence, although some derivatives remained luminescent with the appearance of a new red-shifted band in the spectra. Accurate control of the amount of acid enabled white photoluminescence to be obtained both in solution and in solid state. In addition to this study using 4,6-Dichloropyrimidine, there are many other studies that have used 4,6-Dichloropyrimidine(cas: 1193-21-1Application In Synthesis of 4,6-Dichloropyrimidine) was used in this study.

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Computed Properties of C6H6BrClN2On March 31, 1984, Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi published an article in Synthesis. The article was 《Studies on pyrimidine derivatives; XXXV. Iodination of 2-aminopyrimidines, 4-aminopyrimidines, and 4-pyrimidinones with iodine chloride in situ》. The article mentions the following:

Iodination of pyrimidines I (R = H, Me, Me2CH, Ph; R1 = NH2; R2 = H; R3 = Me) with ICl generated in situ in AcOH gave 42-55% I (R, R1, R3 = same as above; R2 = I). Similarly, II (R, R2, R3 same as above) gave 51-72% II (R2 = I), which was chlorinated with POCl3 to give I (R, R3 = same, R1 = Cl, R2 = I), which was dechlorinated with p-MeC6H4SO2NHNH2 and Na2CO3 to give 77-87% I (R, R3 = same, R1 = H, R2 = I).5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1Computed Properties of C6H6BrClN2) was used in this study.

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C6H6BrClN2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Crich, David; Yao, Qingwei published an article on January 15 ,1998. The article was titled 《Free radical chemistry of nucleosides and nucleotides Ring opening of C4′-radicals》, and you may find the article in Tetrahedron.Related Products of 122567-97-9 The information in the text is summarized as follows:

It is demonstrated that nucleotide C4′ radicals may be generated from a C4′-thioester on treatment with tributyltin hydride. When the reaction is conducted in benzene at reflux the C4′ radical expels the C3′-phosphate group to give a radical cation. This species undergoes deprotonation to an allylic radical which suffers cleavage of the deoxyribose ring. Similar reactions are observed when the reaction is conducted with tris(trimethylsilyl)silane in place of the stannane. In methanolic benzene the radical cation is trapped by methanol to give a new C4′ radical which is quenched before ring opening. The behavior of C4′ radicals toward ring opening is discussed in terms of the conformations imposed by the substituents at C3′. In the experimental materials used by the author, we found ((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9Related Products of 122567-97-9)

((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 122567-97-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Photochemistry of aromatic compounds. VII. Influence of aliphatic amines on the photochemistry of 5-bromopyrimidines in methanol》 were Nasielski, J.; Kirsch-Demesmaeker, A.; Nasielski-Hinkens, R.. And the article was published in Tetrahedron in 1972. Electric Literature of C6H8N2O The author mentioned the following in the article:

Uv irradiation of 2-methoxy-, 2-phenyl- and 2-dimethylamino-5-bromopyrimidine in MeOH yields the corresponding dehalogenated, methylated and hydroxymethylated compounds Added Et2NH or Et3N strongly increases the rate of dehalogenation. Amines influence the photochemistry of these compounds by transfering an electron to the excited state of the bromopyrimidines. In addition to this study using 2-Methoxy-4-methylpyrimidine, there are many other studies that have used 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Electric Literature of C6H8N2O) was used in this study.

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Electric Literature of C6H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Manohar, Sunny; Satya Pavan, V.; Taylor, Dale; Kumar, Deepak; Ponnan, Prija; Wiesner, Lubbe; Rawat, Diwan S. published 《Highly active 4-aminoquinoline-pyrimidine based molecular hybrids as potential next generation antimalarial agents》.RSC Advances published the findings.Formula: C4HCl3N2 The information in the text is summarized as follows:

In order to overcome the problem of emerging drug resistance in malarial chemotherapy, a series of highly active 4-aminoquinoline-pyrimidine hybrids were synthesized and evaluated for their antimalarial activity against CQ-sensitive (NF54) and CQ-resistant (Dd2) strains of P. falciparum in an in vitro assay. The most active hybrid 19f exhibited 74-fold better potency than chloroquine and 4-fold better potency than artesunate against the drug-resistant strain of P. falciparum. Compound 19e, when evaluated for in vivo activity in the P. berghei-mouse malaria model showed 93.9% parasite suppression at 30 mg kg-1 dose on Day 4 with a mean survival time of 11 days. To gain insights towards the mechanism of action of these hybrids, heme binding and mol. modeling studies were performed on the most active hybrids. It was observed that inhibition of formation of β-hematin and dihydrofolate reductase-thymidylate synthase Pf-DHFR-TS enzyme could be associated with the observed antimalarial activity of these compounds After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Formula: C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Zhang, Xiao; Lu, Guo-ping; Cai, Chun published 《Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: an electrophile-nucleophile dual activation by [Omim]Br for the reaction》.Green Chemistry published the findings.Recommanded Product: 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

A facile aromatic nucleophilic substitution (SNAr) reaction in recyclable [Omim]Br under relatively mild conditions has been described. An electrophile-nucleophile dual activation by [Omim]Br is also discovered based on control experiments, 1H NMR and IR spectroscopies. This chem. provides an efficient and metal-free approach for the generation of Caryl-X (X=S, N, O) bonds, many of which are significant synthetic intermediates or drugs, making this methodol. attractive to both synthetic and medicinal chem.2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 2,4,6-Trichloropyrimidine) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Recommanded Product: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2019,CrystEngComm included an article by Hyodo, Tadashi; Kawahata, Masatoshi; Hikami, Yuya; Komatsu, Ai; Tominaga, Masahide; Yamaguchi, Kentaro. Reference of 4,6-Dichloropyrimidine. The article was titled 《Cycloalkanes and cycloalkenes in dispersive force oriented inclusion crystals by a functionalized acyclic host molecule》. The information in the text is summarized as follows:

A disubstituted adamantane derivative bearing chloropyrimidine units (1) was synthesized as an acyclic host mol. to construct guest-inclusion crystalline materials, and the mol. structures of these crystalline materials were determined by X-ray crystallog. anal. The crystallization of 1 and trans-decahydronaphthalene (a) in chloroform afforded co-crystal (1a) with 2 : 1 host : guest complexation stoichiometry. The guest mol. was accommodated within the cavity of the cyclic dimers of 1 built from Cl···π interactions between the chloropyrimidine units. These complexes were assembled into network structures through intermol. interactions. From the Hirshfeld surface anal. and the 2D fingerprint plot of a in co-crystal 1a, the maximum contribution is from the H···H contacts between 1 and a, indicating that the main driving force for the guest inclusion is dispersive force. Co-crystals containing cycloalkanes and cycloalkenes (b-f) and having the same stoichiometry were obtained under identical conditions. In all the co-crystals, the shapes and sizes of the cyclic dimers and the mol. networks were similar to those of crystal 1a, and the mol. structures of the guests were characterized. In addition to this study using 4,6-Dichloropyrimidine, there are many other studies that have used 4,6-Dichloropyrimidine(cas: 1193-21-1Reference of 4,6-Dichloropyrimidine) was used in this study.

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Reference of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Small Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies》 were Lim, Andrew S. T.; Vincent, Isabel M.; Barrett, Michael P.; Gilbert, Ian H.. And the article was published in ACS Omega in 2019. Product Details of 3764-01-0 The author mentioned the following in the article:

The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chem. scaffolds and modes of action. It is also vital to design compounds with optimal physicochem. properties to permeate the bacterial cell envelope. We described an approach of combining and integrating whole cell screening and metabolomics into early antibacterial drug discovery using a library of small polar compounds Whole cell screening of a diverse library of small polar compounds against Staphylococcus aureus gave compound I. Hit expansion was carried out to determine structure-activity relationships. A selection of compounds from this series, together with other screened active compounds, was subjected to an initial metabolomics study to provide a metabolic fingerprint of the mode of action. I and its analogs have a different mode of action from some of the known antibacterial compounds tested. This early study highlighted the potential of whole cell screening using a and metabolomics in early antibacterial drug discovery, and future works will include improving potency and performing orthogonal studies to confirm the modes of action.2,4,6-Trichloropyrimidine(cas: 3764-01-0Product Details of 3764-01-0) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《N-Nitroheterocycles: Bench-Stable Organic Reagents for Catalytic Ipso-Nitration of Aryl- and Heteroarylboronic Acids》 was written by Zhang, Kun; Budinska, Alena; Passera, Alessandro; Katayev, Dmitry. Formula: C5H5N3O3 And the article was included in Organic Letters on April 3 ,2020. The article conveys some information:

Photocatalytic and metal-free protocols to access various aromatic and heteroaromatic nitro compounds through ipso-nitration of readily available boronic acid derivatives were developed using non-metal-based, bench-stable, and recyclable nitrating reagents. These methods are operationally simple, mild, regioselective and possess excellent functional group compatibility, delivering desired products in up to 99% yield. In addition to this study using 2-Methoxy-5-nitropyrimidine, there are many other studies that have used 2-Methoxy-5-nitropyrimidine(cas: 14001-69-5Formula: C5H5N3O3) was used in this study.

2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Formula: C5H5N3O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Visible Light-Promoted Aliphatic C-H Arylation Using Selectfluor as a Hydrogen Atom Transfer Reagent》 was written by Zhao, Hong; Jin, Jian. Synthetic Route of C6H8N2O And the article was included in Organic Letters on August 16 ,2019. The article conveys some information:

A mild, practical method for direct arylation of unactivated C(sp3)-H bonds with heteroarenes has been achieved via photochem. Selectfluor is used as a hydrogen atom transfer reagent under visible light irradiation A diverse range of chem. feedstocks, such as alkanes, ketones, esters, and ethers, and complex mols. readily undergo intermol. C(sp3)-C(sp2) bond formation. Moreover, a broad array of heteroarenes, including pharmaceutically useful scaffolds, can be alkylated effectively by the protocol presented here. The experimental process involved the reaction of 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Synthetic Route of C6H8N2O)

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Synthetic Route of C6H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia