Day: October 21, 2022

Baiazitov, Ramil; Du, Wu; Lee, Chang-Sun; Hwang, Seongwoo; Almstead, Neil G.; Moon, Young-Choon published an article in Synthesis. The title of the article was 《Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines》.HPLC of Formula: 86443-51-8 The author mentioned the following in the article:

Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. The experimental process involved the reaction of 2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8HPLC of Formula: 86443-51-8)

2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 86443-51-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Demina, Galina R.; Makarov, Vadim A.; Nikitushkin, Vadim D.; Ryabova, Olga B.; Vostroknutova, Galina N.; Salina, Elena G.; Shleeva, Margarita O.; Goncharenko, Anna V.; Kaprelyants, Arseny S. published their research in PLoS One on December 31 ,2009. The article was titled 《Finding of the low molecular weight inhibitors of resuscitation promoting factor enzymatic and resuscitation activity》.SDS of cas: 52854-14-5 The article contains the following contents:

Background: Resuscitation promoting factors (RPF) are secreted proteins involved in reactivation of dormant actinobacteria, including Mycobacterium tuberculosis. They have been considered as prospective targets for the development of new anti-tuberculosis drugs preventing reactivation of dormant tubercle bacilli, generally associated with latent tuberculosis. However, no inhibitors of Rpf activity have been reported so far. The goal of this study was to find low mol. weight compounds inhibiting the enzymic and biol. activities of Rpfs. Methodol./Principal Findings: Here the authors describe a novel class of 2-nitrophenylthiocyanates (NPT) compounds that inhibit muralytic activity of Rpfs with IC50 1-7 μg/mL. Fluorescence studies revealed interaction of active NPTs with the internal regions of the Rpf mol. Candidate inhibitors of Rpf enzymic activity showed a bacteriostatic effect on growth of Micrococcus luteus (in which Rpf is essential for growth protein) at concentrations close to IC50. The candidate compounds suppressed resuscitation of dormant (“”non-culturable””) cells of M. smegmatis at 1 μg/mL or delayed resuscitation of dormant M. tuberculosis obtained in laboratory conditions at 10 μg/mL. However, they did not inhibit growth of active mycobacteria under these concentrations Conclusions/Significance: NPT are the first example of low mol. weight compounds that inhibit the enzymic and biol. activities of Rpf proteins. In the experimental materials used by the author, we found 4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5SDS of cas: 52854-14-5)

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.SDS of cas: 52854-14-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,Molecules included an article by Naboulsi, Imane; Aboulmouhajir, Aziz; Kouisni, Lamfeddal; Bekkaoui, Faouzi; Yasri, Abdelaziz. Application of 213743-31-8. The article was titled 《Combining a QSAR approach and structural analysis to derive an SAR map of Lyn kinase inhibition》. The information in the text is summarized as follows:

Lyn kinase, a member of the Src family of protein tyrosine kinases, is mainly expressed by various hematopoietic cells, neural and adipose tissues. Abnormal Lyn kinase regulation causes various diseases such as cancers. Thus, Lyn represents, a potential target to develop new antitumor drugs. In the present study, using 176 mols. (123 training set mols. and 53 test set mols.) known by their inhibitory activities (IC50) against Lyn kinase, we constructed predictive models by linking their physico-chem. parameters (descriptors) to their biol. activity. The models were derived using two different methods: the generalized linear model (GLM) and the artificial neural network (ANN). The ANN Model provided the best prediction precisions with a Square Correlation coefficient R2 = 0.92 and a Root of the Mean Square Error RMSE = 0.29. It was able to extrapolate to the test set successfully (R2 = 0.91 and RMSE = 0.33). In a second step, we have analyzed the used descriptors within the models as well as the structural features of the mols. in the training set. This anal. resulted in a transparent and informative SAR map that can be very useful for medicinal chemists to design new Lyn kinase inhibitors. The experimental part of the paper was very detailed, including the reaction process of 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Application of 213743-31-8)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 213743-31-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Perez, Miguel A.; Soto, Jose L. published their research in Synthesis on December 31 ,1981. The article was titled 《Synthesis of 6-alkoxy-2-amino-5-cyanopyrimidines through sodium alkoxide-induced regiospecific cyclization of 1,3-dicarbonitriles》.Formula: C7H10N4O2 The article contains the following contents:

The reaction of R1C(OR):C(CN)2 (R = Et, Me; R1 = H, Me, Ph, tolyl, anisyl, ClC6H4, O2NC6H4) with H2NCN and NaOR2-R2OH (R2 = Me, Et, Pr) yielded the resp. pyrimidinecarbonitriles I. Similarly, pyrimidines II were prepared from R1C(OR):C(CN)2, H2NC(OMe):N+H2 Cl-, and NaOMe-MeOH. A mixture of EtOCH:C(CN)2, H2NCH, and NaOMe in MeOH was refluxed to give I (R1 = H, R2 = Me). In the experiment, the researchers used many compounds, for example, Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1Formula: C7H10N4O2)

Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Formula: C7H10N4O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Blue iridium(III) complexes with high internal quantum efficiency based on 4-(pyridin-3-yl)pyrimidine derivative and their electroluminescent properties》 was written by Cheng, Wei; Wang, Li-Ding; Zhou, Yue-Yue; Bian, Zu-Qiang; Tong, Bi-Hai; Liu, Zhi-Wei; Wang, Song. HPLC of Formula: 1193-21-1 And the article was included in Dyes and Pigments in 2020. The article conveys some information:

Three novel highly efficient blue bicyclometalated Ir(III) complexes (Ir1-Ir3) were designed and synthesized with 4-(2,6-difluoropyridin-3-yl)-6-mesitylpyrimidine as primary ligands. The alternation of ancillary ligands had precisely regulated their emitting peaks from sky-blue to deep-blue. These complexes exhibit unimodal emission with PLQYs >90% and lifetimes shorter than 1.1μs. These complexes also show good thermal stability with Td > 320°. The OLED using complex Ir3 as emitter in 13% exhibited a maximum luminous efficiency of 16.9 cd A-1 with a high EQE of 13.0%. The CIE coordinates of this device are (0.15, 0.16), which are close to the standard blue color region. The experimental process involved the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1HPLC of Formula: 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.HPLC of Formula: 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1193-21-1In 2022 ,《Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and Evaluation of Their Antiviral Activity》 appeared in Molecules. The author of the article were Krasnov, Victor P.; Musiyak, Vera V.; Levit, Galina L.; Gruzdev, Dmitry A.; Andronova, Valeriya L.; Galegov, Georgii A.; Orshanskaya, Iana R.; Sinegubova, Ekaterina O.; Zarubaev, Vladimir V.; Charushin, Valery N.. The article conveys some information:

A series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its (S)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of chlorine in various chloropyrimidines. Enantiomeric purity of optically active derivatives was confirmed by chiral HPLC. Antiviral evaluation of the synthesized compounds has shown that the replacement of purine with a pyrimidine fragment leads to a decrease in the anti-herpesvirus activity compared to the lead compound, purine conjugate. The studied compounds did not exhibit significant activity against influenza A (H1N1) virus. After reading the article, we found that the author used 4,6-Dichloropyrimidine(cas: 1193-21-1Application of 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Reexamination of the application of linear free energy relationships to the azaheterocyclic systems. I. Substituent effects on the basicity of monocyclic azines》 was written by Tomasik, P.; Zalewski, R.. Electric Literature of C6H8N2O And the article was included in Chemicke Zvesti on April 30 ,1977. The article conveys some information:

The basicities of pyridines, pyrimidines, pyridazines, and pyrazines (180 compounds) were correlated with substituent effects by Hammett and Taft equations. Limitations of the LFER are discussed. In addition to this study using 2-Methoxy-4-methylpyrimidine, there are many other studies that have used 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Electric Literature of C6H8N2O) was used in this study.

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Electric Literature of C6H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1967,Tetrahedron included an article by Kheifets, G. M.; Khromov-Borisov, N. V.; Kol’tsov, A. I.; Vol’kenhstein, M. V.. Related Products of 15726-38-2. The article was titled 《The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives》. The information in the text is summarized as follows:

The proton N.M.R. spectra of 4,6-dihydroxypyrimidine and its 2- and 5-substituted derivatives have been compared with the spectra of their O- and N-methyl derivatives of fixed structures, corresponding to possible tautomeric forms. In a Me2SO medium the compounds exist predominantly in the oxohydroxy form. In aqueous solutions of 4,6-dihydroxypyrimidine and its N-methyl derivatives the bipolar-ionic form with delocalized charges probably predominates. 22 references. The experimental process involved the reaction of 5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2Related Products of 15726-38-2)

5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 15726-38-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2013,Skardziute, Lina; Kazlauskas, Karolis; Dodonova, Jelena; Bucevicius, Jonas; Tumkevicius, Sigitas; Jursenas, Saulius published 《Optical study of the formation of pyrrolo[2,3-d]pyrimidine-based fluorescent nanoaggregates》.Tetrahedron published the findings.COA of Formula: C6H3Cl2N3 The information in the text is summarized as follows:

Pyrrolo[2,3-d]pyrimidine derivatives possessing different sterically-hindered end-groups at position 7 of the heterocycle were studied and compared with respect to nanoaggregate formation ability by the reprecipitation method in aqueous solutions The emergence of nanoaggregates with an increasing water fraction in THF/water mixture was traced by observing sudden changes in spectral and transient fluorescence dynamics accompanied by fluorescence efficiency turn-on. The aggregation induced emission with a maximal 20-fold emission efficiency enhancement was obtained. Tuning of the nanoaggregates sizes from about 50 nm to 600 nm by increasing the THF/water ratio was revealed by electron microscopy. Almost perfect spherical shapes of the nanoaggregates and their structureless fluorescence bands similar to those of their neat amorphous films suggested an amorphous-like nature of the pyrrolo[2,3-d]pyrimidine-based nanoparticles. After reading the article, we found that the author used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4COA of Formula: C6H3Cl2N3)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. COA of Formula: C6H3Cl2N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Galeta, Juraj; Sala, Michal; Dracinsky, Martin; Vrabel, Milan; Havlas, Zdenek; Nencka, Radim published 《Single-Step Formation of Pyrimido[4,5-d]pyridazines by a Pyrimidine-Tetrazine Tandem Reaction》.Organic Letters published the findings.Application In Synthesis of 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

A straightforward synthesis of pyrimido[4,5-d]pyridazines from pyrimidines and tetrazines under basic conditions is reported. Deprotonated, substituted 5-halopyrimidines readily react with variously substituted tetrazines in a highly regioselective manner via a complex reaction pathway, which was supported by DFT calculations This mechanism leads to the empirically observed regioisomers without going through the conceivable hetaryne intermediate. These results on 5-halopyrimidines led to development of the methodol. for preparation of opposite regioisomers based on 6-halopyrimidines. After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Application In Synthesis of 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Application In Synthesis of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia