Day: October 26, 2022

On February 24, 2005, Kishino, Hiroyuki; Moriya, Minoru; Sakamoto, Toshihiro; Takahashi, Hidekazu; Sakuraba, Shunji; Suzuki, Takao; Kanatani, Akio published a patent.Computed Properties of 85386-20-5 The title of the patent was Preparation of imidazopyridine derivatives as melanin-concentrating hormone receptor antagonists. And the patent contained the following:

Title compounds I [R1, R2 = H, halo, etc., further detail on R1, R2 is given; R3 = H, halo, etc.; R4 = H, alkyl; W = single bond, etc.; Ar = optionally substituted aromatic ring, etc. with R7; R7 = halo, etc.] were prepared For example, Pd-catalyzed hydrogenation of 2-isopropyl-6-nitroimidazo[1,2-a]pyridine hydrobromide followed by HATU-mediated acylation with 4′-fluoro-1,1′-biphenyl-4-carboxylic acid afforded compound II. In MCH (Melanin Concentrating Hormone) binding inhibition assays, the IC50 value of compound II was 3.1 nM. Compounds I are claimed useful for the treatment of obesity, diabetes, etc. The experimental process involved the reaction of 5-Phenylpyrimidine-2-carboxylic acid(cas: 85386-20-5).Computed Properties of 85386-20-5

The Article related to imidazopyridine preparation melanin concentrating hormone mch receptor antagonist, antiobesity agent imidazopyridine preparation mch receptor antagonist, antidiabetic agent imidazopyridine preparation mch receptor antagonist and other aspects.Computed Properties of 85386-20-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adib, Mehdi; Karimi-Nami, Rahman; Veisi, Hojat published an article in 2016, the title of the article was Palladium NPs supported on novel imino-pyridine-functionalized MWCNTs: efficient and highly reusable catalysts for the Suzuki-Miyaura and Sonogashira coupling reactions.Quality Control of 5-(4-Bromophenyl)pyrimidine And the article contains the following content:

In this article a new heterogeneous nanocatalyst based on palladium supported on functionalized multi-walled carbon nanotubes (MWCNTs) has been introduced. The synthetic process of the mentioned nanocatalyst, MWCNT-imino-pyridine/Pd, has been described. The characterization of the MWCNT-imino-pyridine/Pd was afforded by SEM, EDX, TEM, FTIR, ICP, and XRD. The surface structure of the materials was confirmed using Fourier transform IR (FTIR) spectroscopy. The catalytic activity of MWCNT-imino-pyridine/Pd was tested in Sonogashira and Suzuki-Miyaura cross-coupling reactions affording various derivatives of both aryl alkynes and biaryls. The catalyst can be readily recovered and recycled at least six times without significant loss of catalytic activity. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Quality Control of 5-(4-Bromophenyl)pyrimidine

The Article related to palladium nanoparticle supported iminopyridine functionalized mwcnt, efficient highly reusable catalyst suzuki sonogashira coupling reaction, sonogashira suzuki crosscoupling reaction production derivative aryl alkyne biaryl and other aspects.Quality Control of 5-(4-Bromophenyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 2021, McKnight, Ian; Hart, Christoph; Park, In-Hyun; Shim, Joon W. published an article.Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions. And the article contained the following:

A review. Congenital hydrocephalus (CH) is caused by genetic mutations, but whether factors impacting human genetic mutations are disease-specific remains elusive. Given two factors associated with high mutation rates, we reviewed how many disease-susceptible genes match with (i) proximity to telomeres or (ii) high adenine and thymine (A + T) content in human CH as compared to other disorders of the central nervous system (CNS). We extracted genomic information using a genome data viewer. Importantly, 98 of 108 genes causing CH satisfied (i) or (ii), resulting in >90% matching rate. However, such a high accordance no longer sustained as we checked two factors in Alzheimers disease (AD) and/or familial Parkinsons disease (fPD), resulting in 84% and 59% matching, resp. A disease-specific matching of telomere proximity or high A + T content predicts causative genes of CH much better than neurodegenerative diseases and other CNS conditions, likely due to sufficient number of known causative genes (n = 108) and precise determination and classification of the genotype and phenotype. Our anal. suggests a need for identifying genetic basis of both factors before human clin. studies, to prioritize putative genes found in preclin. models into the likely (meeting at least one) and more likely candidate (meeting both), which predisposes human genes to mutations. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to review congenital hydrocephalus alzheimers parkinsons disease dna telomere, alzheimer’s disease, a + t content, mutation, chromosome, homologous recombination, familial parkinson’s disease, congenital hydrocephalus, telomeres and other aspects.Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Tabernero, Josep; Taieb, Julien; Prager, Gerald W.; Ciardiello, Fortunato; Fakih, Marwan; Leger, Catherine; Fougeray, Ronan; Amellal, Nadia; van Cutsem, Eric published an article in 2021, the title of the article was Trifluridine/tipiracil plus bevacizumab for third-line management of metastatic colorectal cancer: SUNLIGHT study design.Related Products of 65-71-4 And the article contains the following content:

Preliminary studies of FTD/TPI plus bevacizumab have produced encouraging results in the treatment of refractory metastatic colorectal cancer. Here, we describe the design of the multinational Phase III SUNLIGHT, an open-label study of FTD/TPI plus bevacizumab as third-line treatment for patients with unresectable metastatic colorectal cancer. A total of 490 patients will be randomized 1:1 to receive either FTD/TPI plus bevacizumab, or FTD/TPI monotherapy. The primary objective is to significantly improve overall survival with FTD/TPI plus bevacizumab compared with FTD/TPI monotherapy. The first patient was enrolled in Nov. 2020. Lay abstract : Trifluridine/tipiracil is a cancer treatment used in patients with bowel cancer that has spread to other parts of the body (this is called ‘metastatic bowel cancer’). This medicine is taken by mouth. Recently, a number of studies have suggested that better results might be obtained when trifluridine/tipiracil is used in combination with another cancer drug, bevacizumab. This article describes the design of a new clin. trial. The SUNLIGHT is being set up to confirm whether the combination of trifluridine/tipiracil plus bevacizumab is indeed better than trifluridine/tipiracil alone for patients who have already had two different treatments for metastatic bowel cancer. The trial began in late 2020. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Related Products of 65-71-4

The Article related to trifluridine tipiracil bevacizumab third management metastatic colorectal cancer sunlight, ftd/tpi, phase iii, bevacizumab, metastatic colorectal cancer, randomized controlled trial, refractory, third line, trifluridine/tipiracil and other aspects.Related Products of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 7, 2021, SenGupta, Tanima; Palikaras, Konstantinos; Esbensen, Ying Q.; Konstantinidis, Georgios; Galindo, Francisco Jose Naranjo; Achanta, Kavya; Kassahun, Henok; Stavgiannoudaki, Ioanna; Bohr, Vilhelm A.; Akbari, Mansour; Gaare, Johannes; Tzoulis, Charalampos; Tavernarakis, Nektarios; Nilsen, Hilde published an article.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. And the article contained the following:

Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, the underlying mechanisms are poorly understood. Here, we show that base excision repair generates genomic stress, promoting age-related neurodegeneration in a Caenorhabditis elegans PD model. A physiol. level of NTH-1 DNA glycosylase mediates mitochondrial and nuclear genomic instability, which promote degeneration of dopaminergic neurons in older nematodes. Conversely, NTH-1 deficiency protects against α-synuclein-induced neurotoxicity, maintaining neuronal function with age. This apparent paradox is caused by modulation of mitochondrial transcription in NTH-1-deficient cells, and this modulation activates LMD-3, JNK-1, and SKN-1 and induces mitohormesis. The dependence of neuroprotection on mitochondrial transcription highlights the integration of BER and transcription regulation during physiol. aging. Finally, whole-exome sequencing of genomic DNA from patients with idiopathic PD suggests that base excision repair might modulate susceptibility to PD in humans. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to caenorhabditis parkinson disease single stranded dna base excision repair, c. elegans, dna-glycosylase, nth-1, parkinson disease, aging, base excision repair, hydrogen peroxide, mitohormesis, neurodegeneration, oxidative dna damage and other aspects.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Abakir, Abdulkadir; Ruzov, Alexey published an article in 2021, the title of the article was Detection of Low-Abundance DNA Modifications Using Signal Amplification-Based Immunocytochemistry.Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione And the article contains the following content:

A review. Immunocytochem. can be instrumental in assessing the spatial distribution and relative levels of epigenetic modifications. Although conventional immunostaining has been utilized for the detection of 5-methylcytosine (5mC) in animal cells and tissues for several decades, the sensitivity of techniques based on the use of fluorophore-conjugated secondary antibodies is not always sufficient for studying DNA modifications that are less abundant in DNA compared with 5mC. Here we describe a protocol for sensitive immunocytochem. that utilizes peroxidase-conjugated secondary antibodies coupled with catalyzed reporter deposition and allows for detection of low-abundance noncanonical bases (e.g., 5-carboxylcytosine, 5caC, 5-formylcytosine, 5fC, 5-hydroxymethyluracil, 5hmU) in mammalian DNA. This method can be employed for evaluation of the levels and nuclear distribution of DNA modifications and permits their colocalization with protein markers in animal cells. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to review dna modification signal amplification immunocytochem, 5-carboxylcytosine, 5-formylcytosine, dna (de)methylation, dna modifications, immunocytochemistry, immunofluorescence, immunohistochemistry, oxi-mcs, signal amplification and other aspects.Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 15, 2012, Matyugina, Elena; Khandazhinskaya, Anastasia; Chernousova, Larisa; Andreevskaya, Sofia; Smirnova, Tatiana; Chizhov, Alexander; Karpenko, Inna; Kochetkov, Sergey; Alexandrova, Ludmila published an article.Product Details of 626-48-2 The title of the article was The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivatives. And the article contained the following:

A series of new carbocyclic uracil derivatives, e.g. I, were synthesized and evaluated as potential antituberculosis agents. Racemic hydroxy-cyclopentenyl-5-tetradecynyluracil I completely inhibited the growth of Mycobacterium tuberculosis H37Rv in vitro at a concentration of 10 μg/mL. Individual (+) and (-) isomers of the above uracil derivative were isolated and showed the same level of activity against two strains of Mycobacterium tuberculosis: laboratory sensitive (H37Rv) and drug resistant to five top antituberculosis drugs (MS-115). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to drug resistance antituberculosis mycobacterium tuberculosis carbocyclic nucleoside preparation, carbocyclic nucleoside uracil preparation antituberculosis hydroxycyclopentenyltetradecynyluracil mycobacterium tuberculosis antibacterial and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 1, 2012, Li, Zhenhua; Wu, Danli; Zhong, Weihui published an article.Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine The title of the article was Facile and efficient cyclization of anthranilonitrile to 2,4-dichloroquinazoline by bis(trichloromethyl) carbonate and catalytic amount triphenylphosphine oxide. And the article contained the following:

2,4-Dichloroquinazolines were synthesized by the cyclization of anthranilonitrile using bis(trichloromethyl)carbonate with the aid of catalytic amount of Ph3PO at 120 °C. This method was also applied to the synthesis of 2,4-dichlorothieno[2,3-d]pyrimidine. The plausible mechanism was presented. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine

The Article related to anthranilonitrile chloromethylcarbonate cyclization phenylphosphine oxide catalyst, aminothiophenonitrile chloromethylcarbonate cyclization phenylphosphine oxide catalyst, chloroquinazoline preparation, chlorothienopyrimidine preparation and other aspects.Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Klinke, Glynis; Richter, Sylvia; Monostori, Peter; Schmidt-Mader, Brigitte; Garcia-Cazorla, Angels; Artuch, Rafael; Christ, Stine; Opladen, Thomas; Hoffmann, Georg F.; Blau, Nenad; Okun, Juergen G. published an article in 2020, the title of the article was Targeted cerebrospinal fluid analysis for inborn errors of metabolism on an LC-MS/MS analysis platform.Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Laboratory investigations of cerebrospinal fluid (CSF) are essential when suspecting an inborn error of metabolism (IEM) involving neurol. features. Available tests are currently performed on different anal. platforms, requiring a large sample volume and long turnaround time, which often delays timely diagnosis. Therefore, it would be preferable to have an one-instrument targeted multi-metabolite approach. A liquid chromatog.-tandem mass spectrometry (LC-MS/MS) platform, based on two different methods for analyzing 38 metabolites using pos. and neg. electrospray ionisation modes, was established. To allow for platform extension, both methods were designed to use the same CSF sample preparation procedure and to be run on the same separation column (ACE C18-PFP). Assessment of the LC-MS/MS platform methods was first made by anal. validation, followed by the establishment of literature-based CSF cut-off values and reference ranges, and by the measurement of available samples obtained from patients with confirmed diagnoses of aromatic -amino acid decarboxylase deficiency, guanidinoacetate methyltransferase deficiency, ornithine aminotransferase deficiency, cerebral folate deficiency and methylenetetrahydrofolate reductase deficiency. An extendable targeted LC-MS/MS platform was developed for the anal. of multiple metabolites in CSF, thereby distinguishing samples from patients with IEM from non-IEM samples. Reference concentrations for several biomarkers in CSF are provided for the first time. By measurement on a single anal. platform, less sample volume is required (200μL), diagnostic results are obtained faster, and preanal. issues are reduced. LC-MS/MS platform for CSF anal. consisting of two differentially designed methods. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to cerebrospinal fluid inborn error metabolism lcms ms analysis, cerebrospinal fluid, inborn errors of metabolism, inherited metabolic diseases, liquid chromatography coupled to tandem mass spectrometry, reference ranges, targeted metabolomics and other aspects.Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 30, 2019, Garlito, Borja; Ibanez, Maria; Portoles, Tania; Serrano, Roque; Amlund, Heidi; Lundebye, Anne-Katrine; Sanden, Monica; Berntssen, Marc H. G.; Hernandez, Felix published an article.Formula: C5H6N2O2 The title of the article was LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients. And the article contained the following:

The composition of Atlantic salmon feed has changed considerably over the last two decades from being marine-based (fishmeal and fish oil) to mainly containing plant ingredients. Consequently, concern related to traditional persistent contaminants typically associated with fish-based feed has been replaced by other potential contaminants not previously associated with salmon farming. This is the case for many pesticides, which are used worldwide to increase food production, and may be present in plant ingredients. Earlier studies have identified two organophosphorus pesticides, chlorpyrifos-Me and pirimiphos-Me, in plant ingredients used for aquafeed production In the present study, we developed a reliable and sensitive anal. method, based on liquid chromatog. coupled to tandem mass spectrometry, for the determination of these pesticides and their main metabolites in warm water (zebrafish) and cold water (Atlantic salmon) species, where possible differences in metabolites could be expected. The method was tested in whole zebrafish and in different salmon tissues, such as muscle, bile, kidney, fat, and liver. The final objective of this work was to assess kinetics of chlorpyrifos-Me and pirimiphos-Me and their main metabolites in fish tissue, in order to fill the knowledge gaps on these metabolites in fish tissues when fed over prolonged time. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Formula: C5H6N2O2

The Article related to lc ms organophosphorus pesticide bioaccumulation metabolite salmon zebrafish, plant based feed contamination salmo danio chlorpyrifos pirimiphos methyl, atlantic salmon, chlorpyrifos-methyl, lc-ms/ms, metabolites, pirimiphos-methyl, zebrafish and other aspects.Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia