Day: October 28, 2022

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 554-01-8, formula is C5H7N3O, Name is 4-Amino-5-methylpyrimidin-2(1H)-one. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Safety of 4-Amino-5-methylpyrimidin-2(1H)-one.

Kim, Dongil;Yoon, Chansik;Lee, Gyun Min research published 《 Small molecule epigenetic modulators for enhancing recombinant antibody production in CHO cell cultures》, the research content is summarized as follows. Small mol. epigenetic modulators that modify epigenetic states in cells are useful tools for regulating gene expression by inducing chromatin remodeling. To identify small mol. epigenetic modulators that enhance recombinant protein expression in Chinese hamster ovary (CHO) cells, we examined eight histone deacetylase inhibitors (iHDACs) and six DNA methyltransferase inhibitors as chem. additives in recombinant CHO (rCHO) cell cultures. Among these, a benzamide-based iHDAC, CI994, was the most effective in increasing monoclonal antibody (mAb) production Despite suppressing cell growth, the addition of CI994 to mAb-expressing GSR cell cultures at 10μM resulted in a 2.3-fold increase in maximum mAb concentration due to a 3.0-fold increase in specific mAb productivity (qmAb). CI994 increased mAb mRNA levels and histone H3 acetylation in GSR cells, and chromatin immunoprecipitation-quant. polymerase chain reaction anal. revealed that CI994 significantly increased the histone H3 acetylation level at the cytomegalovirus promoter driving mAb gene expression, indicating that chromatin remodeling in the promoter region results in enhanced mAb gene transcription and qmAb. Similar beneficial effects of CI994 on mAb production were observed in mAb-expressing CS13-1.00 cells. Collectively, our findings indicate that CI994 increases mAb production in rCHO cell cultures by chromatin remodeling resulting from acetylation of histones in the mAb gene promoter.

Safety of 4-Amino-5-methylpyrimidin-2(1H)-one, 5-Methylcytosine is a methylated form of the nucleobase cytosine occurring predominantly in cytosine-phosphate-guanine (CpG) islands that are produced by DNA methyltransferases and may regulate gene expression. Like cytosine, the DNA sequence containing 5-methylcytosine (5-mC) is able to be replicated without error and 5-mC can pair with guanine in double stranded DNA. However, DNA sequences containing a high local concentration of 5-mC may be less transcriptionally active than areas with higher ratios of unmodified cytosine.
5-Methylcytosine belongs to the class of organic compounds known as hydroxypyrimidines. These are organic compounds containing a hydroxyl group attached to a pyrimidine ring. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. 5-Methylcytosine exists as a solid, slightly soluble (in water), and a very weakly acidic compound (based on its pKa). Within the cell, 5-methylcytosine is primarily located in the cytoplasm. 5-Methylcytosine can be biosynthesized from cytosine. Outside of the human body, 5-methylcytosine can be found in tea. This makes 5-methylcytosine a potential biomarker for the consumption of this food product.
5-methylcytosine is a pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position. It has a role as a human metabolite. It is a member of pyrimidines and a methylcytosine. It derives from a cytosine.
5-Methylcytosine is a nucleic acid that is found in the DNA and RNA of the cell. It is an important component of methylation, which is the process by which a methyl group is added to a molecule. This process can lead to cellular transformation, a process that can cause cancer. 5-Methylcytosine has also been shown as a molecular pathogenesis factor in infectious diseases such as HIV and herpes simplex virus type 1. The presence of 5-methylcytosine in nuclear DNA has been detected by analytical techniques such as gas chromatography/mass spectrometry (GC/MS). There are many analytical methods, including GC/MS, that can be used to detect 5-methylcytosine in cellular nuclei., 554-01-8.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 554-01-8, formula is C5H7N3O, Name is 4-Amino-5-methylpyrimidin-2(1H)-one. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. COA of Formula: C5H7N3O.

Khoshfetrat, Seyyed Mehdi;Dorraji, Parisa Seyed;Fotouhi, Lida;Hosseini, Mehdi;Khatami, Fatemeh;Moazami, Hamid Reza;Omidfar, Kobra research published 《 Enhanced electrochemiluminescence biosensing of gene-specific methylation in thyroid cancer patients′ plasma based integrated graphitic carbon nitride-encapsulated metal-organic framework nanozyme optimized by central composite design》, the research content is summarized as follows. Circulating cell free DNA (cfDNA) methylation is a novel type of cancer biomarker, but its minuscule proportion of total DNA makes proper anal. difficult in clin. samples. Herein, a sensitive electrochemiluminescence immuno-DNA sensor was designed to analyze DNA methylation using sandwiching the target methylated DNA between the magnetic nanoparticles/anti-5-methylcytosine monoclonal antibody (MNPs/anti-5mc) bioconjugate and luminol-loaded within phosphorylated DNA capture probe-immobilizedC₃N₄ NS@UiO-66 core@shell nanozyme. Taking advantages of increased concentration of C₃N₄ NS nanozymes′ ·OH-generation, nanoproximity effect of C₃N₄ NS and luminol, high d. coordination of capture probe on the UiO-66 metal organic framework (MOF), MNPs′ function in improving the signal-to-background ratio (S/B) in complicated plasma media, and remarkable electrocatalytic activity of reduced graphene oxide-modified pencil graphite electrode (rGO/PGE), multiple signal amplification was achieved without bisulfite and PCR amplification. The immuno-DNA sensor offers a linear response across a wide dynamic range from 20 pg to 20 ng, with a detection limit of 10 pg, when optimized by a face-centered central composite design (FCCD). Our method can differentiate methylation levels as low as 0.1%. Tumor-specific methylation DNA is definitely identified in the plasma of 9 of 10 thyroid cancer patients′ plasma. The 91% clin. sensitivity implies strong clin. diagnosis consistency. The suggested method was successfully utilized to evaluate methylated DNA in human blood plasma, demonstrating the platform′s potential for disease diagnostics and biochem. research.

554-01-8, 5-Methylcytosine is a methylated form of the nucleobase cytosine occurring predominantly in cytosine-phosphate-guanine (CpG) islands that are produced by DNA methyltransferases and may regulate gene expression. Like cytosine, the DNA sequence containing 5-methylcytosine (5-mC) is able to be replicated without error and 5-mC can pair with guanine in double stranded DNA. However, DNA sequences containing a high local concentration of 5-mC may be less transcriptionally active than areas with higher ratios of unmodified cytosine.
5-Methylcytosine belongs to the class of organic compounds known as hydroxypyrimidines. These are organic compounds containing a hydroxyl group attached to a pyrimidine ring. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. 5-Methylcytosine exists as a solid, slightly soluble (in water), and a very weakly acidic compound (based on its pKa). Within the cell, 5-methylcytosine is primarily located in the cytoplasm. 5-Methylcytosine can be biosynthesized from cytosine. Outside of the human body, 5-methylcytosine can be found in tea. This makes 5-methylcytosine a potential biomarker for the consumption of this food product.
5-methylcytosine is a pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position. It has a role as a human metabolite. It is a member of pyrimidines and a methylcytosine. It derives from a cytosine.
5-Methylcytosine is a nucleic acid that is found in the DNA and RNA of the cell. It is an important component of methylation, which is the process by which a methyl group is added to a molecule. This process can lead to cellular transformation, a process that can cause cancer. 5-Methylcytosine has also been shown as a molecular pathogenesis factor in infectious diseases such as HIV and herpes simplex virus type 1. The presence of 5-methylcytosine in nuclear DNA has been detected by analytical techniques such as gas chromatography/mass spectrometry (GC/MS). There are many analytical methods, including GC/MS, that can be used to detect 5-methylcytosine in cellular nuclei., COA of Formula: C5H7N3O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Quality Control of 4595-59-9.

Khandaka, Himanshu;Sharma, Kamal Nayan;Joshi, Raj Kumar research published 《 Aerobic Cu and amine free Sonogashira and Stille couplings of aryl bromides/chlorides with a magnetically recoverable Fe₃O₄@SiO₂ immobilized Pd(II)-thioether containing NHC》, the research content is summarized as follows. Two value added C-C cross coupling reactions; Sonogashira and Stille couplings were achieved at milder conditions in the catalytic presence of a magnetically recoverable heterogeneous catalyst Fe₃O₄@SiO₂ immobilized Pd(II)-thioether containing NHC. The catalyst was earlier reported for Suzuki-Miyaura reaction and as an extension of its catalytic efficiency, the Stille and Sonogashira cross coupling reactions under aerobic condition had been explored in present report. The Sonogashira coupling of aryl bromides and terminal alkynes produced an excellent yield (∼96% at 0.25 mol% Pd) of the desired coupling product under copper and amines free conditions. Moreover, an excellent Stille coupling of readily available and more latent aryl chlorides and trialkylstannane was obtained (yields up to 95% at 0.25 mol% Pd) in absence of toxic fluorides additives. The broad substrate scope of the catalyst for both the coupling reactions and the magnetically recoverable feature of catalyst made this reaction highly desirable for industrial applications of present heterogeneous catalysis.

Quality Control of 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Related Products of 4595-59-9.

Khan, Ilham;Khalid, Muhammad;Adeel, Muhammad;Khan, Muhammad Usman;Khan, Muhammad Sohail;Ahmad, Naseeb;Ali, Akbar;Akram, Muhammad research published 《 Palladium-catalyzed synthesis of pyrimidine substituted diaryl ethers through Suzuki Miyaura coupling reactions: Experimental and DFT studies》, the research content is summarized as follows. Aryl and hetero-aryl substituted pyrimidine derivatives demonstrate widespread applications in nonlinear optics (NLO), agrochem. and therapeutic drugs. Therefore, 2-(4-phenoxyphenyl)pyrimidine (2-PPP) and 5-(4-phenoxyphenyl) pyrimidine (5-PPP) were synthesized by palladium-catalyzed Suzuki coupling approach. The structure elucidation of synthesized products was done by ¹H-NMR, ¹³C-NMR, and UV-vis spectroscopic analyses. The natural bond orbital (NBO) anal. was performed using d. functional theory (DFT) assisted M06/6-311G** functional, which confirmed the existence of delocalization process and the hyper-conjugative interaction with representative transitions as π(C10-N16)→π*(C14-N17) and π(C26-N30)→π*(C9-N31) having stabilization energies of 36.30 and 36.55 kcal/mol for 2-PPP and 5-PPP, resp. The small energy ΔE LUMO HOMO gap as 5.330 eV in 2-PPP and 4.975 eV in 5-PPP was evident from the frontier MO (FMO) anal., computed at TD-DFT/M06/6-311G** level, Both the NBO and the FMO anal. predicted promising NLO mol. response. Furthermore, HF, LC-BLYP, CAM-B3LYP, M06-2X, and M06 methods, along with the 6-311G** basis set, were utilized to acquire the NLO findings of 2-PPP and 5-PPP. M06 and HF methods indicated the largest and lowest values of average polarizability α and first hyperpolarizability (β_tot), resp. for both the compounds 2-PPP and 5-PPP. The α and β_tot values of 2-PPP and 5-PPP were observed as 7.0 and 7.3 times and 15 and 36 times higher than the urea mol., resp. Both compounds hold fine NLO characteristics, thus recommended for future NLO applications.

Related Products of 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Safety of 5-Bromopyrimidine.

Khan, Ilham;Khalid, Muhammad;Adeel, Muhammad;Niaz, Shah Irum;Shafiq, Iqra;Muhammad, Shabbir;Braga, Ataualpa Albert Carmo research published 《 Palladium-catalyzed synthesis of 5-(arylated) pyrimidines, their characterization, electronic communication, and non-linear optical evaluations》, the research content is summarized as follows. In this study, new derivatives of pyrimidines I [R¹ = 4-methylsulfanyl, 4-Ph, 4-trifluoromethoxy, 2,3-dichloro] were synthesized through Suzuki-Miyaura coupling and assessed by ¹H NMR, ¹³C NMR, FT-IR and UV/Visible anal. Furthermore, computational study such as spectroscopic, frontier MO (FMO), natural bond orbital (NBO) and the mol. electrostatic potential (MEP) was performed at M06/6-311G** to obtain comprehensive insights into electronic communications and the structural property relationship for synthesized compounds I. The maximum exptl. absorption (λ_Exp) for compounds I [R¹ = 4-Ph, 4-methylsulfanyl, 4-trifluoromethoxy, 2,3-dichloro] was obtained at 260, 301, 248, and 233 nm, resp. in methanol, which displayed good agreement with theor. (λ_DFT) result 279, 298, 247, and 233 nm, resp. Moreover, different functional(s) such as HF, M06, M062X, CAM-B3LYP, and LC-BLYP with basis sets 6-311G** were utilized to compute the average polarizability α, total dipole moment (μ_tot) and hyperpolarizability (β_tot) values. Among the tested methods, highest μ_tot value (3.5465 D) was observed for compoundI [R¹ = 2,3-dichloro] and the lowest value (0.2680 D) for compound I [R¹ = 4-trifluoromethoxy] through HF method. Consequently, the LC-BLYP method also showed the highest μ_tot value (3.4689 D) for compound I [R¹ = 2,3-dichloro] and the lowest value (0.3123 D) of compound I [R¹ = 4-trifluoromethoxy]. Moreover, other methods: CAM-B3LYP, M062X, and M06 showed almost similar values for all compounds I with similar trends. The M06 method showed the largest α values (190.779, 149.331, 130.430 and 138.964 a.u.) for compounds I [R¹ = 4-Ph, 4-methylsulfanyl, 4-trifluoromethoxy, 2,3-dichloro] resp. In contrast, the HF method showed the least α values (178.166, 140.356, 121.848, and 128.994 a.u.) for compounds I [R¹ = 4-Ph, 4-methylsulfanyl, 4-trifluoromethoxy, 2,3-dichloro] resp. The other methods (CAMB3LYP, M062X, and LC-BLYP) indicated nearly parallel (α) values. Moreover, the (β_tot) values (604.898, 344.234, 41.628, and 299.958 a.u.) obtained with M06 method for compounds I [R¹ = 4-Ph, 4-methylsulfanyl, 4-trifluoromethoxy, 2,3-dichloro] resp., were higher compared with urea (β_tot = 69.399 a.u.).

Safety of 5-Bromopyrimidine, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Related Products of 1722-12-9.

Khake, Shrikant M.;Yamazaki, Ken;Ano, Yusuke;Chatani, Naoto research published 《 Iridium(III)-Catalyzed Branch-Selective C-H Alkenylation of Aniline Derivatives with Alkenes》, the research content is summarized as follows. A Ir(III)-catalyzed branch-selective C-H alkenylation of aniline derivatives containing a pyrimidine-directing group with vinylsilanes and terminal aliphatic alkenes to obtain N-(2-(1-(silyl)vinyl)phenyl)pyrimidin-2-amines I [R = Me, Et, OTMs; R¹ = Me, Et, OTMs; R² = Me, Et, Ph; R³ = H, 2-Me, 2,3-(Me)₂, etc.] and N-(2-(alkenyl)-methylphenyl)pyrimidin-2-amines II [R⁴ = n-Bu, tBu, Cy, etc.] was reported. The reaction provided a broad substrate scope for aniline derivatives, and a variety of functional groups are tolerated. D. functional theory calculations were performed in an attempt to understand the origin of the branch selectivity.

Related Products of 1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., 1722-12-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 65-86-1, formula is C5H4N2O4, Name is 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Synthetic Route of 65-86-1.

Keerthisinghe, Tharushi Prabha;Yang, Qin;Chow, Agnes;Fang, Mingliang research published 《 Feeding state greatly modulates the effect of xenobiotics on gut microbiome metabolism: A case study of tetracycline》, the research content is summarized as follows. The human gut microbiome is crucial in modulating host health mostly through bacterial metabolites. Chem. exposure is typical external stress which alters its composition and functionality. To date, very few studies have investigated the effect of feeding state on chem.-induced gut microbial metabolic dysregulations. Here, we set up an in vitro human gut microbiome and incorporated a metabolomics approach to investigate the effect of tetracycline (TET) at multiple doses (i.e., 10, 1, and 0.01 mg/L) on gut microbiome under the fed and fasted states. Overall, the metabolome was highly responsive at the fed state with 62 metabolites dysregulated while only 14 were altered at the fasted state under 10 mg/L (clin. TET dose). As expected, nutrient consumption was significantly inhibited under clin. TET dose at the fed state accumulating nutrients such as glutamate and leucine. Interestingly, at the fed state, TET could increase the synthesis of indole and Ph derivatives including indole-3-aldehyde and hydrocinnamate, while inhibiting indoxyl, tryptamine, and vitamin B production, all of which have host health implications. Furthermore, metabolites like indoxyl and xanthurenic acid were still responsive at 0.01 mg/L (dietary TET dose). Collectively, results demonstrated that the feeding state greatly modulates the chem.-induced gut microbial metabolic alterations.

Synthetic Route of 65-86-1, Orotic acid anhydrous is a hydrogen bonding interaction that can be found in biological systems. It plays a role in the physiological effects of orotic acid, which is a metabolite of uridine and an intermediate in the synthesis of pyrimidine nucleotides. Orotic acid has antimicrobial properties and has been shown to inhibit enzyme activities involved in energy metabolism, such as polymerase chain reaction (PCR) and adenosine triphosphate (ATP) synthase. Orotic acid also inhibits the growth of bacteria, fungi, and parasites. Orotic acid anhydrous is used for treating myocardial infarcts or brain functions. The untreated group was given no treatment at all.
Orotic acid, also known as orotate or orotsaeure, belongs to the class of organic compounds known as pyrimidinecarboxylic acids. These are pyrimidines with a structure containing a carboxyl group attached to the pyrimidine ring. Orotic acid exists as a solid, slightly soluble (in water), and a moderately acidic compound (based on its pKa). Orotic acid has been found in human liver and pancreas tissues, and has also been primarily detected in saliva, feces, urine, and blood. Within the cell, orotic acid is primarily located in the cytoplasm and mitochondria. Orotic acid exists in all eukaryotes, ranging from yeast to humans. Orotic acid participates in a number of enzymatic reactions. In particular, Orotic acid can be biosynthesized from L-dihydroorotic acid and quinone; which is mediated by the enzyme dihydroorotate dehydrogenase (quinone), mitochondrial. In addition, Orotic acid and phosphoribosyl pyrophosphate can be converted into orotidylic acid through its interaction with the enzyme uridine monophosphate synthetase isoform a. In humans, orotic acid is involved in the pyrimidine metabolism pathway. Orotic acid is also involved in several metabolic disorders, some of which include the mngie (mitochondrial neurogastrointestinal encephalopathy) pathway, dihydropyrimidinase deficiency, UMP synthase deficiency (orotic aciduria), and Beta ureidopropionase deficiency. Outside of the human body, orotic acid can be found in a number of food items such as green vegetables, alaska blueberry, chickpea, and colorado pinyon. This makes orotic acid a potential biomarker for the consumption of these food products. Orotic acid is a potentially toxic compound. Orotic acid has been found to be associated with several diseases known as phosphoenolpyruvate carboxykinase deficiency 1, cytosolic and hyperornithinemia-hyperammonemia-homocitrullinuria; orotic acid has also been linked to several inborn metabolic disorders including n-acetylglutamate synthetase deficiency, lysinuric protein intolerance, and ornithine transcarbamylase deficiency.
Orotic acid appears as white crystals or crystalline powder.
Orotic acid is a pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6. It has a role as a metabolite, an Escherichia coli metabolite and a mouse metabolite. It derives from a uracil. It is a conjugate acid of an orotate., 65-86-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Name: Pyrimidin-2-amine.

Keel, Katarina L.;Tepe, Jetze J. research published 《 Total Synthesis of Nortopsentin D via a Late-Stage Pinacol-like Rearrangement》, the research content is summarized as follows. Nortopsentin D is part of a class of bis(indole) alkaloids known for their biol. activity, including inhibitory activity in tumoral cells and antifungal activity. Herein we describe the first total synthesis of nortopsentin D, in which amidine and dione undergo a pivotal condensation and subsequent cyclization via a pinacol-like rearrangement. This synthesis represents a unique strategy for the formation of 5,5-disubstituted (4H)-imidazol-4-one containing natural products, many of which have yet to succumb to total synthesis.

Name: Pyrimidin-2-amine, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Computed Properties of 109-12-6.

Kaur, Pardeep;Sharma, Sunita;Gaba, Jyoti research published 《 Preparation and Biological Activities of Novel Cuminaldehyde Derivatives》, the research content is summarized as follows. Condensation reactions of cuminaldehyde with different primary amines, thiosemicarbazides and hydrazines in the presence of catalytic amounts of glacial acetic acid yielded the resp. Schiff bases, thiosemicarbazones and hydrazones, resp. The new compounds were fully characterized and were screened for their antioxidant potential via the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay and for their antimicrobial activity against three gram neg. bacteria (Pseudomonas sp., Klebsiella sp. and Enterobacter sp.). The new Schiff bases demonstrated higher antioxidant potentials as compared to their thiosemicarbazone and hydrazone counterparts. Compounds 4-i-PrC₆H₄CH:NR [R = 4-hydroxyphenyl and 3-methylpyridin-2-yl] showed promising antioxidant activities at higher concentrations Compounds 4-i-PrC₆H₄CH:NR [R = pyrimidin-2-yl], 4-i-PrC₆H₄CH:NNHC(:S)NHPh, and 4-i-PrC₆H₄CH:NNHR” [R” = 2,4-dinitrophenyl] showed significant activities against Pseudomonas sp., Klebsiella sp., and Enterobacter sp., resp.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Computed Properties of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. COA of Formula: C4H5N3.

Kaur, Manpreet;Singh, Rahul;Patil, Madhuri T.;Kumar, Kushvinder;Sahoo, Subash Chandra;Singh, Kamal Nain;Chaudhari, Vinod D.;Salunke, Deepak B. research published 《 Microwave-assisted Groebke-Blackburn-Bienayme multicomponent reaction to synthesize imidazo fused heterocycles via in-situ generated isocyanides from N-formylamines: An undergraduate organic laboratory experiment》, the research content is summarized as follows. A one-pot methodol. was developed for the direct conversion of N-formylamine, 2-amino pyridine, and aldehyde into 2,3-substituted imidazo[1,2-a]pyridine heterocycles using I₂-PPh₃-Et₃N reagent system under microwave irradiation During the reaction, I₂-PPh₃-Et₃N converts N-formylamine into isocyanide, which in the presence of in-situ generated hydrogen iodide (HI) undergoes Groebke-Balckburn-Bienayme (GBB) multicomponent reaction with aldehyde and 2-aminopyridine. The in-situ generated HI eliminates the need for an external catalyst for the GBB reaction. The developed process incorporates the use of readily accessible and cheap reagents and also avoid a sep. step for the synthesis of isocyanides having disagreeable odor. Fourteen different GBB based heterocycles was synthesized to demonstrate the feasibility of the optimized protocol. The preparation of N-formylamines utilized in the synthesis wass also elaborated and the overall process was optimized to be suitable for a typical undergraduate organic laboratory experiment One of the final products was characterized using FT-IR, ¹H NMR, ¹³C NMR, DEPT, COSY, HSQC, HRMS, and single-crystal X-ray diffraction. Overall, the experiment will be useful in the organic chem. curriculum to teach about multicomponent reactions, the importance of isocyanides in organic synthesis, formylation of amines, application of microwave irradiation in organic synthesis, and structural elucidation of small organic mols.

COA of Formula: C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia