Day: November 2, 2022

On September 18, 2014, Amans, Dominique; Atkinson, Stephen John; Harrison, Lee Andrew; Hirst, David Jonathan; Law, Robert Peter; Lindon, Matthew; Preston, Alexander; Seal, Jonathan Thomas; Wellaway, Christopher Roland published a patent.Application of 596114-50-0 The title of the patent was Preparation of acylaminotetrahydroquinoline derivatives for use as bromodomain inhibitors. And the patent contained the following:

Title compounds I [A = NH, O, S, SO, etc.; V = (un)substituted Ph, heteroaromatic, or pyridone; W and Z independently = CH or N; X or Y independently = C or N; R1 = alkyl; R2 = alkyl, cycloalkyl, heterocyclyl, CH2CF3, or CH2OMe; R3 = alkyl, CH2F, CH2OH, or CH2OC(O)Me; R4 = absent, H, OH, halo, CN, CO2H, etc.; R5 = absent, H, halo, OH, or alkoxy], and their pharmaceutically acceptable salts, are prepared and disclosed as bromodomain inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in BRD4 BD2 TR-FRET assays, e.g., II demonstrated a pIC50 value of ≥7.0. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Application of 596114-50-0

The Article related to quinoline acylaminotetrahydro preparation bromodomain inhibitor, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Application of 596114-50-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 11, 1987, Jooji, Eru Euansu; Debora, Eru Deuookusu published a patent.Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Pathogenic Neisseria-specific growth medium and its use in clinical diagnosis. And the patent contained the following:

A medium containing vancomycin (I) and lincomycin (II) for selectively growing Neisseria is prepared Its use in clin. diagnosis of pathogenic Neisseria such as N. gonorrhoeae or N. meningitidis is also disclosed. An agar medium containing GC agar base 36.0, Hb 10.0 g/L, Isovitalex enrichment 10.0 mL/L, I 2.0 mg/L, II 1.0, colistin sulfate 7.5, trimethoprim 5.0, amphotericin B 5.0 μg/L, and nystatin 1250 units/L was prepared and tested for its selectivity. The growth of N. gonorrhoeae and N. meningitidis was excellent while growth of other microorganisms such as yeast was inhibited. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to neiserria pathogen selection culture medium, vancomycin lincomycin neiserria pathogen selection, Fermentation and Bioindustrial Chemistry: Methods (Including Analysis) and other aspects.Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Stone, K. John published an article in 1976, the title of the article was The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats.Formula: C17H24N4O6 And the article contains the following content:

The reduction of 7,8-dihydrobiopterin (I) to 5,6,7,8-tetrahydrobiopterin by tetrahydrofolate dehydrogenase (EC 1.5.1.3) purified from rat liver was competitively inhibited by trimethoprim lactate (II) (0.36-50.mu.M, Ki 0.285.mu.M). The apparent Km for I was 430 times higher than that for dihydrofolate; reduction of I is thus more susceptible to inhibition by II than is dihydrofolate. I.p. administration of II had no effect on the hepatic supply of tetrahydrobiopterin in rats. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Formula: C17H24N4O6

The Article related to liver tetrahydrofolate dehydrogenase tetrahydrobiopterin, trimethoprim liver tetrahydrofolate dehydrogenase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Formula: C17H24N4O6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 7, 2021, Krajewski, Allison E.; Lee, Jeehiun K. published an article.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Gas-phase experimental and computational studies of 5-halouracils: Intrinsic properties and biological implications. And the article contained the following:

The gas-phase acidity and proton affinity (PA) of 5-halouracils (5-fluorouracil, 5-chlorouracil, 5-bromouracil, and 5-iodouracil) have been examined using both theor. and exptl. methods. This work represents a comprehensive study of the thermochem. properties of these nucleobases. Other than 5-fluorouracil acidity, the intrinsic acidity and PA of these halouracils have not been heretofore measured; these new exptl. data provide a benchmark for the computational values. Furthermore, we examine these 5-halouracils in the context of the enzyme thymine DNA glycosylase (TDG), which is an enzyme that protects the genome by cleaving these substrates from DNA. Our gas-phase results are compared and contrasted to TDG excision rates to afford insights into the TDG mechanism. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to human thymine dna glycosylase mechanism 5 halouracil antitumor agent, halouracil gas phase acidity proton affinity thymine dna glycosylase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 11, 2015, Liang, Ruiyong; Gao, Hai published a patent.COA of Formula: C17H24N4O6 The title of the patent was An aqueous environmentally-friendly abrasion resistant coating. And the patent contained the following:

The title coating is prepared from alkyd resin 90-100, 1, 2- dimethoxyethane 1-2, aluminum borate whisker 3-5, volcanic ash 1-2, expanded perlite 3-4, polyvinyl alc. 2-3, dimethylaminopropylamine 0. 6-1, calcium naphthenate 0. 5-1, isooctyl methacrylate 2-4, magnesium stearate 1-3, manganese sulfate 0. 5-1, aluminum sulfate 1-2, stearic acid 0. 7-1, wollastonite powder 8-12, flame retardant additive 2-4, STPP 1-2, and deionized water 80-100 weight parts. The title coating is produced by mixing volcanic ash, expanded perlite and wollastonite powder, ball milling uniformly to obtain the grinding material; adding STPP into water, stirring uniformly, adding stearic acid and calcium naphthenate, stirring at 30-40 °C for 5-7 min to obtain the activation solution; adding the grinding material into the activation solution, stirring uniformly, adding dimethylaminopropylamine, stirring and dispersing at 100-200 rpm for 20-30 min to obtain the pre-mixture; mixing polyvinyl alc., Mn sulfate and Al sulfate, stirring and mixing at 50-60 °C for 3-5 min, adding above pre-mixture, stirring uniformly, adding 1,2-dimethoxyethane, the left deionized water and alkyd resin, stirring and dispersing at 300-400 rpm for 1-2 h, mixing with the left raw materials, stirring and dispersing at 600-1000 rpm for 20-30 min to obtain the title coating product. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).COA of Formula: C17H24N4O6

The Article related to alkyd resin abrasion resistant coating, Coatings, Inks, and Related Products: Polyester and Alkyd Resin Coatings and other aspects.COA of Formula: C17H24N4O6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 3, 2021, Guo, Jianhua; Li, Mengru; Lu, Ying; Sun, Yue published a patent.Recommanded Product: 160377-42-4 The title of the patent was Preparation of compounds containing benzo five membered heterocycles and organic electroluminescent devices. And the patent contained the following:

The invention discloses a preparation of compounds containing benzo five membered heterocycles and organic electronic devices, which improves the luminous efficiency of the device and prolongs the service life of the device. The compounds containing benzo five membered heterocycles were shown in formula I, Y is selected from any one of O atom, S atom, C (Rx) 2 and N(Ry); the Rx and Ry are the same or different from each other, and are independently selected from hydrogen, deuterium, cyano, nitro, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C3-C12 cycloalkyl, substituted or unsubstituted C6-C30 aryl, substituted or unsubstituted C3-C30 heteroaryl any one of the rings formed by the condensation of the substituted or unsubstituted aliphatic ring of C3- C30 and the aromatic ring of C6- C30; the two adjacent Rx can be connected to form a substituted or unsubstituted ring, or any of Rx and Ry can be directly bonded with L0; when the Rx and Ry are directly bonded with L0, the Rx and Ry are independently selected from any one of single bond, substituted or unsubstituted C6-C30 arylene, substituted or unsubstituted heteroarylene; the Z is selected from any one of O atom and S atom; the Ar1 is selected from substituted or unsubstituted C3-C12 cycloalkyl, substituted or unsubstituted C3-C12 heterocycloalkyl, etc. The title compound was prepared by a multi-step reaction. The invention discloses an organic electroluminescent device, which comprises the components containing benzo five member heterocycles. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Recommanded Product: 160377-42-4

The Article related to benzo five membered heterocycle organic electroluminescent device suzuki coupling, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Recommanded Product: 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 30, 2015, Akbarzadeh, Marzieh; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Tajabadi, Javad published an article.Category: pyrimidines The title of the article was Synthesis of dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepines; derivatives of a novel ring system. And the article contained the following:

Several derivatives of the novel dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine ring system I (NR1 = piperidinyl, morpholinyl, pyrrolidino, etc.) have been synthesized through the initial heterocyclization of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with o-aminothiophenol followed by treatment with various secondary amines in boiling ethanol. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Category: pyrimidines

The Article related to dihydrobenzopyrimidothiazepine preparation, chloromethylmethylpyrimidine aminothiophenol heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 25, 2015, Fei, Xianchao published a patent.Computed Properties of 23256-42-0 The title of the patent was One kind of plastic-rubber composite sheet. And the patent contained the following:

The present invention discloses a plastic-rubber composite sheet material, characterized in that it is composed of the following parts by weight of raw materials: high-d. polypropylene 102-110, dihydrated gypsum powder 3-5, benzalkonium bromide 0. 2-0. 4, anhydrous calcium chloride 2-3, di-sec-octyl phthalate 2-4, table salt 0. 4-1, precipitated silica 5-8, calcium ricinoleate 2-3, trimethoprim lactate 0. 4-1, hexafluoroacetylacetone 0. 3-1, illite powder 6-9, polyurethane 1-2, ammonium chloride 0. 2-1, non-woven fabric crushing materials 6-10, thermoplastic styrene-butadiene rubber 2-4, divinylbenzene 1-2, and anticorrosive additive 1-2 weight parts. The anticorrosive additive is composed of polymethyl methacrylate 30-40, diacetone acrylamide 0.3-1, Et silicate 1-2, Ca propionate 3-5, dihydroacetic acid 2-3, ammonium metavanadate 0.8-1, anhydrous ethanol 4-6 and lauryl di-Me amine oxide 0.3-1 weight parts. The anticorrosive additive is prepared by adding Et silicate into anhydrous ethanol, stirring uniformly to obtain the alc. ester solution; mixing dihydroacetic acid and Ca propionate, ball milling uniformly, adding into deionized water, stirring uniformly, adding lauryl di-Me amine oxide, stirring uniformly to obtain the dispersion solution; heating the polymethyl methacrylate to 100-105°C, adding alc. ester solution, stirring uniformly, adding diacetone acrylamide, keeping the temperature and stirring for 1-2 h, adding dispersion solution, stirring and mixing at 200-300 r/min for 10-20 min, adding the left raw materials, completely stirring and dewatering, and drying at 70-80°C for 3-5 min to obtain the anticorrosive additive. The preparation method of the plastic-rubber composite sheet includes preheating thermoplastic styrene-butadiene rubber and non-woven fabric crushing materials at 110-115°C for 10-20 min, adding di-sec-octyl phthalate, stirring to 50-60°C to obtain esterification material, keeping the temperature; mixing anhydrous calcium chloride and calcium ricinoleate, stirring uniformly, adding polyurethane, stirring and mixing at 60-70°C for 6-10 min, adding the above esterification material, completely mixing, adding table salt, melting, extruding, cooling, grinding into powder; mixing the powder and left raw materials, extruding and molding by the sheet extruder. The sheet of the present invention has high elongation at break and tensile strength, readily available raw materials, low cost, simple technique, no three wastes emission during production, and can effectively promote the compatibility between materials and improve product stability and mech. properties by adding SBR. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0

The Article related to polypropylene butadiene styrene rubber composite, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Computed Properties of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 24, 2015, Dai, Liang published a patent.Formula: C17H24N4O6 The title of the patent was Boron carbide filling-modified plastic and preparation method thereof. And the patent contained the following:

Title plastic is composed of LDPE 100, nano antimony tin oxide 4.5-6.8, nano titanium dioxide 1-2, epoxy soybean oil 2-3, stalk ashes 1-3, nano silica 0.4-0.8, trimethoprim lactate 0.1-0.3, barium chromate 0.2-0.4, boron carbide 0.4-0.5, maleic anhydride grafted compatibilizer 1.2-1.6 weight parts, and appropriate amount of dehydrated alc. Title method includes the following steps: calcining nano antimony tin oxide and nano titanium dioxide at 620-810°C for 30-50 min, cooling, placing in a three-neck flask, adding anhydrous ethanol and maleic anhydride grafted compatibilizer, stirring evenly, and heating at reflux for 4-5 h, centrifuging, washing with anhydrous ethanol for 2-3 times, and vacuum drying at 80°C; adding stalk ashes and nano silica to the above product, and mixing evenly to prepare mixed powder; adding low-d. polyethylene to the high-speed mixing and dispersing machine, adding the mixed powder, boron carbide and other remaining ingredients, mixing and dispersing for 15-20 min, pouring into a twin-screw extruder, extruding and granulating. The prepared plastic has improved wear resistance, good heat stability, UV irradiation resistance, aging resistance, high intensity and chem. resistant properties, is deeply processed into plastic film used for green house of vegetables, has short degradation cycle, strong lower temperature resistance, obvious effect of heat insulation, self-cleaning and antibacterial property, and high transmittance. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Formula: C17H24N4O6

The Article related to ldpe oxide epoxy soybean oil trimethoprim lactate, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Formula: C17H24N4O6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2019, Gainullina, Yu. Yu.; Gus’kov, V. Yu.; Timofeeva, D. V. published an article.Synthetic Route of 626-48-2 The title of the article was Polarity of Thymine and 6-Methyluracil-Modified Porous Polymers, According to Data from Inverse Gas Chromatography. And the article contained the following:

Abstract: The affinity of surfaces of porous polymer Polysorb-1 samples modified with thymine (5-methyluracil) and 6-methyluracil toward sorbates capable of various intermol. interactions is studied via inverse gas chromatog. in the infinite dilution mode. It is found that the first modifier yields one-dimensional tape supramol. structures as a result of self-assembling, while the second produces two-dimensional network structures. The contributions from intermol. interactions to the Helmholtz energy of adsorption are calculated via the linear decomposition of retention parameters. The dispersion and specific components of the energy of adsorption are determined according to Dong. It is shown that modifying the surface of a porous polymer with thymine increases both specific and dispersive components of the energy of adsorption, while the contributions from different intermol. interactions and the polarity of the surface as a result of modifying with thymine change slightly. Modifying a porous polymer with the same amount of 6-methyluracil results in a notable rise in polarity, due to an increase in the contributions from interactions of induction and orientation. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to thymine methyluracil divinylbenzene styrene copolymer surface polarity, Plastics Manufacture and Processing: Physical Properties and Testing Methods and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia