Day: November 3, 2022

On May 8, 2013, Liu, Yuanyuan; Hao, Zhihui; Wang, Yanling published a patent.Recommanded Product: 23256-42-0 The title of the patent was Soluble powder for treating toxoplasmosis and its preparation method. And the patent contained the following:

This invention provides a soluble powder for treating toxoplasmosis and its preparation method. The title soluble powder comprises sulfamethazine, lactic acid TMP, lincomycin hydrochloride and anhydrous glucose, can be used for treating toxoplasmosis in animals. The formulation can be used after mixing or mixed with water. The soluble powder has low cost and good effect, and is suitable for industrialized production The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 23256-42-0

The Article related to soluble powder toxoplasmosis sulfamethazine lincomycin trimethoprim, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 20, 2017, He, Chun-Yang; Kong, Jingjing; Li, Xuefei; Li, Xiaofei; Yao, Qiuli; Yuan, Fu-Ming published an article.COA of Formula: C5H6N2O2 The title of the article was Visible-Light-Induced Direct Difluoroalkylation of Uracils, Pyridinones, and Coumarins. And the article contained the following:

An efficient and general method for the synthesis of difluoroalkylated uracils, pyridinones, and coumarins through visible-light-induced reaction with com. materials is developed. The strategy proceeds with high efficiency under mild reaction conditions and shows excellent functional group compatibility, even toward bromide and hydroxyl group, thus demonstrates high potent application in a late-stage fluoroalkylation. Moreover, the difluoroalkylated products can be further transformed to a diverse variety of difluoroalkylated heterocycles, including mols. of potential biol. activity. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).COA of Formula: C5H6N2O2

The Article related to photochem fluoroalkylation uracil pyridinone coumarin visible light, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 18, 2018, Zhang, Jiaojiao published a patent.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Veterinary composition for preventing and treating infectious pleuropneumonia and mycoplasma pneumonia in fowls. And the patent contained the following:

The title veterinary composition comprises (by weight parts) tylosin tartrate 8-10, aminopyrine 10-20, trimethoprim lactate 10-20, thenardite 8-12 and oral glucose 8-12. The inventive veterinary composition has good efficacy, no harm, no residue and convenient use, and can be used for preventing and treating infectious pleuropneumonia and mycoplasma pneumonia in fowls. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to veterinary drug fowl infectious pleuropneumonia mycoplasma pneumonia, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 12, 2012, Zhou, Qingfu; Liu, Wenli published a patent.HPLC of Formula: 23256-42-0 The title of the patent was Doxycycline hydrochloride-containing composition for preventing and treating colibacillosis and chronic respiratory disease of poultry and preparation method thereof. And the patent contained the following:

Title composition is composed of doxycycline hydrochloride 10-15, colistin sulfate 10-20, tylosin tartrate 5-15, trimethoprim lactate 5-10, and anhydrous glucose 40-70 weight parts, and is prepared by mixing doxycycline hydrochloride, colistin sulfate and anhydrous glucose 20-30 weight parts for 5-10min, mixing tylosin tartrate, trimethoprim lactate and anhydrous glucose 10-25 weight parts for 5-10min, merging the two mixture, adding residual anhydrous glucose, mixing for 10-15min, and mixing uniformly. The doxycycline hydrochloride-containing composition can be used for preventing and treating colibacillosis and chronic respiratory disease of poultry and has advantages of simple preparation process and good therapeutic effect. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).HPLC of Formula: 23256-42-0

The Article related to doxycycline hydrochloride colibacillosis respiratory disease poultry, Pharmaceuticals: Formulation and Compounding and other aspects.HPLC of Formula: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 5, 2014, there was a patent about bacterial infection.Recommanded Product: 23256-42-0 The title of the patent was Compound veterinary drug preparation for treating enteritis type colibacillosis of poultry. And the patent contained the following:

The invention belongs to compound veterinary drug preparation for treating enteritis type colibacillosis of poultry. The preparation comprises the following components: neomycin sulfate, TMP lactate, and glutamine as main components, and adjuvants, wherein neomycin sulfate 3.25 weight%, TMP lactate 0.81 weight%, glutamine 10 weight%, the adjuvant is glucose, the ratio of adjuvant is 85.94 weight%. The veterinary composition is used for treating enteritis type colibacillosis of poultry. The processing technol. of the composition includes grinding and sieving each component, weighing accurately according to the required proportion, mixing for 25 min, inspecting the semi-finished product quality, packaging, and inspecting the finished product quality to obtain the final product. The invention has obvious curative effect on enteritis type colibacillosis, has low drug resistance, safety, and low toxicity, and has very good popularization and application value. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 23256-42-0

The Article related to neomycin sulfate trimethoprim lactate glutamine powder colibacillosis, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 1, 2007, Wei, Zongsheng; Geng, Qiangbin; Guo, Jianhua published a patent.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Compounded berberine sulfate injection and its preparation method. And the patent contained the following:

The title injection is composed of berberine sulfate 5-30, mequindox 5-35, trimethoprim lactate 1-25 and atropine 0.5-2 weight parts. The method for preparing the injection comprises dissolving berberine sulfate in hot injection water, stirring to obtain solution A, adding mequindox and niacinamide, stirring to obtain solution B, adding trimethoprim lactate and atropine, stirring, adjusting pH to 4-6 with 10% sulfuric acid, adsorbing with 0.1% activated C for 15-20 min and adding injection water to 1000 weight parts. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to antibacterial agent berberine sulfate injection preparation dysentery, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 2, 2014, Liu, Changdou published a patent.Electric Literature of 23256-42-0 The title of the patent was Compound dimetridazole premix for controlling avian enterovirus syndrome. And the patent contained the following:

The invention discloses compound dimetridazole premix for controlling avian enterovirus syndrome, comprising by weight%: dimetridazole 10-30, neomycin sulfate 4-10, decoquinate 2-8, lysozyme 10-30, etamsylate 0.5-5, lactic acid TMP 3-10, and pharmaceutically suitable excipients as balance. The invention adopts new and efficient decoquinate as the anticoccidial drugs, has special effect on intestinal infection dimetridazole and neomycin sulfate, has antibacterial, antiviral, anti-inflammatory pain, intestinal mucosa repair effect of lysozyme, efficient hemostatic drug etamsylate and drug synergistic agent in the compound preparation, and has treatment efficiency on avian enterovirus syndrome. The formula is reasonable, scientific, has simple preparation, wide application, can be used as the preferred drug for prevention and treatment of poultry intestinal toxin syndrome. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Electric Literature of 23256-42-0

The Article related to dimetridazole neomycin sulfate decoquinate avian enterovirus syndrome, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 14, 2021, Pomogaev, Vladimir; Lee, Seunghoon; Shaik, Sason; Filatov, Michael; Choi, Cheol Ho published an article.Electric Literature of 65-71-4 The title of the article was Exploring Dyson’s Orbitals and Their Electron Binding Energies for Conceptualizing Excited States from Response Methodology. And the article contained the following:

The MO concept is a useful tool, which relates the mol. ground-state energy with the energies (and occupations) of the individual orbitals. However, anal. of the excited states from linear response computations is performed in terms of the initial state MOs or some other forms of orbitals, e.g., natural or natural transition orbitals. Because these orbitals lack the resp. energies, they do not allow developing a consistent orbital picture of the excited states. Herein, we argue that Dyson’s orbitals enable description of the response states compatible with the concepts of MO theory. The Dyson orbitals and their energies obtained by mixed-reference spin-flip time-dependent d. functional theory (MRSF-TDDFT) for the response ground state are remarkably similar to the canonical MOs obtained by the usual DFT calculation For excited states, the Dyson orbitals provide a chem. sensible picture of the electronic transitions, thus bridging the chasm between orbital theory and response computations. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Electric Literature of 65-71-4

The Article related to dyson orbital electron binding energy excited state response methodol, General Physical Chemistry: General Theories and other aspects.Electric Literature of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 22, 2015, Wang, Bin; Li, Xuting; Li, Jinliang published a patent.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Composition for treating diarrhea in livestock and poultry and preparation method thereof. And the patent contained the following:

The title composition for treating diarrhea in livestock and poultry comprises norfloxacin lactate, mequindox, trimethoprim lactate, atropine and adjuvant (DMSO, etc.), and can be formulated into granules, tablets, powders, unguents or injections. The invention also provides a preparation method of the composition The inventive composition has quick action, good antimicrobial effect, reduced probability of drug resistance of bacteria, increased antimicrobial sensitivity, simple preparation process, and no drug residue, can prevent infection and secondary infection, and is suitable for treating diarrhea in livestock and poultry. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to veterinary medicine norfloxacin lactate mequindox trimethoprim atropine, Pharmaceuticals: Formulation and Compounding and other aspects.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 13, 2021, Park, Woojin; Lee, Seunghoon; Huix-rotllant, Miquel; Filatov, Michael; Choi, Cheol ho published an article.Category: pyrimidines The title of the article was Impact of the Dynamic Electron Correlation on the Unusually Long Excited-State Lifetime of Thymine. And the article contained the following:

Non-radiative relaxation of the photoexcited thymine in the gas phase shows an unusually long excited-state lifetime, and, over the years, a number of models, i.e., S1-trapping, S2-trapping, and S1&S2-trapping, have been put forward to explain its mechanism. Here, we investigate this mechanism using non-adiabatic mol. dynamics (NAMD) simulations in connection with the recently developed mixed-reference spin-flip time-dependent d. functional theory (MRSF-TDDFT) method. We show that the previously predicted S2-trapping model was due to an artifact caused by an insufficient account of the dynamic electron correlation. The current work supports the S1-trapping mechanism with two lifetimes, τ1 = 30 ± 1 fs and τ2 = 6.1 ± 0.035 ps, quant. consistent with the recent time-resolved experiments Upon excitation to the S2 (ππ*) state, thymine undergoes an ultrafast (ca. 30 fs) S2→S1 internal conversion and resides around the min. on the S1 (nOπ*) surface, slowly decaying to the ground state (ca. 6.1 ps). While the S2→S1 internal conversion is mediated by fast bond length alternation distortion, the subsequent S1→S0 occurs through several conical intersections, involving a slow puckering motion. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Category: pyrimidines

The Article related to impact dynamic electron correlation long excited state lifetime thymine, General Physical Chemistry: General Theories and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia