Day: November 3, 2022

On February 17, 2010, Xu, Kefu published a patent.Computed Properties of 23256-42-0 The title of the patent was Pharmaceutical composition comprising sulfamonomethoxine sodium and olaquindox for treating chicken vibrionic hepatitis and preparation method thereof. And the patent contained the following:

The inventive pharmaceutical composition is prepared from (by weight percentage) sulfamonomethoxine sodium 5-20, olaquindox 2-15, trimethoprim lactate 1-4, glucurolactone 1-10, taurine 2-10 and anhydrous glucose in balance by pulverizing raw materials sep., and mixing for 1 h. The composition is used for treating chicken vibrionic hepatitis. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0

The Article related to veterinary sulfamonomethoxine sodium olaquindox chicken vibrionic hepatitis, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 9, 2014, Liu, Changdou published a patent.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Compound levofloxacin hydrochloride soluble powder for treating respiratory system disease of poultry. And the patent contained the following:

The title compound levofloxacin hydrochloride soluble powder is prepared by mixing the following components: levofloxacin hydrochloride 2-10%, azithromycin 2-10%, Bufonis Venenum 2-6%, licorice extract 10-30%, Kameiding 3-9%, trimethoprim lactate 1-5%, and the balance of pharmaceutically applicable auxiliary materials (sucrose, anhydrous glucose, oral glucose, and/or starch). The invention adopts the latest market medicine, traditional Chinese medicinal extract, novel antiasthmatic medicine and medicine synergist compound into compound preparation, and has antiinflammatory, antibacterial, antiviral, heart tonifying, cough relieving, anti-allergic, poultry disease resistance and immunity increasing, damaged mucosa repairing, secondary infection controlling, and poultry respiratory system disease treating effects. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to levofloxacin hydrochloride soluble powder respiratory system disease poultry, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 1, 2012, Ouyang, Wuqing; Zhou, Ying; Ouyang, Shenyu published a patent.Electric Literature of 23256-42-0 The title of the patent was Rifaximin and trimethoprim lactate compounded nanoemulsion and its preparation method. And the patent contained the following:

The compounded nanoemulsion is composed of surfactant 30-45, cosurfactant 1-10, oil phase 1-16, rifaximin 0.1-5, trimethoprim lactate 0.025-1.25 wt%, and addnl. deionized water. The surfactant is one or more of EL-40, RH-40, Tween-80, and poloxamer 188. The cosurfactant is one or more of anhydrous ethanol, 1,2-propanediol, glycerol, and polyethylene glycol-400. The oil phase is one or more of iso-Pr myristate, glyceryl triacetate, Et oleate, wheat germ oil, Et acetate, and Bu acetate. The preparation method comprises weighing surfactant, cosurfactant, oil phase, rifaximin, trimethoprim lactate and deionized water according to the formula, mixing surfactant with cosurfactant, then adding oil phase, mixing, adding rifaximin, mixing, adding trimethoprim lactate, mixing, and adding deionized water while stirring. This nanoemulsion is suitable for treatment of acute and chronic intestinal tract infection, diarrhea syndrome, etc., and has the characteristics of rapid and persistent effect, high safety and wide market prospect. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Electric Literature of 23256-42-0

The Article related to rifaximin trimethoprim lactate compounded nanoemulsion acute diarrhea composition, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 12, 2012, Zhou, Qingfu; Liu, Wenli published a patent.COA of Formula: C17H24N4O6 The title of the patent was Compound neomycin sulfate composition for treating purulent abscess of pets and preparation method thereof. And the patent contained the following:

The compound neomycin sulfate composition comprises neomycin sulfate 1-3, erythromycin thiocyanate 3-5, trimethoprim lactate 1-2, CTMB 1-3, menthol 3-5, liquid paraffin 50-70, glycerol 7-9, ethylparaben 0.4, essence 1-3, and distilled water 80-113 weight part, and can be processed into cream by conventional method and used for treating purulent abscess of pets, with rational formulation, simple preparation process, and obvious curative effect. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).COA of Formula: C17H24N4O6

The Article related to neomycin sulfate erythromycin thiocyanate trimethoprim lactate pet purulent abscess, Pharmaceuticals: Formulation and Compounding and other aspects.COA of Formula: C17H24N4O6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 27, 2020, there was a patent about pharmaceutical powders, veterinary medicine.Recommanded Product: 23256-42-0 The title of the patent was Method for preparing pharmaceutical soluble powder comprising florfenicol and trimethoprim lactate. And the patent contained the following:

The pharmaceutical soluble powder comprises the following components in parts by weight (g): 9-11 each of florfenicol and anhydrous citric acid, 1.5-2.5 of trimethoprim lactate, and the balance is anhydrous glucose. The preparation method of pharmaceutical soluble powder includes: mol. sieving and weighing the florfenicol, anhydrous citric acid, and trimethoprim lactate, adding all the material into anhydrous glucose, premixing and dispersing for 1 h to obtain the pharmaceutical soluble powder. The present invention discloses a pharmaceutical soluble powder having high efficiency, synergist effect, capable of dissolving the components rapidly, and wide application in veterinary medicines. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 23256-42-0

The Article related to florfenicol anhydrous citric acid trimethoprim lactate pharmaceutical soluble powder, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 23, 2016, Chen, Wei published a patent.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was A compound niacin injection, its preparation method and application for treating human intestinal diseases. And the patent contained the following:

The compound niacin injection is prepared from: main agent 10-20, additive 6-10, and solvent 400-500 weight parts. The main agent is formulated from: nicotinic acid 6-10, berberine sulfate 2-4, or atropine sulfate 6-8, mequindox 3-5, trimethoprim lactate 12-16, and Chinese medicine extracting solution 5-7 weight parts; the additive is formulated from sodium sulfite 2-3, sodium thiosulfate 1-2, and disodium edetate 0.6-1 weight parts. The Chinese medicine extracting solution is prepared by extracting Herba Andrographis 6-8, Herba Dendrobii 4-6, Radix Et Rhizoma Rhei 3-5, and Flos Carthami 6-8 with alc. 40-50 weight parts. The preparation method includes extracting with ethanol, cooling, filtering, dialyzing, supplying solvent, and stirring well. The invented compound niacin injection can be used for treating intestinal tract diseases of human body, it has good effect for inhibiting bacteria such as escherichia coli, staphylococcus, and helicobacter in human intestinal tract, and its curative effect is better than the single preparation of each medicine, and it has reasonable formula, the used raw materials are all the efficient drugs for resisting intestinal bacteria infection, and are safe to use, and have obvious curative effect. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to compound niacin injection preparation chinese medicine extract natural pharmaceutical, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 6, 2019, Li, Xue-Dong; Gao, Yu-Ting; Sun, Ying-Jie; Jin, Xiao-Yang; Wang, Dong; Liu, Li; Cheng, Liang published an article.Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was A NaI/H2O2-Mediated Sulfenylation and Selenylation of Unprotected Uracil and Its Derivatives. And the article contained the following:

An efficient iodide-catalyzed/hydrogen peroxide mediated sulfenylation and selenylation of unprotected uracil and its derivatives with simple thiols and diselenides was established. This coupling tolerates a broad variety of functional groups to provide diverse 5-sulfur/selenium-substituted uracil derivatives in good to excellent yields (up to 93%). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to sodium iodide hydrogen peroxide sulfenylation selenylation unprotected uracil derivative, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 12, 2012, Ouyang, Wuqing; Zhou, Ying; Ouyang, Shenyu published a patent.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Veterinary drug of compound tulathromycin nanoemulsion and preparation method thereof. And the patent contained the following:

The title compound tulathromycin nanoemulsion with particle size of 1-100 nm is prepared from surfactant 30-40, co-surfactant 5-15, oily phase 5-15, tulathromycin 2-5, trimethoprim lactate 0.5-1.25%, and deionized water as balance by conventional method. The surfactant is one or more of EL-40, RH-40, Tween-80, and poloxamer 188. The co-surfactant is one or more of ethanol, 1,2-propanediol, glycerol, and PEG-600. The oily phase is one or more of Et acetate, Bu acetate, iso-Pr myristate, Et oleate, etc. The inventive compound tulathromycin nanoemulsion can obtain good bactericidal/bacteriostatic effect by injection once, has rapid onset of drug action and sustained-release effect, and can avoid first pass effect in liver and reduce the stress response of animals. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to tulathromycin nanoemulsion trimethoprim lactate microfiltration veterinary antimicrobial, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 12, 2008, Wang, Lianmin; Liu, Kefei; Zhang, Xu published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Medicinal composition containing sulfamethoxazole sodium, trimethoprim lactate and maquindox, its formulation and application for preventing and treating duck infectious serositis. And the patent contained the following:

The medical composition is composed of sulfamethoxazole sodium 5-10, trimethoprim lactate 1-2, maquindox 5-10, and pharmaceutically acceptable adjuvant to 100 g. The adjuvant in the medical composition is from sucrose, anhydrous glucose, or oral glucose. The medical composition has the advantages of simple preparation process, definite and stable therapeutic effect, convenient administration and broad spectrum, and may be used to prepare the medical preparations for preventing and treating duck infectious serositis. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to sulfamethoxazole sodium trimethoprim lactate maquindox duck infectious serositis preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 1, 2014, Shao, Pu; Han, Xudong; Wang, Hongwei; Wu, Liming published a patent.Synthetic Route of 23256-42-0 The title of the patent was Veterinary compound norfloxacin nicotinate soluble powder and its preparation method. And the patent contained the following:

The invention discloses a veterinary compound norfloxacin nicotinate soluble powder and its preparation method. The powder, per 100 g, is composed of norfloxacin nicotinate 5-10 g, apramycin sulfate 5-10 g, trimethoprim lactate 2-4 g, and anhydrous glucose in balance. The product can quickly kill intestinal pathogenic microorganisms, so as to effectively control the intestinal bacterial disease in fowls and livestocks and alleviate the problem of bacterial resistance. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Synthetic Route of 23256-42-0

The Article related to norfloxacin apramycin trimethoprim powder intestinal bacterial infection diarrhea veterinary, Pharmaceuticals: Formulation and Compounding and other aspects.Synthetic Route of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia