1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Structures of metabolites isolated from urine of mice treated with the antiviral agent, 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-methyluracil was written by Feinberg, Aaron; Vidal, Pedro M.; Fox, Jack J.; Watanabe, Kyoichi A.; Chun, Moon Woo; Field, F. H.; Bencsath, Aladar; Chait, Brian; Philips, Frederick S.. And the article was included in Drug Metabolism and Disposition on December 31,1984.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:
Mice were treated i.v. with 2-14C-labeled 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-methyluracil (I) [69256-17-3] (501 μCi/365 mg/kg). The 24 h urine collection contained 93% of the radioactivity administered. HPLC anal. of the urine showed 97.2, 1.5, 0.2, and 0.6% of the recovered radioactivity as I and as metabolites A, B, and C, resp. Fractionation of the urine by HPLC yielded 0.98 mg of metabolite A and 0.3 mg of metabolite C. UV, NMR, HPLC, and mass spectral analyses were used to elucidate the structures of metabolites A and C. The spectra for metabolite A were identical to those of the synthesized compound 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-hydroxymethyluracil [94817-51-3]. A postulated structure for metabolite C is given. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3