Day: November 10, 2022

Regioselective synthesis of 2-oxo-2,8-dihydro-[1,2,4]oxadiazolo[2,3-a]pyrimidine-7-carbamates: a new class of antihypertensive peripheral vasodilators was written by Muller, Jean Claude; Ramuz, Henri. And the article was included in Helvetica Chimica Acta in 1982.Formula: C4H5ClN4O The following contents are mentioned in the article:

Oxadiazolopyrimidinecarbamates I (R = Me, Et, Bu, CH2CHMe2, CH2Ph, CH2CH2OMe) were prepared by oxidizing 6-chloro-2,4-pyrimidinediamine to give 3-oxide and reaction with tetrahydropyridine to give II (R1 = H). Treatment of II (R1 = H) with RO2CCl gave II (R1 = CO2R) which cyclized to I on heating. I, especially I (R = Me), have antihypertensive activity. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Formula: C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Formula: C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Nucleosides. XC. Practical synthesis of 2-deoxy-2-fluoro-D-arabinofuranose derivatives was written by Reichman, Uri; Watanabe, Kyoichi A.; Fox, Jack J.. And the article was included in Carbohydrate Research in 1975.Related Products of 56632-83-8 The following contents are mentioned in the article:

A 7-step synthesis of 1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranose was achieved from 1,2:5,6-di-O-isopropylidene-3-O-tosyl-α-D-allofuranose. The crucial steps were the fluorination by use of KF in acetamide and the conversion of 6-O-benzoyl-3-deoxy-3-fluoro-D-glucofuranose into 5-O-benzoyl-2-deoxy-2-fluoro-3-O-formyl-D-arabinofuranose by IO4- oxidation 1-(2-Deoxy-2-fluoro-α-D-arabinofuranosyl)cytosine was also prepared This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Related Products of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Inhibition of microorganisms by pyrimidine nucleosides was written by Mehta, Bipin M.; Hutchison, Dorris J.. And the article was included in Annals of the New York Academy of Sciences in 1975.Electric Literature of C9H12FN3O4 The following contents are mentioned in the article:

A microorganism, Streptococcus faecium variety durans, was sensitive to 1-β-D-arabinofuranosylcytosine (I) [147-94-4] but not methotrexate [59-05-2], 6-mercaptopurine [50-44-2], or 6-thioguanine [154-42-7], and thus is useful in determining I in the presence of these and other pyrimidine nucleosides. The inhibition of this microorganism by 22 pyrimidine nucleosides is given. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Electric Literature of C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Electric Literature of C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Comparison of 2′-fluoroarabinosylpyrimidine nucleosides and 1-β-D-arabinofuranosylcytosine on immunological parameters in vitro was written by Merluzzi, V. J.; Last-Barney, K.; Fox, J. J.. And the article was included in International Journal of Immunopharmacology in 1983.Synthetic Route of C10H13FN2O5 The following contents are mentioned in the article:

Ara C  [147-94-4], 2′-fluoro-5-iodo-arabinofuranosylcytosine (FIAC) [69123-90-6], and 2′-fluoro-5-methylarabinofuranosyluracil (FMAU) [69256-17-3] were analyzed for immunosuppressive activity in vitro. In assay systems quantifying both humoral and cellular immune reactivity of mice, FMAU and FIAC were less immunosuppressive than Ara C by several orders of magnitude. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Synthetic Route of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Synthesis of some 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D-lyxofuranosyl nucleosides was written by Moukha-chafiq, O.; Tiwari, K. N.; Secrist, J. A. III. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2005.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one The following contents are mentioned in the article:

The title compounds I (R1 = uracil, cytosine; R2 = ethynyl, vinyl) were prepared via oxidation by Dess-Martin periodinane and stereoselective Grignard reaction from 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)uracil and 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine. All these new nucleosides were evaluated against seven human tumor cell lines in vitro, and no marked cytotoxicity was noted. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Nucleosides. 110. Synthesis and antiherpes virus activity of some 2′-fluoro-2′-deoxyarabinofuranosylpyrimidine nucleosides was written by Watanabe, Kyoichi A.; Reichman, Uri; Hirota, Kosaku; Lopez, Carlos; Fox, Jack J.. And the article was included in Journal of Medicinal Chemistry in 1979.Electric Literature of C10H13FN2O5 The following contents are mentioned in the article:

The title compounds were prepared by condensation of 3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinosyl bromide [56632-81-6] with the appropriate trimethylsilylated pyrimidines followed by saponification of the protected nucleosides, and evaluated for antiherpes virus activity. 1-(2′-Deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] was the most effective showing 99.5% suppression of viral replication even at concentrations of 0.1 μg/mL. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Electric Literature of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Electric Literature of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Susceptibility of several strains of varicella-zoster virus to 5-substituted derivatives of 2′-deoxyuridine and 1-β-D-arabinofuranosyluracil was written by Machida, Haruhiko; Kuninaka, Akira; Yoshino, Hiroshi. And the article was included in International Congress Series in 1982.Product Details of 69256-17-3 The following contents are mentioned in the article:

In confluent monolayers of human embryonic lung fibroblast cells infected with varicella-zoster virus, 5-bromovinylarabinosyluracil (I) [77181-69-2] and 5-chlorovinylarabinosyluracil  [77181-70-5] were the most potent of the 9 thymidine analogs in inhibiting plaque formation. There was some variability in the susceptibility of different strains of varicella-zoster virus to the thymidine analogs. The susceptibility of varicella-zoster virus to these compounds was different than that of herpes simplex virus type 1 and type 2. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Product Details of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Product Details of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines was written by El-Ghomari, K.; Gorrod, J. W.. And the article was included in European Journal of Drug Metabolism and Pharmacokinetics in 1987.Category: pyrimidines The following contents are mentioned in the article:

Biol. oxidation of 2,4-diamino-6-substituted pyrimidines was studied using hepatic microsomes from various mammalian species. The 3-N-oxides were formed with 6-pipeidino-, 6-diethylamino-, 6-methyl-, and 6-chloro-substituted 2,4-diaminopyrimidines: no evidence of 1-N-oxide formation was obtained. With the 6-hydroxy-, 6-amino-, and unsubstituted 2,4-diaminopyrimidines and melamine, no N-oxidative metabolite was detected. The differences in N-oxide formation is discussed in terms of the effect of substituents on tautomerism and electron distribution. The N-oxygenation was mediated via a cytochrome P 450-dependent system. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Category: pyrimidines).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Category: pyrimidines

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Evaluation of antivirals in preventing herpes simplex virus-induced cataracts in a murine model was written by Schinazi, Raymond F.; Scott, R. Taylor; Gammon, J. Allen; Stulting, R. Doyle; Kuck, John F. R.; Wright, John D.; Nahmias, Andre J.. And the article was included in International Congress Series in 1985.Formula: C10H13FN2O5 The following contents are mentioned in the article:

In mice inoculated intracerebrally with herpes simplex virus type 2, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine (FMAU) [69256-17-3] and FMAC  [78636-53-0] treatment completely inhibited cataract formation; although acyclovir  [59277-89-3], ara-A  [5536-17-4], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-S-iodocytosine (FIAC) [69123-90-6], and other drugs were effective in reducing mortality, they were unable to prevent cataractogenesis. Results on the optimization of virally-induced cataract formation and virol., immunol., and pathol. findings are presented. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Nucleosides. 110. Synthesis and antiherpes virus activity of some 2′-fluoro-2′-deoxyarabinofuranosylpyrimidine nucleosides was written by Watanabe, Kyoichi A.; Reichman, Uri; Hirota, Kosaku; Lopez, Carlos; Fox, Jack J.. And the article was included in Journal of Medicinal Chemistry in 1979.Synthetic Route of C9H12FN3O4 The following contents are mentioned in the article:

The title compounds were prepared by condensation of 3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinosyl bromide [56632-81-6] with the appropriate trimethylsilylated pyrimidines followed by saponification of the protected nucleosides, and evaluated for antiherpes virus activity. 1-(2′-Deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] was the most effective showing 99.5% suppression of viral replication even at concentrations of 0.1 μg/mL. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Synthetic Route of C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8