Day: November 10, 2022

Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia was written by Klein, Richard J.; Friedman-Kien, Alvin E.. And the article was included in Journal of Investigative Dermatology in 1984.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:

The effect of several antiviral drugs on the reactivation of herpes simplex virus type 1 in explant cultures of latently infected mouse trigeminal ganglia was investigated. Phosphonoacetate  [4408-78-0] and phosphonoformate  [4428-95-9] which act directly on the virus-induced DNA polymerase, require a drug concentration of 400 μg/mL for the inhibition of virus reactivation in latently infected ganglia. Arabinosyladenine  [5536-17-4] and arabinosyladenine monophosphate  [29984-33-6], which are phosphorylated to triphosphates by cellular enzymes and inhibit virus synthesis either by blocking the DNA polymerase or by incorporation into viral DNA, require a concentration of only 100 μg/mL for the inhibition of the reactivation process. Drugs that are phosphorylated by the virus-induced thymidine kinase, such as acyclovir  [59277-89-3], arabinosylthymine  [605-23-2], bromovinyldeoxyuridine  [69304-47-8], and three fluorinated pyrimidine nucleosides require the lowest drug concentrations for complete inhibition of virus reactivation in latently infected ganglia explant cultures. These data suggest that the inhibition of virus reactivation is dependent not only on drug concentration, but also on the number of latently infected neurons in the ganglia. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.COA of Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity was written by Ferreira-Bravo, Irani Alves; Cozens, Christopher; Holliger, Philipp; DeStefano, Jeffrey J.. And the article was included in Nucleic Acids Research in 2015.Related Products of 56632-83-8 The following contents are mentioned in the article:

Using a Systematic Evolution of Ligands by Exponential Enrichment (SELEX) protocol capable of selecting xeno-nucleic acid (XNA) aptamers, a 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamer (referred to as FA1) to HIV-1 reverse transcriptase (HIV-1 RT) was selected. FA1 bound HIV-1 RT with K D, apparatus values in the low pM range under different ionic conditions. Comparisons to published HIV-1 RT RNA and DNA aptamers indicated that FA1 bound at least as well as these aptamers. FA1 contained a 20 nucleotide 5′ DNA sequence followed by a 57 nucleotide region of FANA nucleotides. Removal of the fourteen 5′ DNA nucleotides did not affect binding. FA1’s predicted structure was composed of four stems and four loops. All stem nucleotides could be modified to G-C base pairs (14 total changes) with a small effect on binding. Eliminating or altering most loop sequences reduced or abolished tight binding. Overall, results suggested that the structure and the sequence of FA1 were important for binding. FA1 showed strong inhibition of HIV-1 RT in extension assays while no specific binding to avian myeloblastosis or Moloney murine leukemia RTs was detected. A complete DNA version of FA1 showed low binding to HIV-1 RT, emphasizing the unique properties of FANA in HIV-1 RT binding. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Related Products of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Mutagenic potential of anti-herpes agents was written by De Clercq, E.; Cassiman, J. J.. And the article was included in Life Sciences in 1986.SDS of cas: 69256-17-3 The following contents are mentioned in the article:

A number of anti-herpes agents which are either licensed for clin. use (acyclovir  [59277-89-3]) or subject of clin. studies (bromovinyldeoxyuridine  [82768-44-3], fluoroiodoaracytidine  [69123-90-6], dihydroxypropoxymethylguanine  [82410-32-0]) or under preclin. investigation (i.e., fluoroiodoarauridine  [69123-98-4]), fluoromethylarauridine  [69256-17-3], dihydroxybutylguanine  [83470-64-8], bromovinyldeoxycytidine  [84412-83-9], bromovinylarauridine  [77181-69-2], and carbocyclic bromovinyldeoxyuridine  [95463-56-2]) were evaluated for their ability to induce sister chromatid exchange (SCE), an indicator of mutagenesis. SCE was scored on metaphasic chromosomes of human lymphocytes which had been exposed to 5-bromo-2-deoxyuridine and varying concentrations of the test compounds The antiviral assays were based on the inhibition of the cytopathogenicity of herpes simplex virus for human diploid fibroblasts. Most compounds, i.e. acyclovir, bromovinyldeoxyuridine, or carbocyclic bromovinyldeoxyuridine, did either not induce SCE or only so at concentrations far above their min. antiviral concentrations However, fluoroiodoaracytidine and dihydroxypropoxymethylguanine affected the SCE rate at a concentration (≥ 4.5 μg/mL) that is readily achievable in blood following i.v. injection. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3SDS of cas: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.SDS of cas: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Cell differentiation effects of 2′-fluoro-1-β-D-arabinofuranosyl pyrimidines in HL-60 cells was written by Kong, Xiang Bin; Andreeff, Michael; Fanucchi, Michael P.; Fox, Jack J.; Watanabe, Kyoichi A.; Vidal, Pedro; Chou, Ting Chao. And the article was included in Leukemia Research in 1987.Formula: C9H12FN3O4 The following contents are mentioned in the article:

A group of 2′-fluoro and 5-substituted arabinosyl pyrimidines and a group of base-substituted pseudoisocytidine analogs were evaluated for their capacity to induce differentiation in the human promyelocytic leukemia cell line, HL-60. These compounds were compared to 1-β-D-arabinofuranosylcytosine nAra-C) by monitoring: (1) inhibition of cell growth; (2) morphol. maturation; (3) nitroblue tetrazolium (NBT) reduction; (4) expression of a myeloid differentiation antigen, Mo1; and (5) inhibition of colony formation. Exposure of logarithmically growing cells for 5 days to Ara-C, 2′-fluoro-Ara-C (FAC), 2′-fluoro-5-methyl-Ara-C (FMAC) and 2′-fluoro-5-ethyl-Ara-C (FEAC) resulted in cell growth inhibition at 50% inhibitory concentrations of 0.007, 0.11, 1.7 and 18 μM and at cytostatic concentrations of 0.1, 0.5, 5.0 and 50 μM, resp. These compounds induced granulocytic and monocytic maturation, reduction of NBT, increased expression of Mo1 antigen and a decrease or loss of both cell proliferation and colony formation in a semisolid medium. There were few, if any, cell differentiation effects for the uracil nucleosides and pseudoisonucleosides tested. Ara-C was the most cytotoxic of the compounds When comparing absolute numbers of differentiated cells, i.e. percent of pos. cells multiplied by the number of viable cells, FAC, FMAC, and FEAC were superior to Ara-C in inducing differentiation of HL-60 cells. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Formula: C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Different antiviral potencies of BV-araU and related nucleoside analogs against herpes simplex virus type 1 in human cell lines and Vero cells was written by Machida, Haruhiko; Nishitani, Makiko; Suzutani, Tatsuo; Hayashi, Kozaburo. And the article was included in Microbiology and Immunology in 1991.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

Antiviral potencies against herpes simplex virus type 1 (HSV-1) of 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and 10 other nucleoside analogs in human embryonic lung fibroblast (HEL) cells were compared with those in Vero cells. 5-Halogenovinylarabinosyluracils, highly active in HEL cells, were inactive against all 3 laboratory-stocked strains of HSV-1 but exerted moderate antiviral effects on 3 clin. isolates in Vero cells. The reduction in anti-HSV-1 potencies of other representative nucleoside analogs in Vero cells was much less than those of 5-halogenovinylarabinosyluracils. However, significant antiviral potencies of BV-araU against laboratory strains were observed in other human and monkey fibroblast cells including an immortalized cell line. Significant enhancement of antiviral activity of BV-araU against a laboratory strain and a clin. isolate was demonstrated in Vero cells by the addition of 0.1 μM aminopterin or FUdR, an inhibitor of thymidylate synthesis. The potentiated anti-HSV-1 activity in Vero cells was comparable to the potency in HEL cells without the inhibitor. These results suggested that high activity of thymidylate synthesis and a large thymidylate pool size in Vero cells seem to be related to loss of anti-HSV-1 potency of BV-araU. Original tissue type, species, and the immortality may not be responsible for the reduced antiviral activity of BV-araU in Vero cells. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Metabolism of minoxidil, a new hypotensive agent. II. Biotransformation following oral administration to rats, dogs, and monkeys was written by Thomas, Richard C.; Harpootlian, Harry. And the article was included in Journal of Pharmaceutical Sciences in 1975.Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The biotransformation of minoxidil (I) [38304-91-5] was studied in the rat, dog, and monkey and compared to reported results in the human. Each species excreted substantially the same metabolites, but in quite different relative amounts The monkey and the human exhibited similar metabolite profiles, whereas the dog and rat were quant. different from each other and from the monkey and human. The major excretory product for the monkey and human was I glucuronide [56828-40-1]. Substantially smaller amounts of unchanged I, 2,4-diamino-6-(4′-hydroxypiperidino)pyrimidine 3-oxide [56828-37-6], and more polar metabolites also were excreted by these 2 species. The major excretory product in the rat was unchanged I. Almost as much (combined) of the 2 acidic metabolites, 2,4-diamino-6-(4′-carboxy-n-butylamino)pyrimidine [56828-38-7] and its 3-oxide [56828-41-2], also were produced. Smaller amounts of the glucuronide of I, 2,4-diamino-6-(4′-hydroxypiperidino)pyrimidine 3-oxide, its 3′-hydroxy isomer [56828-39-8], and 2,4-diamino-6-piperidinopyrimidine [24867-26-3] also were excreted by the rat. The major metabolite of I excreted by the dog was the 4′-hydroxy metabolite. Smaller amounts of unchanged I and polar metabolites and much smaller amounts of the glucuronide of I, the 3′-hydroxy metabolite, and 2,4-diamino-6-piperidinopyrimidine also were excreted by the dog. Evidence was obtained for a 4′-hydroxy metabolite glucuronide in this species. The major circulatory material in dog plasma was the 4′-hydroxy metabolite, whereas it was the glucuronide of I in monkey plasma. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Inhibition of B virus (Macacine herpesvirus 1) by conventional and experimental antiviral compounds was written by Krug, P. W.; Schinazi, R. F.; Hilliard, J. K.. And the article was included in Antimicrobial Agents and Chemotherapy in 2009.Synthetic Route of C10H13FN2O5 The following contents are mentioned in the article:

B virus infection of humans results in high morbidity and mortality in as many as 80% of identified cases. The main objective of this study was to conduct a comparative anal. of conventional and exptl. antiviral drug susceptibilities of B virus isolates from multiple macaque species and zoonotically infected humans. We used a plaque reduction assay to establish the effective inhibitory doses of acyclovir, ganciclovir, and vidarabine, as well as those of a group of exptl. nucleoside analogs with known anti-herpes simplex virus activity. Four of the exptl. drugs tested were 10- to 100-fold more potent inhibitors of B virus replication than conventional antiviral agents. Drug efficacies were similar for multiple B virus isolates tested, with variations within 2-fold of the median effective concentration (EC50) for each drug, and each EC50 was considerably lower than those for B virus thymidine kinase (TK) mutants. We observed no differences in the viral TK amino acid sequence between B virus isolates from rhesus monkeys and those from human zoonoses. Differences in the TK protein sequence between cynomolgus and pigtail macaque B virus isolates did not affect drug sensitivity except in the case of one compound Taken together, these data suggest that future B virus zoonoses will respond consistently to conventional antiviral treatment. Further, the considerably higher potency of FEAU (2′-fluoro-5-ethyl-Ara-U) than of conventional antiviral drugs argues for its compassionate use in advanced human B virus infections. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Synthetic Route of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Synthetic Route of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Gemcitabine, pyrrologemcitabine, and 2′-fluoro-2′-deoxycytidines: Synthesis, physical properties, and impact of sugar fluorination on silver ion mediated base pairing was written by Guo, Xiurong; Leonard, Peter; Ingale, Sachin A.; Seela, Frank. And the article was included in Chemistry – A European Journal in 2017.SDS of cas: 56632-83-8 The following contents are mentioned in the article:

The stability of silver-mediated “”dC-dC”” base pairs relies not only on the structure of the nucleobase, but is also sensitive to structural modification of the sugar moiety. 2′-Fluorinated 2′-deoxycytidines with fluorine atoms in the arabino (up) and ribo (down) configuration as well as with geminal fluorine substitution (anticancer drug gemcitabine) and the novel fluorescent phenylpyrrolo-gemcitabine (phPyrGem) have been synthesized. All the nucleosides display the recognition face of naturally occurring 2′-deoxycytidine. The nucleosides were converted into phosphoramidites and incorporated into 12-mer oligonucleotides by solid-phase synthesis. The addition of silver ions to DNA duplexes with a fluorine-modified “”dC-dC”” pair near the central position led to significant duplex stabilization. The increase in stability was higher for duplexes with fluorinated sugar residues than for those with an unchanged 2′-deoxyribose moiety. Similar observations were made for “”dC-dT”” pairs and to a minor extent for “”dC-dA”” pairs. The increase in silver ion mediated base-pair stability was reversed by annulation of a pyrrole ring to the cytosine moiety, as shown for 2′-fluorinated phPyrGem in comparison with phenylpyrrolo-dC (phPyrdC). This phenomenon results from stereoelectronic effects induced by fluoro substitution, which are transmitted from the sugar moiety to the silver ion mediated base pairs. The extent of the effect depends on the number of fluorine substituents, their configuration, and the structure of the nucleobase. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8SDS of cas: 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

2,4-Diamino-6-piperidinyl- and 6-piperazinylpyrimidine 3-oxides, new analogs of minoxidil was written by Catto, A.; Lo Verde, G.; Luca, C.; Graziani, G.; Nardi, D.; Casadio, S.. And the article was included in Bollettino Chimico Farmaceutico on January 31,1982.HPLC of Formula: 35139-67-4 The following contents are mentioned in the article:

Title compounds [I; R = Ph, 1-substituted 4-piperidinyl, 1-piperidinyl, CONH2, PhCONH; R1 = OH, H; and RR1 = (CH2)5, SCH2CH2S, OZO (Z = linear or branched alkylene)] and (II; R2 = H, Me, substituted pyrimidinyl, 2-MeOC6H4, 3-ClC6H4, 2-pyridyl) were prepared from 6-chloro-2,4-pyrimidinediamine 3-oxide (III) and III·3-ClC6H4CO2H; I and II exhibited antihypertensive activity. III was treated with 4-phenyl-4-piperidinol to give I (R = Ph, R1 = OH). This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4HPLC of Formula: 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Effects of certain nucleoside analogs on human cytomegalovirus replication in vitro was written by Mar, Engchun; Patel, Pravin C.; Cheng, Yungchi; Fox, Jack J.; Watanabe, Kyoichi A.; Huang, Engshang. And the article was included in Journal of General Virology on January 31,1984.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:

Four nucleoside analogs, 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyluracil (I), -5-iodouracil (II), -5-methylcytosine (III) and -5-iodocytosine (IV), were studied for their effect on human cytomegalovirus (HCMV) replication in vitro. I, II, III, and IV showed antiviral activities for 4 strains of HCMV (Major, Clegg, D550 and Towne) in a plaque reduction assay, with ED50s in the range of 0.1-0.65 μM. At 1 μM I or IV, the synthesis of 5 virus-specific late polypeptides was entirely blocked. Quantification of Towne viral DNA synthesis, using complementary RNA-DNA hybridization with a Towne-specific cRNA probe, demonstrated a complete inhibition of HCMV DNA replication at 1 μM I or IV. After the removal of the inhibitors, however, viral DNA synthesis resumed, and infectious virus reappeared, indicating that the inhibition of HCMV replication by these nucleoside analogs was of a virostatic reversible type. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3