Day: December 1, 2022

Yekeler, Huelya published the artcileProtomeric tautomerisms of N-methylated pyrimidine bases, Synthetic Route of 608-34-4, the publication is Journal of Molecular Structure: THEOCHEM (2005), 713(1-3), 201-206, database is CAplus.

Tautomerisms of N1-Me, N3-Me, and N1, N3-dimethyl derivatives of uracil, 5-fluorouracil and thymine have been examined in the gas phase and in water. Geometry optimizations were carried out at the HF/6-31G**, HF/6-31+G** and B3LYP/6-31+G** levels. Also, single-point MP2/6-31+G** calculations were performed on the HF/6-31+G** optimized geometries. The influence of the solvent was examined from the self-consistent reaction field (SCRF) calculations Analyzing the results, only attachment of fluorine atom at position 5 of N1-Me uracil changes the order of the stabilities of the tautomers.

Journal of Molecular Structure: THEOCHEM published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C21H37BO, Synthetic Route of 608-34-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Wennerbeck, Ingegerd published the artcileCNDO/2 [complete neglect of differential overlap-new version] calculations of rotational barriers in N,N-dimethylamino azines. Line shape study of the barrier in 3-dimethylamino-1,2,4-triazine, Safety of N,N-Dimethylpyrimidin-4-amine, the publication is Journal of Molecular Structure (1974), 22(1), 1-10, database is CAplus.

Barriers to rotation about exocyclic C-N bonds in dimethylamino derivatives of pyridine, pyrimidine, and 1,2,4- and 1,3,5-triazine were studied using CNDO/2 calculations The results were discussed in terms of calculated total and π-charge densities.

Journal of Molecular Structure published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C25H47NO8, Safety of N,N-Dimethylpyrimidin-4-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Wen, Qian published the artcileStudy on the chemical constituents of Crinum latifolium, Product Details of C5H6N2O2, the publication is Yaoxue Shijian Zazhi (2010), 28(3), 225-227, database is CAplus.

The objective of this paper is to investigate the chem. constituents of Crinum latifolium. The chem. constituents of methanol extract of Crinum latifolium were separated by various chromatog. methods. The structures of these chem. constituents were identified by spectral data and physicochem. property. Results show that 15 compounds were resp. identified as: beta-sitosterol (1), daucosterol (2), 5-methyl-2,4(1H,3H)-pyrimidinedione (3), β-purine (4), p-hydroxybenzoic acid (5), Et 4-hydroxybenzoate (6), cinnamyl D-glucopyranoside (7), benzyl D-glucopyranoside (8), adenosine (9), uridine (10), Z-cinnamic acid (11), 5-O-nitrosouridine (12), 3-methyl-1H-pyrimidine-2, 4-dione (13), N-methyl-benzamide (14), and E-cinnamic acid (15). It was concluded that compounds 3-4, 7-10, 12-14 were isolated from Crinum latifolium for the first time.

Yaoxue Shijian Zazhi published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C3H5BN2O2, Product Details of C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Sulkowska, Anna published the artcileInteractions between pyrimidine bases derivatives and serum albumin in the presence of urea, Application of 3-Methylpyrimidine-2,4(1H,3H)-dione, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (1999), 158(1-2), 151-156, database is CAplus.

A study of complex formation between pyrimidine base derivatives and serum albumin should allow us to determine the specificity of interactions of the pyrimidine derivatives with proteins. The role of the secondary and tertiary structure of serum albumin on the binding of the protein is also under investigation. The possible importance of the interactions between aliphatic residues of pyrimidine bases derivatives and serum albumin is discussed with respect to the problem of specific protein-nucleic acid interactions. The results suggest a release of ligands from their binding sites on the denatured polypeptide chain. The importance of hydrophobic interactions of the C5 Me group with hydrophobic grooves of protein in the presence of urea is suggested.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C8H6KNO4S, Application of 3-Methylpyrimidine-2,4(1H,3H)-dione.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Sulkowska, A. published the artcilePhysical aspects of the interaction of pyrimidine and purine bases with proteins, COA of Formula: C5H6N2O2, the publication is Spectroscopy (Amsterdam, Netherlands) (2002), 16(3,4), 379-385, database is CAplus.

The study of complexation of purine and pyrimidine derivatives with two kind of serum albumin using ¹H NMR and spectrofluorescence technique are performed in order to obtain model interactions nucleic acid bases-protein. The order of binding strength is as follows: 5mC > 5mU(T) > 3mU > U for pyrimidines and N6mAde > N6Ado > 1mAde > ATP > Ado > Ade for adenine derivatives The effect of temperature on the hydrophobic interaction between the nitrogen bases and protein has been studied. The destabilization of protein structure causes loss of tertiary structural contacts, indicating that protein conformation is crucial for binding.

Spectroscopy (Amsterdam, Netherlands) published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C6H12Br2, COA of Formula: C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Robba, Max published the artcileCertain derivatives of diazines. I. Synthesis of nitriles of diazines, SDS of cas: 92306-69-9, the publication is Ann. Chim. (Paris) (1960), 351-79, database is CAplus.

All six possible nitriles of pyridazine, pyrimidine, and pyrazine were prepared by dehydration of the corresponding amides with POCl₃. 3-Cyanopyridazine (I) was prepared in poor yield from 3-bromopyridazine (II) and 2-cyanopyrimidine (III) from 2-pyrimidinesulfonic acid. α-Oxoglutaric acid (230 g.) in 390 ml. boiling H₂O treated in 20 min. with 160 g. NaOH, 280 g. (N₂H₄)₂.H₂SO₄ and 980 ml. H₂O, heated 5 min., and cooled gave 181 g. 3-hydroxy-6-carboxy-4,5-dihydropyridazine, m. 196°, which by reaction with POBr₃ gave II. 2,5-Dimethoxy-2,5-dihydrofurfuryl acetate (10.1 g.) and 40 ml. N H₂SO₄ boiled 1 min., cooled rapidly, 5 ml. N₂H₄.H₂O added, the mixture refluxed 20 min., the mixture extracted with 7% MeOH-Et₂O, and the extract distilled yielded isopropylideneacetylhydrazine, b₇ 135-40°, m. 133°, and 28% 3-(hydroxymethyl)pyridazine (IV), b₇ 140-165°, m. 66° (Et₂O-petr. ether). IV was oxidized to 3-carboxypyridazine, which was esterified quant. with CH₂N₂ to 3-carbomethoxypyridazine (V), m. 139° (Et₂O). V (27 g.) in 27 g. MeOH and 70 g. saturated NH₃MeOH gave after several days 90% 3-carbamoylpyridazine (VI), m. 182° (H₂O). VI (3 g.) and 15 ml. POCl₃ treated after 1 hr. with 15 ml. PhMe, refluxed 1 hr., the solvent evacuated, the residue desiccated 24 hrs., dissolved in 30 ml. saturated Na₂CO₃ at 5°, the solution extracted with Et₂O, the extract dried, and concentrated gave 70% I, m. 43-4° (Et₂O). Subsequent nitriles were prepared similarly. 4-Cyanopyridazine (VII) could not be obtained by dehalogenation of 3-chloro-4-cyanopyridazine. 4-Carbomethoxypyridazine, m. 63°, yielded 65% VII, m. 79-80°. 2-Methylpyrimidine (3.6 g.), 26 g. NaOAc, and 55 ml. HOAc treated at 90° with 24.5 g. Br in 10 ml. HOAc, the mixture heated 45 min., refrigerated 1 hr., 90 ml. H₂O added slowly, cooling continued 16 hrs., the product removed, and the addition of H₂O and cooling repeated gave 7.3 g. total 2-tribromomethyl-5-bromopyrimidine (VIII), m. 131° (CHCl₃). AgNO₃ (4.7 g.), 11 ml. H₂O, 3.9 g. VIII, and 29 ml. HOAc heated 1 hr. on a steam bath, filtered, the residue washed with boiling H₂O, the filtrate acidified with 4 ml. HCl, extracted with CHCl₃, and the extract evaporated gave 70% 2-carboxy-5-bromopyrimidine (IX).H₂O, m. 191-2°; free IX m. 231°; methyl ester m. 148-9°, 2-carbamoyl-5-bromopyrimidine (0.75 g.), m. 209°, 60 ml. EtOH, 30 ml. Et₂O, 1.2 ml. 20% Na₂CO₃, and 1 g. Raney Ni stirred 3 hrs. at 50° under 3 kg. II pressure, filtered, the solvents evaporated and the residue extracted with hot CHCl₃ yielded 50% 2-carbamoylpyrimidine, m. 166-7°, after sublimation, converted to III, m. 42°. 2-Chloropyrimidine (3.6 g.), 4.4 g. NaHSO₃, and 20 ml. H₂O heated 1 hr., evaporated, 2 g. KCN ground in, the mixture heated gently at 3 mm. to 260° in 20 min. then to 300° in 20 min., and maintained at 300° until nitrile distillation ceased gave 21% III. 4-Carbomethoxypyrimidine (X), m. 70-1°, was obtained in 47, 52, or 100% yields from the free acid and MeOH-H₂SO₄, MeOH-HCl, or CH₂N₂, resp. X was converted to 4-carbamoylpyrimidine (XI), m. 197°. XI (5.0 g.) stirred 20 hrs. with 30 ml. POCl₃, refluxed 1 hr. at 135-40°, and extracted similarly to I gave 77% 4-cyanopyrimidine (XII), m. 31°. 5-Cyanopyrimidine (XIII), could not be obtained by reductive diazotization of 4-amino-5-cyanopyrimidine. 5-Carboxypyrimidine (XIV) (25 g.) in 200 ml. Et₂O treated at 0° with half of a 1250 ml. Et₂O solution of CH₂N₂ from 75 g. MeN(NO)CONH₂ and 25 g. addnl. XIV added alternately with the rest of the CH₂N₂ gave after 19 hrs. 100% 5-carbomethoxypyrimidine, m. 84°, converted to XIII, m. 85-6°, via 5-carbamoylpyrimidine, m. 214°. Pyrazinamide (3 g.) and 15 ml. POCl₃ stirred 5 hrs., refluxed 40 min., and worked up gave 90% 2-cyanopyrazine (XV), b₇ 87°, m. 20°. Pyrazinoyl chloride (from pyrazinoic acid and SOCl₂, 1.3 hrs. reflux) and p-anisidine in C₆H₆ gave 2-[N-(4-methoxyphenyl)carbamoyl]pyrazine, m. 149-50°. Similarly prepared was 2-[N-(2-naphthyl)carbamoyl]pyrazine, m. 178-9°.

Ann. Chim. (Paris) published new progress about 92306-69-9. 92306-69-9 belongs to pyrimidines, auxiliary class Tetrazoles, name is 4-(1H-1,2,3,4-Tetrazol-5-yl)pyrimidine, and the molecular formula is C5H4N6, SDS of cas: 92306-69-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Robba, Max published the artcileCertain derivatives of diazines. II. Reactions of nitriles of diazines, Related Products of pyrimidines, the publication is Ann. Chim. (Paris) (1960), 414, database is CAplus.

Several thioamides, amidoximes, tetrazoles, imino esters, amidines, and imino ketones containing diazine structures were prepared VII (1 g.) and 14 ml. EtOH saturated at 0° with NH₃ then H₂S, refrigerated 16 hrs., the precipitate removed, dried, and crystallized from EtOH gave 90% 4-thiocarbamoylpyridazine, m. 214-15°. 3-Thiocarbamoylpyridazine, m. 168°, and 2-, 4-, and 5-thiocarbamoylpyrimidine (XVI), m. 225°, 236°, and 170°, resp., were similarly prepared 3-Hydroxy-4-cyanopyridazine (XVII) (1 g.), 10 ml. C₅H₅N, and 0.83 g. Et₃N saturated at 0° with H₂S, the precipitate removed after refrigeration 16 hrs., and a 2nd crop obtained by addition of 15 ml. H₂O gave 89% 3-hydroxy-4-thiocarbamoylpyridazine, m. 305°. XV (0.517 g.) in 0.5 ml. H₂O at 40° treated with 0.34 g. NH₂OH.HCl in 1 ml. H₂O and 1.45 g. Na₂CO₃ in 7 ml. H₂O, the mixture heated 1.5 hrs. at 70-5°, and refrigerated 16 hrs. gave 0.51 g. pyrazine-2-amidoxime, m. 185-6°. Pyridazine-3-amidoxine m. 240°, pyridazine-4-amidoxime m. 209°, 3-hydroxypyridazine-4-amidoxime m. 232°, and 4-pyridine-amidoxime m. 186°. Pyrimidine-2-amidoxime, m. 262°, required 2.3 hrs. heating; 3-hydroxypyridazine-4-amidoxime, m. 305°, was recovered after acidification with HOAc. 5-Thiocarbamoyl pyrimidine (XVI) (0.5 g.), 0.25 g. NH₂OH.HCl, 1 g. Na₂CO₃, 15 ml. EtOH, and 8 ml. H₂O refluxed 8 hrs., the mixture concentrated, and refrigerated 24 hrs. yielded pyrimidine-5-amidoxime, m. 165°. I (0.9 g.), 0.65 g. NaN₃, 1.8 ml. HOAc, and 3 ml. iso-PrOH heated 108 hrs. at 150°, refrigerated 16 hrs., the dried precipitate dissolved in 10 ml. H₂O, and acidified with 10% HCl yielded 1.14 g. 3-(5-tetrazolyl)pyridazine (XVIII), m. 307-8°, after sublimation at 210°/0.01 mm. Similarly prepared were: 4-(5-tetrazolyl)pyridazine, m. 237°; 3-hydroxy-4-(5-tetrazolyl)pyridazine, m. 331°; 2-(5-tetrazolyl)pyrimidine, m. 233°; and 4-(5-tetrazolyl)pyrimidine, m. 266°. XII (1 g.), 0.7 g. NaN₃, 0.57 g. NH₄Cl, and 13 ml. HCONMe₂ stirred 7 hrs. at 125-30°, the solvent evacuated, and the residue worked up as for XVIII yielded 0.872 g. 4-(5-tetrazolyl)pyrimidine, m. 257°. XV (1 g.) in 5 ml. EtOH saturated with HCl at 0°, excess HCl and EtOH evacuated, the residue washed with Et₂O, suspended in 5 ml. EtOH, saturated with NH₃ at -15°, added to 3 ml. saturated NaCl at 0°, extracted with Et₂O, and the extract gave 0.84 g. ethyl pyrazinimidate, m. 49-50°, after sublimation. Similarly obtained were: ethyl pyrimidine-4-carboximidate (XIX), m. 29-30°; methyl pyridazine-4-carboximidate, m. 102-3°; methyl pyridazine-3-carboximidate, m. 79-80°; ethyl pyrimidine-5-carboximidate (XX), m. 87°; and ethyl pyrimidine-2-carboximidate hydrochlorides, m. 64-5°. For XIX, the solution was filtered prior to extraction with Et₂O. XIII (1 g.) treated similarly to XV, the residue washed with Et₂O, and the Et₂O evaporated yielded 0.634 g. XX. The residue on crystallization from EtOH yielded 0.607 g. 5-amidinopyrimidine hydrochloride, m. 213°, also obtained by refluxing 1 hr. 0.545 g. XX, 0.19 g. NH₄Cl, 9 ml. EtOH, and 1 ml. H₂O. For preparation of N-monosubstituted diazinoamidines, 0.0085-0.036 mole nitrile was fused with an equimolar amount of amine at 30-75° (130-150° for XVII), an equimolar amount of AlCl₃ added such that a temperature of 140-220° is reached (170-180° for best yields), the mixture cooled, dissolved in H₂O at 80°, the solution filtered, the filtrate washed with Et₂O, and made alk. with 40% NaOH (Na₂CO₃ for XVII); the amidine was recovered by filtration or extraction with Et₂O or CHCl₃ and purified by crystallization or sublimation. The following 2-(N-monosubstituted-amidino)-pyrazines were prepared: phenyl, m. 104°; o-tolyl, m. 131°, p-chlorophenyl, m. 148°; benzyl, m. 118°; α-naphthyl, m. 128°; β-naphthyl, m. 114°; and p-tolyl, m. 137°. 3-(N-Monosubstituted-amidino)pyridazines: phenyl, m. 121°; p-tolyl, m. 133°; benzyl, m. 92°; p-chlorophenyl, m. 152°; β-naphthyl, m. 137-8°. 4-Analogs: phenyl, m. 160; p-tolyl, m. 167°; p-methoxyphenyl, m. 118°; p-chlorophenyl, m. 149°; β-naphthyl, m. 128°. The following pyridazines: 3-hydroxy-4-(phenylamidino), m. 177°; 3-hydroxy-4-(p-tolylamidino), m. 190°; 3-hydroxy-4-(p-methoxyphenylamidino), m. 178°; 3-hydroxy-4-(p-chlorophenyl)amidino, m. 198°; 3-hydroxy-4-(β-naphthyl)amidino, m. 183°; and 3-hydroxy-4-(2-pyridyl)amidino, m. 197°. 2-(Monosubstituted-amidino)pyrimidines: phenyl, m. 117-18°; o-tolyl, m. 92-3°; p-tolyl, m. 128°; p-chlorophenyl, m. 112°; α-naphthyl, m. 154-5°; β-naphthyl, m. 166°; benzyl, m. 80°. 4-Analogs: phenyl, m. 126°; o-tolyl, m. 104°; p-tolyl, m. 134°; benzyl, m. 72°; α-naphthyl, m. 148°; β-naphthyl, m. 152°; and p-chlorophenyl, m. 135°. VII, PhCH₂NH₂, and AlCl₃ gave, in addition to the amidine, 4-(N-benzylcarbamoyl)pyridazine, m. 80-1°, also prepared from 4-carbomethoxypyridazine. AlCl₃ (0.0095 mole) added in portions to 0.0095 mole each XIII and amine in 25 ml. CS₂, the solution refluxed 3-4 hrs., decomposed in ice-HCl, the product taken up in dilute HCl, and liberated with 20% NaOH at 0-5° gave 10-38% yields of the following pyrimidines: 5-(N-phenylamidino), m. 172°; 5-(p-tolylamidino), m. 190°; 5-(p-methoxyphenylamidino), m. 178-9°; 5-(2-pyridylamidino), m. 151°; and 5-(2-thiazolylamidino), m. 162-3°. MeMgI (0.0283 mole) in 20 ml. Et₂O added to 0.0905 mole I in 30 ml. Et₂O, the mixture stirred 3 hrs., 15 g. ice and 3 g. NH₄Cl added after 16 hrs., the Et₂O layer separated, the aqueous layer extracted with Et₂O, the Et₂O extracts washed with NaCl, dried, and concentrated gave 0.64 g. oil, which chromatographed (Al₂O₃) gave 3-acetylpyridazine (XXI), m. 87-8°, and VI. The aqueous phase stirred 1 hr. with 20% HCl below 5°, neutralized with 40% NaOH, and the product taken up in Et₂O gave addnl. XXI in 27% total yield. 4-Acetylpyrimidine, m. 67°, was obtained similarly. VII (1 g.) in 50 ml. Et₂O and 5 ml. C₆H₆ treated with 0.0283 mole MeMgI and the mixture treated as in the preparation of XXI, yielded 71% 4-(iminoacetyl)pyridazine, m. 78-9°. 5-(Iminoacetyl)pyrimidine, m. 180-1°, was prepared similarly. Et₂NH (0.0042 mole) in 5 ml. Et₂O added to 0.0142 mole EtMgBr in 12 ml. Et₂O, the solution refluxed 20 min., cooled, 1 g. III in 5 ml. Et₂O and 2 ml. C₆H₆ added, the mixture refluxed 2 hrs., and worked up as for XXI then chromatographed gave 0.208 g. 2-(diethylcarbamoyl)pyrimidine, m. 35-6°. XII gave 4-(diethylcarbamoyl)pyrimidine, m. 36-7°, and XI.

Ann. Chim. (Paris) published new progress about 92306-69-9. 92306-69-9 belongs to pyrimidines, auxiliary class Tetrazoles, name is 4-(1H-1,2,3,4-Tetrazol-5-yl)pyrimidine, and the molecular formula is C5H4N6, Related Products of pyrimidines.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Poznanski, Jaroslaw published the artcilePartial molar volume as an important thermodynamic parameter. Application for uracil methyl derivatives, Product Details of C5H6N2O2, the publication is Journal of Molecular Liquids (2005), 121(1), 15-20, database is CAplus.

Quantum mech. calculations of the solvation were performed for all 16 possible methylated uracil derivatives using the Polarizable Continuum Model (PCM) approach. The obtained results were found to reproduce the exptl. data of hydration enthalpies. The decomposition of QM-derived Gibbs energy enabled us to correlate the solute-solvent Gibbs energy interaction with the difference between partial molar volume and mol. volume In aqueous medium, the change of the “effective” solute volume upon dissolution costs 1.8 kJ mol^-1 per every 1 cm³ mol^-1 of the difference between solute partial molar volume and mol. volume

Journal of Molecular Liquids published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Product Details of C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Kobayashi, Shigeru published the artcileSynthesis of pyrimidines and condensed pyrimidines, COA of Formula: C6H9N3, the publication is Bulletin of the Chemical Society of Japan (1973), 46(9), 2835-9, database is CAplus.

A new one-step synthesis of pyrimidines, e.g. I (R = alkyl) and condensed pyrimidines, e.g., II (n = 2-4) by heating carboxamides or cyclic lactams with formamide in the presence of POCl3 in a sealed tube is described.

Bulletin of the Chemical Society of Japan published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C6H9N3, COA of Formula: C6H9N3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Jovanovic, Misa V. published the artcileSyntheses of some pyrimidine N-oxides, Synthetic Route of 31401-45-3, the publication is Canadian Journal of Chemistry (1984), 62(6), 1176-80, database is CAplus.

Various monosubstituted pyrimidines and methylpyrimidines were N-oxidized with a number of different peracids. In general, they are more susceptible to side reactions accompanying N-oxidation than other π-deficient diazines and triazines. Unsym. pyrimidines, which can potentially yield 2 isomeric products, were N-oxidized preferentially at the site para to strong electron-donating substituents. Weaker ring-activating groups, such as Me, are mainly ortho-directing and only aid in the N-oxidation of pyrimidine nuclei having ortho/para-directing substituents.

Canadian Journal of Chemistry published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C6H9N3, Synthetic Route of 31401-45-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia