Month: December 2022

Pyrimidine reactions. XXII. Relative reactivities of corresponding chloro-, bromo-, and iodopyrimidines in aminolysis was written by Brown, Desmond J.;Arantz, B. W.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1971.SDS of cas: 16879-39-3 This article mentions the following:

Times of half completion of aminolysis of 2-halo- (I), 5-bromo-2-halo- (II), 2-halo-4,6-dimethyl- (III), and 4-halo-2,6-dimethylpyrimidines (IV) by isopentylamine (V) and 1,4-dimethylpentylamine (VI) are reported. For aminolysis of I with V the relative reactivities were Br > Cl, and with VI, Br ≫ Cl; for aminolysis of II with VI, Br > Cl; for aminolysis of III with V, Br > Cl ≫ I, and with IV, Br ∼ I ≫ Cl; for aminolysis of IV with V or VI Br ≫ I > Cl, but the greatest difference in rate was only about 3-fold. Eight (isopentylamino)- or (1,4-dimethylpentyl)aminopyrimidines derived from these reactions were characterized, and the preparations of 2,5-dibromo-, 1,2-dihydro-5-iodo-2-oxo-, 2-chloro-5-iodo-, and 4-bromo-2,6-dimethylpyrimidine were described. Ionization constants and uv spectra for solutions in cyclohexane are given. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3SDS of cas: 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.SDS of cas: 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Health risks associated with sulfonamide and quinolone residues in cultured Chinese mitten crab (Eriocheir sinensis) in China was written by Fang, Longxiang;Huang, Zhuyu;Fan, Limin;Hu, Gengdong;Qiu, Liping;Song, Chao;Chen, Jiazhang. And the article was included in Marine Pollution Bulletin in 2021.Product Details of 1220-83-3 This article mentions the following:

The occurrence of 27 antibiotics (18 sulfonamides and 9 quinolones) in 92 samples of cultured Chinese mitten crab (Eriocheir sinensis) from three provinces (Anhui, Jiangsu and Liaoning) was investigated. These 21 antibiotics were detected at least once in crabs from these provinces with detection frequencies of 3.70-90.91%. Sulfonamides were detected in 53.7% of the samples at concentrations of 0.1-10μg/kg in Jiangsu, while quinolones were detected with 90.9% of samples containing concentrations of 1-100μg/kg in Liaoning province. Enroflxacin, ciprofloxacin, sulfaquinoxaline, sulfameter, sulfadoxine, and sulfamethoxazole were the mainly used antibiotics and enroflxacin were present at a high concentration (>100μg/kg). Dietary assessments showed that residual antibiotics in crabs from China were far below the maximum residue limit (MRL) of total sulfonamides and quinolones, and there was almost no risk associated with crab consumption. These results will provide meaningful indications for the safety of crab consumption. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Product Details of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Product Details of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Identification and quantification of multi-class veterinary drugs and their metabolites in beef using LC-MS/MS was written by Jung, Young Sung;Kim, Dan-Bi;Nam, Tae Gyu;Seo, Dongwon;Yoo, Miyoung. And the article was included in Food Chemistry in 2022.Recommanded Product: 1220-83-3 This article mentions the following:

The practice of abusing antibiotics to improve livestock growth poses a threat to food safety. To prevent and regulate this, accurate monitoring of residual veterinary drugs (VDs) is required. A method based on QuEChERS with dispersive solid-phase extraction for the determination of multi-class VDs was investigated using selected product ions under optimized multiple reaction monitoring conditions. During the clean-up procedure, chitosan, octadecyl silica, primary-secondary amine, and enhanced matrix removal (EMR)-lipid were evaluated for simultaneous anal. of multi-class VDs in beef matrix. The EMR sorbent was most advantageous (113/115) compared to others, and showed a satisfactory recovery range (70.7-117.9%) except cefquinome (67.3%) and cefalonium (69.8%). This methodol. can be used to detect oxolinic acid and ractopamine (27.4% and 88.0% of maximum residue limit, resp.) in real beef samples. We thus study propose a simple and fast anal. method for multi-class VDs for the future health of humans and animals. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Recommanded Product: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Molecularly imprinted electrospun nanofibre membrane assisted stir bar sorptive extraction for trace analysis of sulfonamides from animal feeds was written by Cui, Yahan;Jiang, Liyan;Li, Huiyu;Meng, Di;Chen, Yanhua;Ding, Lan;Xu, Yang. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2021.Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The widespread addition of sulfa antibiotics in feeds has long been an environment safety issue. Therefore, it is quite meaningful to constantly propose better solutions for determining the sulfa antibiotics in the environment. Herein, molecularly imprinted electrospun nanofibre membrane (MIM) assisted stir bar sorptive extraction method for the determination sulfonamides (SAs) in feed was developed. In this study, molecularly imprinted polymers (MIPs) were firstly prepared via emulsion polymerization using sulfamonomethoxine as template. Then, the morphol.-controllable MIM was obtained with MIPs-doping electro-spinning solution using electro-spinning technique. Next, MIM are coated on the magnetic stir bar by heat-sealing. Finally, MIM coated stir bar was used for selective enrichment of SAs. The obtained MIM exhibited excellent class selectivity towards SAs (the selectivity factor β is 2.3-2.7). The MIM coated stir bar can be directly applied to extract SAs from feed samples. Under the optimum extraction conditions, the detection limit of the method could reach 1.5-3.4 ng/g. And satisfactory recoveries ranging from 80 ± 6% to 89 ± 7% were achieved under all three spiked levels for determination of four SAs in five different feed samples. The present work not only offers insights to develop magnetic stir bar using imprinted membrane, but also provides a new method for SAs extraction In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Assembly of Silver(I) Two- and Three-Dimensional Coordination Networks with Complementary Tridentate Heteroaryl Ethynide Ligands was written by Zhao, Liang;Mak, Thomas C. W.. And the article was included in Inorganic Chemistry in 2009.Recommanded Product: 2-Ethynylpyrimidine This article mentions the following:

Three pairs of complementary N heteroaryl ligands [2,6-(CC)₂-py and 2-CC-pym; 2,5-(CC)₂-py and 2-CC-pyz; 3,5-(CC)₂-py and 5-CC-pym (py = pyridine, pyz = pyrazine, pym = pyrimidine)], wherein a ring N atom in one is interchanged with a C atom bearing an ethynyl substituent in the other, were used to generate seven Ag(I) complexes (1–7), in which Ag infinite chains and two-dimensional coordination networks bridged by heteroaryl ethynide ligands were obtained as pre-programmed. The relative positions and bonding preference between the ethynide group and ring N atom act as controlling factors to produce various structural building units for the formation of multidimensional coordination networks. The fusion of CC⊃Ag_n (n = 3, 4) building units yields multinuclear Ag aggregates in 1–6 whose nuclearities range from seven to twelve. The crystal structure of 7 displays a honeycomb layer composed of Ag₄ baskets alternately linked by pyrimidinyl-5-ethynide ligands. Complex 1 features an infinite chain composed of an alternate arrangement of twist-boat H₂O hexamers and bridging Ag atoms. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Recommanded Product: 2-Ethynylpyrimidine).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Recommanded Product: 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Time-Efficient Synthesis of Pyrido[2,3-d]pyrimidinones via α-Oxoketenes was written by Castillo, Juan-Carlos;Quiroga, Jairo;Rodriguez, Jean;Coquerel, Yoann. And the article was included in European Journal of Organic Chemistry in 2016.Product Details of 54030-56-7 This article mentions the following:

α-Oxoketene reactive intermediates generated in situ by microwave-assisted Wolff rearrangement of 2-diazo-1,3-dicarbonyl compounds have been found to react with 6-aminopyrimidine derivatives as 1,3-C,N-bis-nucleophiles to yield pyrido[2,3-d]pyrimidinones and related compounds amenable to further functionalization. Thus, e.g., Friedel-Crafts/imination cascade reaction of 3-diazoacetylacetone with 6-amino-1,3-dimethyluracil under microwave radiation afforded pyridopyrimidinone I (98%). In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Product Details of 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Product Details of 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A novel calibration strategy based on isotopic distribution for high-throughput quantitative analysis of pesticides and veterinary drugs using LC-HRMS was written by Sun, Feifei;Tan, Haiguang;Abdallah, Mohamed F.;Li, Yanshen;Zhou, Jinhui;Li, Yi;Yang, Shupeng. And the article was included in Journal of Hazardous Materials in 2022.Related Products of 1220-83-3 This article mentions the following:

Preparation of calibration curves is a critical step for large-scale quantification. However, this procedure is time-consuming, labor intensive. Herein, a novel isotopologue multipoint calibration (IMC) strategy, was proposed and demonstrated for the simultaneous quantitation of 120 pesticides and 83 veterinary drugs in surface water samples using Liquid Chromatog.-High Resolution Mass Spectrometry (LC-HRMS). In this strategy, the natural isotopic distribution was used to generate external calibration curves, eliminating the need of analyst’s adjustment and many sets of chem. standard solutions required in external calibration curves. Addnl., this strategy was comprehensively validated, and the results indicated this strategy had better performance in both accuracy and precision, fully meeting the requirements for the quant. anal. Interestingly, for the samples with high concentration beyond the upper limit of quantitation, the IMC strategy could avoid samples dilution by monitoring the less abundant isotopic channels. Furthermore, the IMC method was successfully applied in the surface water samples collected from Anhui province, China. Among which, sulfamethoxazole and imidacoprid were the main contributors. In conclusion, we present a promising LC-HRMS strategy for the accurate quantitation of small mols., which has a potential application in food and environmental anal. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Related Products of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Related Products of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Impacts of biochars on bacterial community shifts and biodegradation of antibiotics in an agricultural soil during short-term incubation was written by Zhang, Guixiang;Zhao, Zhihua;Yin, Xin-An;Zhu, Yuen. And the article was included in Science of the Total Environment in 2021.Application of 1220-83-3 This article mentions the following:

This study investigated the effects of applying different biochars to soil on shifts in the bacterial community, the biodegradation of antibiotics, and their relationships. In total, nine biochars were applied to agricultural soil contaminated with 16 antibiotics. Clustering anal. showed that the responses of bacteria at the genus level to biochars were highly dependent on the biochar feedstock rather than the pyrolysis temperature Among the antibiotics tested in the study, the biodegradation percentage was lower for tetracyclines (TCs, 6-14%) than sulfonamides (SAs, 8-26%) and quinolones (QLs, 8-24%). For specific individual antibiotics from the same class with similar structures, the high adsorption affinity of soil particles for antibiotics due to hydrophobic interactions (logK_ow) and electrostatic interactions (pK_a) resulted in low biodegradation percentages for antibiotics in the soil. The biodegradation of TCs was affected more by the biochar type (effect size: -10% to 42%) than those of QLs (-26% to 14%) and SAs (-24% to 22%). According to the relationships determined between the bacterial taxonomic composition and biodegradation of antibiotics, Steroidobacter from the phylum Proteobacteria has significant pos. correlations with the biodegradation of all SAs (p < 0.01), thereby indicating that Steroidobacter had a high capacity for biodegrading SAs. Significant pos. correlations were also detected (p < 0.05) between specific genera (Iamia, Parviterribacter, and Gaiella) from the phylum Actinobacteria and the biodegradation of SAs. No significant pos. correlations were found between bacterial genera and the biodegradation percentages for QLs and TCs, possibly due to the specific microorganisms involved in these biodegradation processes. The results in this study provide insights into the biodegradation mechanisms of antibiotics in soil and they may facilitate the development of strategies for the bioremediation of antibiotic-contaminated soil. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Design and synthesis of 1,2,3-triazole incorporated pyrimidine-benzoxazole derivatives as anticancer agents was written by Sudhakar, D. G. S.;Rao, A. Srinivasa;Reddy, Ch. Venkata Ramana;Somaiah, Nalla. And the article was included in Chemical Data Collections in 2022.COA of Formula: C6H4N2 This article mentions the following:

A new library of 1,2,3-triazole linked pyrimidine-benzoxazole derivatives I [Ar = pyridin-4-yl, 4-ClC₆H₄, pyrimidin-2-yl, etc.] was synthesized and characterized. Further, the preliminary anticancer activities of compounds I were tested on four human cancer cell lines such as prostate cancer (PC3 and DU-145), lung cancer (A549) and breast cancer (MCF-7) by using of MTT method. These activities were compared with clin. drug candidate etoposide. Among the screened compounds, five compounds I [R = pyridin-4-yl, pyrimidin-2-yl, 3,5-(Me)₂C₆H₃, 3,5-(OMe)₂C₆H₃, 3,4,5-(OMe)₃C₆H₂] exhibited considerable activities on four cell lines. In which one compound I [R = pyrimidin-2-yl] showed most promising activity among the synthesized compounds In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0COA of Formula: C6H4N2).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C6H4N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of 2-substituted-Pyrimidine-based porous aromatic frameworks via oxygen involved biginelli multicomponent polymerization: toward high performance Li-S batteries was written by Ji, H.;Yan, G.;Wang, H.;Feng, Y.;Zhang, X.;Geng, D.;Shi, J.;Liu, G.;Qu, X.. And the article was included in Materials Today Chemistry in 2022.Name: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Facile, general methods for the preparation of functionalized porous aromatic frameworks (PAFs) are necessary. Herein, we describe a new method for the one-step synthesis of functionalized pyrimidine-based PAFs via oxygen involved Biginelli multicomponent polymerization As first application instance, we constructed a 2-amino-pyrimidine-based PAF (BPAF-1), and followed by employed it as a sulfur host material for lithium-sulfur batteries. Attributed to its 2-amino-pyrimidine structural superiorities, the BPAF-1/S composites demonstrate excellent electrochem. performance as cathode in lithium-sulfur batteries, such as good cyclability with a high capacity retention of 78.1% after 500 cycles and high rate capability up to 5C. Besides, it is convenient to bring various 2-substituted functional groups such as -OH, -SH, Me, and Ph functional groups to pyrimidine-based PAFs under similar conditions, which provided its wide applicability. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Name: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Name: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia