Day: January 5, 2023

Development of a modified quick, easy, cheap, effective, rugged, and safe method based on melamine sponge for multi-residue analysis of veterinary drugs in milks by ultra-performance liquid chromatography tandem mass spectrometry was written by Ji, Baocheng;Zhao, Wenhao;Xu, Xu;Han, Yu;Jie, Mingsha;Xu, Gaigai;Bai, Yanhong. And the article was included in Journal of Chromatography A in 2021.Formula: C11H12N4O3S This article mentions the following:

The purpose of this study was to develop a modified QuEChERS method based on melamine sponge for rapid determination of multi-class veterinary drugs in milks by UPLC-MS/MS. Through simple infiltration and extrusion, fast and convenient matrix purification could be achieved within several seconds, and there was no need of extra phase separation operations. Good linearity with correlation coefficient (R2) ≥0.999 was obtained for all drugs in the range of 2∼500μg·kg-1. The obtained matrix effects were within ±20% for all monitored drugs. The recoveries of all monitored drugs ranged from 60.7% to 116.0% at three spiked levels (50, 100, and 200μg·kg-1), with relative standard deviations less than 7.4%. Comparatively low LODs and LOQs were obtained in the ranges of 0.1∼3.8μg·kg-1 and 0.2∼6.3μg·kg-1, resp. Compared with conventional purification adsorbents, melamine sponge yielded an equal or higher purification performance with matrix removal rate as high as 52.5% and acceptable recoveries in range of 60%-120% for all monitored drugs. The satisfactory results have demonstrated the good potential of melamine sponge in matrix purification for rapid determination of multiclass residues in food safety. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Formula: C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Shock sensitivity of a vinamidinium bis-perchlorate reagent and demonstration of a lower energy alternative was written by Ragan, John A.;McDermott, Ruth E.;Jones, Brian P.;am Ende, David J.;Clifford, Pamela J.;McHardy, Stanton J.;Heck, Steven D.;Liras, Spiros;Segelstein, Barb E.. And the article was included in Synlett in 2000.Product Details of 90905-32-1 This article mentions the following:

“Vinamidinium” bisperchlorate salt [2-dimethylaminomethylene-1,3-bis(dimethylimmonio)-propane bis-perchlorate] (I) possesses remarkably high thermal energy as well as significant shock sensitivity. Because a reported method for preparation of 2,5-disubstituted pyrimidines with I was of interest, the corresponding bis(tetrafluoroborate) salt was equally effective in this transformation. However, use of the bis(tetrafluoroborate) salt was safer with respect to shock sensitivity and energy content, compared to I. I has use as a synthetic reagent in pyrimidine annulations. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Product Details of 90905-32-1).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Product Details of 90905-32-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of some derivatives of 1-(2′,3′,4′,6′-tetra-O-acetyl-β-D-glucopyranosyl)-3-(4”,6”-diarylpyrimidine-2”-yl)-thioureas was written by Nguyen, Dinh Thanh;Nguyen, Thi Thanh Mai. And the article was included in Tap Chi Hoa Hoc in 2008.Category: pyrimidines This article mentions the following:

Thioureas I (R¹ = H, 4-Cl, 3-Cl, 4-Br, 4-OMe; R² = Ac) were synthesized from the corresponding glucopyranosyl isothiocyanate and 2-amino-4,6-diarylpyrimidines using two different synthetic methods. Hydrolysis of I (R² = Ac) afforded the corresponding deacetylated thioureas I (R² = H). In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Category: pyrimidines).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Equilibrium carbon acidity of arylacetylenes in dimethyl sulfoxide was written by Terekhova, M. I.;Petrov, E. S.;Vasilevskii, S. F.;Ivanov, V. F.;Shvartsberg, M. S.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1984.Quality Control of 2-Ethynylpyrimidine This article mentions the following:

The pK values of 4-RC₆H₄CCH (R = Me₂N, MeO, Me, H, F, Br, Cl), 2- and 1-naphthylethyne, 3- and 4-pyridylethyne, and 2-pyrimidinylethyne in Me₂SO decreased in order from 30.8 to 25.8. LFER between pK and σ or σ⁰ constants were obtained. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Quality Control of 2-Ethynylpyrimidine).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Quality Control of 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependent RNA polymerase: 2-Aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives was written by Rawal, Ravindra K.;Katti, S. B.;Kaushik-Basu, Neerja;Arora, Payal;Pan, Zhenhua. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Quality Control of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Hepatitis C virus (HCV) NS5B RNA polymerase is crucial for replicating the HCV RNA genome and is an attractive target for developing anti-HCV drugs. A novel series of 2,3-diaryl-1,3-thiazolidin-4-one derivatives were evaluated for their ability to inhibit HCV NS5B. Several compounds emerged as more potent, displaying over 95% inhibition of NS5B RNA polymerase activity in vitro. The two most active compounds exhibited an IC₅₀ of 31.9 μM and 32.2 μM, resp., against HCV NS5B. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Quality Control of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Simultaneous preconcentration and determination of sulfonamide antibiotics in milk and yoghurt by dynamic pH junction focusing coupled with capillary electrophoresis was written by Semail, Nadhiratul-Farihin;Abdul Keyon, Aemi Syazwani;Saad, Bahruddin;Kamaruzaman, Sazlinda;Mohamad Zain, Nur Nadhirah;Lim, Vuanghao;Miskam, Mazidatulakmam;Wan Abdullah, Wan Nazwanie;Yahaya, Noorfatimah;Chen, David D. Y.. And the article was included in Talanta in 2022.Formula: C11H12N4O3S This article mentions the following:

A dynamic pH junction was used in capillary electrophoresis (CE-DAD) to online preconc., sep., and determine trace amounts of sulfonamide antibiotics (SAs) in milk and yoghurt samples in this study. A sample matrix with 0.15% acetic acid and 10% methanol (MeOH) at a pH of 4.0, and a background electrolyte (BGE) that contained 35 mM sodium citrate with 10% MeOH at a pH of 8.5, and an acidic barrage of 0.4% acetic acid with 10% MeOH at a pH of 2.5 were utilized to achieve a stacking effect for SAs through a dynamic pH junction. Under optimized conditions, the proposed preconcentration method showed good linearity (30-500 ng/mL, r2 ≥ 0.9940), low limits of detection (LODs) of 4.1-6.3 ng/mL, and acceptable analytes recovery (81.2-106.9%) with relative standard deviations (RSDs) within 5.3-13.7 (n = 9). The limits of quantification (LOQs) were below the maximum residue limit approved by the European Union (EU) in this type of matrixes. Sensitivity enhancement factors of up to 129 were reached with the optimized dynamic pH junction using CE with a diode array detector (DAD). The method was used to determine SAs in fresh milk, low-fat milk, full-cream milk, and yoghurt samples. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Formula: C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Formula: C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Removal of refractory organic pollutants by cobalt-doped graphene aerogel activated peroxymonosulfate oxidation was written by Li, Yukun;Chao, Cong;Zhang, Dan;Chen, Qishi;Sun, Junhong. And the article was included in Materials Science in Semiconductor Processing in 2022.Synthetic Route of C11H12N4O3S This article mentions the following:

Recently, peroxymonosulfate-based advanced oxidation process has been widely applied in the removal of refractory organic pollutants. In the present study, cobalt-doped graphene aerogel (Co-GA) composites have been fabricated as a promising activator for peroxymonosulfate (PMS) via in-situ synthesis successfully. The phys.-chem. properties of composite catalysts were carefully characterized and the activation performance was evaluated by the degradation of sulfamonomethoxine (SMM), ciprofloxacin (CIP), sulfanilamide (SN) and rhodamine B (RhB) aqueous solution, resp. The results showed that Co-GA could effectively degrade refractory organics and keep macroscopic morphol. intact under the reaction conditions of 15 mg/L simulated wastewater, 0.3 g/L PMS, 0.2 g/L Co-GA. Furthermore, the effect of reaction parameters on SMM degradation was investigated. Co-GA/PMS system exhibited consistent performance over a wide pH range (3-11). The degradation mechanism of SMM is free radical oxidation dominated by sulfate radical (SO^•-₄) combined with non-radical reaction initiated by GA. Benefiting from its flexibility and recyclability, the as-prepared Co-GA is suitable for practical wastewater purification In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors was written by Xu, Li;Hartz, Richard A.;Beno, Brett R.;Ghosh, Kaushik;Shukla, Jinal K.;Kumar, Amit;Patel, Dipal;Kalidindi, Narasimharaju;Lemos, Nadine;Gautam, Shashyendra Singh;Kumar, Anoop;Ellsworth, Bruce A.;Shah, Devang;Sale, Harinath;Cheng, Dong;Regueiro-Ren, Alicia. And the article was included in Journal of Medicinal Chemistry in 2021.COA of Formula: C6H4N2 This article mentions the following:

Galectin-3 is a member of a family of β-galactoside-binding proteins. A substantial body of literature reports that galectin-3 plays important roles in cancer, inflammation, and fibrosis. Small-mol. galectin-3 inhibitors, which are generally lactose or galactose-based derivatives, have the potential to be valuable disease-modifying agents. In our efforts to identify novel galectin-3 disaccharide mimics to improve drug-like properties, we found that one of the monosaccharide subunits can be replaced with a suitably functionalized tetrahydropyran ring. Optimization of the structure-activity relationships around the tetrahydropyran-based scaffold led to the discovery of potent galectin-3 inhibitors. Three compounds (identified within) were selected for further in vivo evaluation. The synthesis, structure-activity relationships, and in vivo evaluation of novel tetrahydropyran-based galectin-3 inhibitors are described. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0COA of Formula: C6H4N2).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C6H4N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A regiospecific three-component one-step cyclocondensation to 6-cyano-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones using microwaves under solvent-free conditions was written by Quiroga, J.;Cisneros, C.;Insuasty, B.;Abonia, R.;Nogueras, M.;Sanchez, A.. And the article was included in Tetrahedron Letters in 2001.Product Details of 54030-56-7 This article mentions the following:

In a solvent-free system, regiospecific three-component one-step cyclocondensation to dihydropyrido[2,3-d]pyrimidin-4(3H)-ones starting from readily available aminopyrimidin-4(3H)-ones, benzoylacetonitrile and benzaldehydes by microwave radiation was carried out. This rapid method produces pure products in high yields (70-75%). In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Product Details of 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Product Details of 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Nickel-Catalyzed Synthesis of Pyrimidines via Dehydrogenative Functionalization of Alcohols was written by Chakraborty, Gargi;Sikari, Rina;Mondal, Rakesh;Mandal, Sutanuva;Paul, Nanda D.. And the article was included in Asian Journal of Organic Chemistry in 2020.Recommanded Product: 40230-24-8 This article mentions the following:

Herein, a comparative study of nickel-catalyzed syntheses of pyrimidines via dehydrogenative multi-component coupling of alcs. and amidines using two different classes of nickel catalysts differing with respect to their mode of action during catalysis is reported. The catalysts are either two tetracoordinate Ni(II)-complexes containing two apparently redox-inactive tetraaza macrocyclic ligands or square planar Ni(II)-complexes featuring redox-active diiminosemiquinonato type scaffolds. Tetracoordinate Ni(II) catalysts dehydrogenate alcs. via a two-electron hydride transfer pathway involving energetically demanding nickel-centered redox events while in the presence of square planar Ni(II)-complexes dehydrogenation of alcs. proceeds via a one-electron hydrogen atom transfer (HAT) pathway via synergistic participation of metal and ligand centered redox processes avoiding high energy nickel centered redox events. Detailed substrate screening and control experiments were performed to unveil the reaction sequence and understand the advantages/disadvantages of these two pathways. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia