Day: January 6, 2023

Spatial and Temporal Distribution Characteristics and Potential Risks of Sulfonamides in the Shaanxi Section of the Weihe River was written by Duan, Lei;Yang, Siyue;Sun, Yaqiao;Ye, Fei;Jiang, Jie;Kou, Xiaomei;Yang, Fan. And the article was included in International Journal of Environmental Research and Public Health in 2022.Category: pyrimidines This article mentions the following:

The hazards of antibiotics as emerging contaminants to aquatic ecosystems and human health have received global attention. This study investigates the presence, concentration levels, spatial and temporal distribution patterns, and their potential risks to aquatic organisms and human health of sulfonamides (SAs) in the Shaanxi section of the Weihe River. The SA pollution in the Weihe River was relatively less than that in other rivers in China and abroad. The spatial and temporal distribution showed that the total concentrations of SAs in the Weihe River were highest in the main stream (ND-35.296 ng/L), followed by the south tributary (3.718-34.354 ng/L) and north tributary (5.476-9.302 ng/L) during the wet water period. Similarly, the order of concentration from highest to lowest during the flat water period was main stream (ND-3 ng/L), north tributary (ND-2.095 ng/L), and south tributary (ND-1.3 ng/L). In addition, the ecol. risk assessment showed that the SAs other than sulfadiazine (SDZ) and sulfamethoxazole (SMZ) posed no significant risk (RQS < 0.01) to the corresponding sensitive species during both periods, with no significant risk to human health for different age groups, as suggested by the health risk assessment. The risk of the six SAs to both aquatic organisms and human health decreased significantly from 2016 to 2021. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Category: pyrimidines).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Symmetry and polar-π effects on the dynamics of enshrouded aryl-alkyne molecular rotors was written by Karim, Arif R.;Linden, Anthony;Baldridge, Kim K.;Siegel, Jay S.. And the article was included in Chemical Science in 2010.Synthetic Route of C6H4N2 This article mentions the following:

The central ring of a 1,4-bis(arylethynyl)arene (ditolan) can be viewed as a mol. rotor with an extremely low barrier to rotation in the gas phase or solution The torsional energy profile of that ring is dependent on the relative conformation of the end capping arenes. When the capping arenes are sterically bulky m-terphenyl units, it is possible to rationalize the conformational dynamics of the central ring by a factorization anal., involving perturbation of the basic torsional energy profile by polar-π, and dispersion interactions between the flanking rings of the cap and the central ring of the ditolan. The symmetry of the construct can modulate the effect of these interactions. These principles apply to the design of materials in which a steric shroud excludes packing distortions. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Synthetic Route of C6H4N2).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Synthetic Route of C6H4N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Secondary amines immobilized inside magnetic mesoporous materials as a recyclable basic and oxidative heterogeneous nanocatalyst for the synthesis of trisubstituted pyrimidine derivatives was written by Aryan, Reza;Beyzaei, Hamid;Nojavan, Masoomeh;Dianatipour, Tahereh. And the article was included in Research on Chemical Intermediates in 2016.Product Details of 40230-24-8 This article mentions the following:

A novel magnetic MCM-41 nanocomposite-based catalyst is reported for the first time in the multicomponent synthesis of trisubstituted pyrimidines in which piperazine is immobilized inside the mesochannels of magnetic MCM-41 as an organic base (α-Fe₂O₃-MCM-41-piperazine). This nanocatalyst was thoroughly characterized by various techniques such as FT-IR, XRD, SEM, TEM, EDX and N₂-adsorption isotherms. Very uniform dispersion and ordered mesopores of α-Fe₂O₃-MCM-41 causes piperazine mols. to be distributed very finely on the internal surface of the pores, resulting in a very useful and robust magnetically recyclable amine-based heterogeneous nanocatalyst. This catalytic system showed remarkable activity in the solvent-free synthesis of 2,4,6-trisubstituted pyrimidine derivatives In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Product Details of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Product Details of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reaction of α,β-unsaturated ketones with guanidine. Substituent effects on the protonation constants of 2-amino-4,6-diarylpyrimidines was written by Al-Hajjar, Farouk H.;Sabri, Salim S.. And the article was included in Journal of Heterocyclic Chemistry in 1982.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

RCH:CHCOR¹ (R = e.g., Ph, p-MeC₆H₄, m-O₂NC₆H₄, p-FC₆H₄; R¹ = Ph, p-MeC₆H₄) is condensed with NH:C(NH₂)₂·HCl, in aqueous EtOH containing NaOH, to give the corresponding I. LFER for the protonation constants of I (R¹ = Ph, p-MeC₆H₄), in 50 volume% aqueous EtOH, vs. σ, σ^*_XC6H4, and a dual parameter Hammett equation in σ_R and σ_I were obtained. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

6-(4-Amino-1-methyl-2-(methylthio)-6-oxo-1,6-dihydropyrimidin-5-yl)-3,6-dimethyl-2-(methylthio)-6,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,5-dione was written by Romo, Pablo E.;Quiroga, Jairo;Insuasty, Braulio;Nogueras, Manuel;Cobo, Justo. And the article was included in Molbank in 2015.COA of Formula: C6H9N3OS This article mentions the following:

The title compound 6-(4-amino-1-methyl-2-(methylthio)-6-oxo-1,6-dihydropyrimidin-5-yl)-3,6-dimethyl-2-(methylthio)-6,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,5-dione was synthesized in 60% yield by a microwave-induced cyclocondensation reaction of aminopyrimidine with pyruvic acid in the presence of cerium ammonium nitrate (CAN) as catalyst. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7COA of Formula: C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A₃ Adenosine Receptor Antagonists was written by Cosimelli, Barbara;Greco, Giovanni;Ehlardo, Marina;Novellino, Ettore;Da Settimo, Federico;Taliani, Sabrina;La Motta, Concettina;Bellandi, Marusca;Tuccinardi, Tiziano;Martinelli, Adriano;Ciampi, Osele;Trincavelli, Maria Letizia;Martini, Claudia. And the article was included in Journal of Medicinal Chemistry in 2008.HPLC of Formula: 54030-56-7 This article mentions the following:

A number of derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine, e.g., I, were synthesized and biol. evaluated as A₃ adenosine receptor (A₃ AR) antagonists. The new compounds were designed as open chain analogs of a triazolopyrimidinone derivative displaying submicromolar affinity for the A₃ AR, which had been previously identified using a 3D database search. Substituents attached to the parent compound were chosen according to factorial design and stepwise lead optimization approaches, taking into account the essentially hydrophobic nature of the A₃ AR binding site. As a result, I was identified among the pyrimidine derivatives as the ligand featuring the best combination of potency and selectivity for the target receptor. This compound binds to the A₃ AR with a K_i of 3.5 nM and is devoid of appreciable affinity for the A₁, A_2A, and A_2B ARs. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7HPLC of Formula: 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Backbone-anchoring, solid-phase synthesis strategy to access a library of peptidouridine-containing small molecules was written by Arbour, Christine A.;Imperiali, Barbara. And the article was included in Organic Letters in 2022.Application In Synthesis of 2-Ethynylpyrimidine This article mentions the following:

Nucleoside diphosphate sugar (NDP-sugar) substrates provide the inspiration for nucleoside analog inhibitor scaffolds. By employing solid-phase synthesis, we provide a method to access a library of peptidouridine inhibitors with both minimal compound handling and purification steps. Specifically, this strategy is exemplified by generating uridine diphosphate sugar (UDP-sugar) mimics, which allow for compound elaboration by altering the dipeptide composition, the N-terminal linkage, and a pendant aryl group. To exemplify the versatility, 41 unique nucleoside analogs are presented. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Application In Synthesis of 2-Ethynylpyrimidine).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Application In Synthesis of 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mass spectra of pyrimidine derivatives. V. Methoxy- and dimethylaminopyrimidines was written by Ivanovskaya, L. Yu.;Derendyaev, B. G.;Baram, S. G.. And the article was included in Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk in 1982.Safety of 4-Chloro-2-methoxypyrimidine This article mentions the following:

The mass spectra of I (R = H, F, Cl), II (R = H, F; R¹ = H, F, Cl), III, IV (R = F, Cl), V, and VI (R = H, Cl; R¹ = H, Me, MeO, F, Cl, NO₂) were analyzed. In the case of VI (R = H), electron-donating R¹ substituents favored cleavage of a C-H bond in the OMe group, whereas electron-withdrawing R¹ favored loss of CH₂O. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-methoxypyrimidine (cas: 51421-99-9Safety of 4-Chloro-2-methoxypyrimidine).

4-Chloro-2-methoxypyrimidine (cas: 51421-99-9) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Safety of 4-Chloro-2-methoxypyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gold-nanoparticle-based multiplex immuno-strip biosensor for simultaneous determination of 83 antibiotics was written by Lei, Xianlu;Xu, Xinxin;Liu, Liqiang;Xu, Liguang;Wang, Li;Kuang, Hua;Xu, Chuanlai. And the article was included in Nano Research.Computed Properties of C11H12N4O3S This article mentions the following:

Antibiotic residues, generated by the irrational use of drugs and environmental pollution, have always been a great challenge to aquaculture safety. Therefore, a quick, convenient, and performance-excellent way to detect antibiotic residues in aquaculture fish is urgently required. In this study, a multiplex immunochromatog. strip biosensor based on gold nanoparticles was developed for the simultaneous detection of five classes of antibiotic residues (24 β-lactam antibiotics, 26 sulfonamides, five tetracyclines, 24 quinolones, and four amphenicols) in aquaculture fish within 10 min. The detection ranges of five representative antibiotics, penicillin G, sulfamethazine, tetracycline, enrofloxacin, and chloramphenicol, were 2.33-38.4, 0.688-17.1, 1.4-48.1, 1.45-32.9, and 0.537-9.06 μg/kg, resp. The accuracy and stability of these measurements were demonstrated by analyzing spiked fish samples, with recovery rates of 87.5%-115.2% and a coefficient of variation < 9.5%. The cross-reaction rates, based on the five representative antibiotics, were 3.77%-202% for β-lactams, 3.95%-137% for sulfonamides, 9.19%-100% for tetracyclines, 4.9%-145% for quinolones, and 3.2%-100% for amphenicols. The excellent testing performance of the biosensor strip to most of antibiotic residues in aquaculture fish ensures they meet the maximum residue limits required by countries or organizations. Therefore, this multiplex immunochromatog. strip biosensor is potentially applicable to the rapidly on-site determination of antibiotic residues in aquaculture fish. [graphic not available: see fulltext] In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Computed Properties of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Computed Properties of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis was written by Karaj, Endri;Sindi, Shaimaa H.;Kuganesan, Nishanth;Perera, Lalith;Taylor, William;Tillekeratne, L. M. Viranga. And the article was included in Journal of Medicinal Chemistry in 2022.Product Details of 37972-24-0 This article mentions the following:

Once considered potential liabilities, the modern era witnesses a renaissance of interest in covalent inhibitors in drug discovery. The available toolbox of electrophilic warheads is limited by constraints on tuning reactivity and selectivity. Following our work on a class of ferroptotic agents termed CETZOLEs, we discovered new tunable heterocyclic electrophiles which are capable of inducing ferroptosis. The biol. evaluation demonstrated that thiazoles with an alkyne electrophile at the 2-position selectively induce ferroptosis with high potency. D. functional theory calculations and NMR kinetic studies demonstrated the ability of our heterocycles to undergo thiol addition, an apparent prerequisite for cytotoxicity. Chemoproteomic anal. indicated several potential targets, the most prominent among them being GPX4 protein. These results were further validated by western blot anal. and the cellular thermal shift assay. Incorporation of these heterocycles into appropriate pharmacophores generated highly cytotoxic agents such as the analog BCP-T.A (I), with low nM IC₅₀ values in ferroptosis-sensitive cell lines. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Product Details of 37972-24-0).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Product Details of 37972-24-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia