Day: January 6, 2023

Occurrence and distribution of antibiotics in sediments from black-odor ditches in urban areas from China was written by Lv, Yin-Zhi;Luo, Xiao-Jun;Zhao, Jian-Liang;Wang, Shan-Quan;Mai, Bi-Xian. And the article was included in Science of the Total Environment in 2021.Product Details of 1220-83-3 This article mentions the following:

Antibiotic levels in black-odor water could reflect the usage amount of antibiotics in population. On the other hand, these antibiotics are the source of antibiotics in the environmental water. Currently, researches on antibiotics in black-odor sediments are still lacking. In this study, 174 black and odor sediment samples from 74 cities in 28 provinces in China were collected for anal. Among 44 targeted antibiotics, 13 antibiotics were detected in more than 30% of sediment samples. Fluoroquinolones and tetracyclines were the predominant antibiotics in these field samples, with average concentrations of up to 2074 and 1902 ng/g dry weight (dw), resp., followed by macrolides (87.9 ng/g dw), lincosamides (8.06 ng/g dw) and sulfonamides (8.38 ng/g dw). High antibiotic contamination levels were almost always detected in black-odor sludges from economically less developed small cities; however, the difference in antibiotic concentrations between well-developed and small cities in China was not statistically significant. In addition, among the seven regions within China, no significant difference in concentrations was observed for the most antibiotics. Variances in antibiotic composition patterns in the 28 provinces of China may be due to differences in bacterial resistance, prescription habits, efficacy, and sediment carbon concentrations among various regions. There were significant pos. correlations among some antibiotics in the same or different classes. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Product Details of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Product Details of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A practical and cost-effective approach to polysubstituted pyrimidine derivatives via DBU mediated redox isomerization of propargyl alcohol and subsequent N-C-N fragment condensation was written by De, Rimpa;Sengupta, Utsav;Savarimuthu, Antony;Misra, Souvik;Nanda, Jayanta;Bera, Mrinal K.. And the article was included in New Journal of Chemistry in 2022.HPLC of Formula: 40230-24-8 This article mentions the following:

A straightforward, efficient yet effortless approach for the synthesis of structurally important triarylated pyrimidine derivatives has been successfully developed using secondary propargyl alc. and com. available amidines under mild basic conditions. The reaction is believed to proceed via base-mediated redox isomerization of propargyl alc. into a chalcone and a subsequent N-C-N fragment condensation reaction with the in situ generated chalcone. The procedure may be successfully employed to generate a large array of polysubstituted pyrimidine derivatives from milligram to multigram scale. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8HPLC of Formula: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.HPLC of Formula: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidines. XLII. Synthesis of 2- and 6-substituted 4-fluoropyrimidines was written by Shkurko, O. P.;Baram, S. G.;Mamaev, V. P.. And the article was included in Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk in 1973.Reference of 51421-99-9 This article mentions the following:

4-Fluoropyrimidines I (R = H, Me Ph, OMe, CF3, F, NMe2, R1 = Me, H, Ph, F, MeO, NH2, NMe2) were prepared in 10-97% yields by fluorination of the corresponding chloropyrimidines by CsF in DMF or methylpyrrolidone and by nucleophilic substitution of a F atom in difluoro- and trifluoro- pyrimidines. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-methoxypyrimidine (cas: 51421-99-9Reference of 51421-99-9).

4-Chloro-2-methoxypyrimidine (cas: 51421-99-9) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 51421-99-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Simultaneous Determination of 21 Sulfonamides in Poultry Eggs Using Ionic Liquid-Modified Molecularly Imprinted Polymer SPE and UPLC-MS/MS was written by Suo, Decheng;Zhang, Su;Song, Zhanteng;Wang, Shi;Li, Yang;Fan, Xia. And the article was included in Molecules in 2022.Product Details of 1220-83-3 This article mentions the following:

An ionic liquid-modified molecularly imprinted polymer (IL-MIP) composite with sulfamethazine as a template mol. and Me acrylic acid and 1-aminopropyl-3-methylimidazolium bromide as functional monomers was successfully synthesized. The achieved IL-MIP was characterized and evaluated in detail and utilized in the extraction and cleanup of sulfonamides (SAs) in poultry egg samples. The results demonstrated that the IL-MIP possessed a broad reorganization toward SAs and could selectively adsorb 21 kinds of SA compounds Furthermore, the solid-phase extraction column based on the IL-MIP was used in the extraction and cleanup of 21 SAs in eggs, and the confirmatory detection of SAs was performed using ultraperformance liquid chromatog.-tandem mass spectrometry. Under optimum conditions, the limits of detection (LODs) for all SAs ranged from 0.1 ng·g-1 to 1.5 ng·g-1, and the LOD of this method was better than those of the existing methods. The recoveries of SA compounds spiked in egg samples ranged from 84.3% to 105.8%, with low relative standard deviations (<15%). The developed method based on the IL-MIP extraction and cleanup was successfully used in the detection of 21 SAs in more than 100 real poultry egg samples. The results indicated that the proposed method was suitable for detecting 21 SAs in poultry eggs. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Product Details of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Product Details of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Efficient discovery of novel antimicrobials through integration of synthesis and testing in crude ribosome extract was written by Sang, Zitai;Lu, Yongping;Zhou, Yuanzheng;Ju, Yuan;An, Qi;Shen, Silan;Shi, Jianyou;He, Jun;Yang, Tao;Luo, Youfu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.HPLC of Formula: 37972-24-0 This article mentions the following:

By coupling in situ [2+3] Huisgen cycloaddition with an in vitro transcription/translation luminescence assay in a crude ribosomal extract, a robust and accurate high-throughput platform was successfully developed and applied for efficient identification of novel structural types of ribosomal inhibitors with antimicrobial activity against drug-resistant bacteria. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0HPLC of Formula: 37972-24-0).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.HPLC of Formula: 37972-24-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

An Eco-Sustainable Synthetic Approach for 4,5-Dihydro-1H-pyrazoles via DBU Catalysis in Micellar Medium was written by Mishra, Anu;Rai, Pratibha;Pandey, Yogesh K.;Singh, Jaya;Singh, Jagdamba. And the article was included in ChemistrySelect in 2017.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

An efficient and straightforward synthetic strategy for pharmaceutically pertinent scaffold 4,5-dihydro-1H-pyrazoles I [R¹ = C₆H₅, 2-BrC₆H₄, 3,4-(OCH₃)₂C₆H₃, etc.; R² = C₆H₅, 3,4-(CH₃)₂C₆H₃] has been reported initiating from highly substituted chalcones R¹CH=CHC(O)R² and thiosemicarbazide as reactants in an aqueous micellar medium by the use of DBU (1,8-Diazabicyclo[5.4.0]undec-7-ene) as an organobase. The use of CTAB (Cetyl Tri-Me Ammonium Bromide) as a surfactant, which forms a colloidal dispersion with organic substrates with the enhancement of the reactivity of substrates, is the key feature of this technique. Organic synthesis in aqueous micellar medium, use of organocatalyst DBU, mild reaction conditions, sustainable synthesis, exptl. feasibility, broad substrate scope, short reaction time and high yields are some other attributes of this protocol. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse was written by Stauffer, Frederic;Weiss, Andreas;Scheufler, Clemens;Mobitz, Henrik;Ragot, Christian;Beyer, Kim S.;Calkins, Keith;Guthy, Daniel;Kiffe, Michael;Van Eerdenbrugh, Bernard;Tiedt, Ralph;Gaul, Christoph. And the article was included in ACS Medicinal Chemistry Letters in 2019.Quality Control of 2-Chloropyrimidine-4-carbonitrile This article mentions the following:

In MLL-rearranged cancer cells, disruptor of telomeric silencing 1-like protein (DOT1L) is aberrantly recruited to ectopic loci leading to local hypermethylation of H3K79 and consequently misexpression of leukemogenic genes. A structure-guided optimization of a HTS hit led to the discovery of DOT1L inhibitors with subnanomolar potency, allowing testing of the therapeutic principle of DOT1L inhibition in a preclin. mouse tumor xenograft model. Compounds displaying good exposure in mouse and nanomolar inhibition of target gene expression in cells were obtained and tested in vivo. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4Quality Control of 2-Chloropyrimidine-4-carbonitrile).

2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Quality Control of 2-Chloropyrimidine-4-carbonitrile

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Acetylinic ketones. Part II. Reaction of acetylenic ketones with nucleophilic nitrogen compounds was written by Baddar, F. G.;Al-Hajjar, F. H.;El-Rayyes, N. R.. And the article was included in Journal of Heterocyclic Chemistry in 1976.COA of Formula: C16H13N3 This article mentions the following:

PhCCCOR [I, R = Ph, C6H4Me-p, C6H4Cl-m, p, C6H4OMe-p, 3,4-(methylenedioxy)phenyl] reacted with H2NNHCO2R1 (R1 = Ph, Et) to give RCOCH:CPhNHNHCO2R1, which were cyclized with Ac2O to give the pyrazolecarboxylates II, which on hydrolysis-decarboxylation with MeOH-NaOH gave the aromatic pyrazoles III; I also reacted with NH2C(:NH)NH2 to give the pyrimidines IV; similarly, the pyrimidines V (Z = S, O) were prepared from heating PhCCCOPh with H2NC(:Z)NH2. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.COA of Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis, Characterization, and Anti-Amoebic Activity of N-(Pyrimidin-2-yl)benzenesulfonamide Derivatives was written by Bhat, Abdul Roouf;Arshad, Mohammad;Lee, Eun Ju;Pokharel, Smritee;Choi, Inho;Athar, Fareeda. And the article was included in Chemistry & Biodiversity in 2013.Related Products of 40230-24-8 This article mentions the following:

A new series of N-(pyrimidin-2-yl)benzenesulfonamide derivatives, were synthesized from pyrimidin-2-amines, with the aim to explore their effects on in vitro growth of Entamoeba histolytica. The chem. structures of the compounds were elucidated by elemental anal., FTIR, ¹H- and ¹³C-NMR, and ESI mass-spectral data. In vitro anti-amoebic activity was evaluated against HM1 : IMSS strain of Entamoeba histolytica. The IC₅₀ values were calculated by using the double dilution method. The results were compared with the IC₅₀ value of the standard drug ‘metronidazole’. The selected compounds were tested for their cytotoxic activities by cell-viability assay using H9C2 cardiac myoblasts cell line, and all the compounds displayed remarkable >80% viabilities to a concentration of 100 μg/mL. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Development and evaluation of a multi-class analytical method based on solid-phase extraction combined with liquid chromatography-tandem mass spectrometry for the analysis of pharmaceuticals and personal care products in urban wastewater samples was written by Konda, Satyanand;Asati, Ankita;Williams, Mike;Mudiam, Mohana Krishna Reddy. And the article was included in Separation Science plus in 2022.Computed Properties of C11H12N4O3S This article mentions the following:

An anal. method has been developed for the quant. evaluation of 64 pharmaceuticals and personal care products in urban wastewater using solid-phase extraction coupled with liquid chromatog.-tandem mass spectrometry. Design of experiments approach was used in the multiparametric optimization of solid-phase extraction method for the anal. of pharmaceuticals and personal care products. The method was found to be linear within the range of 0.01-1 μg/L with coefficient of determination (R²) ranging from 0.990 to 0.999. The limit of detection and limit of quantification were found to be in the range of 0.002-0.028 and 0.007-0.091 μg/L, resp. The accuracy was calculated with respect to percent recovery, and it was found to be in the range of 70.0-129% for all the analytes. The intra- and interday precisions were found to be less than 15% relative standard deviation for all the analytes. The developed anal. method was applied to real samples collected from four different sampling sites of Musi River in Hyderabad to evaluate its performance. The method found a wide application for the anal. of urban wastewater samples. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Computed Properties of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Computed Properties of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia