Month: January 2023

A radical approach for the selective C-H borylation of azines was written by Kim, Ji Hye;Constantin, Timothee;Simonetti, Marco;Llaveria, Josep;Sheikh, Nadeem S.;Leonori, Daniele. And the article was included in Nature (London, United Kingdom) in 2021.Product Details of 40230-24-8 This article mentions the following:

B functional groups are often introduced in place of aromatic C-H bonds to expedite small-mol. diversification through coupling of mol. fragments^1-3. Current approaches based on transition-metal-catalyzed activation of C-H bonds are effective for the borylation of many (hetero)aromatic derivatives^4,5 but show narrow applicability to azines (N-containing aromatic heterocycles), which are key components of many pharmaceutical and agrochem. products⁶. Here the authors report an azine borylation strategy using stable and inexpensive amine-borane⁷ reagents. Photocatalysis converts these low-mol.-weight materials into highly reactive boryl radicals⁸ that undergo efficient addition to azine building blocks. This reactivity provides a mechanistically alternative tactic for sp² C-B bond assembly, where the elementary steps of transition-metal-mediated C-H bond activation and reductive elimination from azine-organometallic intermediates are replaced by a direct, Minisci⁹-style, radical addition The strongly nucleophilic character of the amine-boryl radicals enables predictable and site-selective C-B bond formation by targeting the azine’s most activated position, including the challenging sites adjacent to the basic N atom. This approach enables access to aromatic sites that elude current strategies based on C-H bond activation, and led to borylated materials that would otherwise be difficult to prepare The authors have applied this process to the introduction of amine-borane functionalities to complex and industrially relevant products. The diversification of the borylated azine products by mainstream cross-coupling technologies establishes aromatic amino-boranes as a powerful class of building blocks for chem. synthesis. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Product Details of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Product Details of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Determination of sulfonamide antibiotics in fish and shrimp samples based on magnetic carbon nanotube dummy molecularly imprinted polymer extraction followed by UPLC-MS/MS was written by Gao, Lei;Qin, Dongli;Chen, Zhongxiang;Wu, Song;Tang, Shizhan;Wang, Peng. And the article was included in Electrophoresis in 2021.Reference of 1220-83-3 This article mentions the following:

In this study, a novel purification method using magnetic solid-phase extraction (MSPE) based on magnetic carbon nanotube dummy molecularly imprinted polymer (MCNTMIP) nanocomposite was investigated for separation and enrichment of sulfonamide antibiotics (SAs) in fish and shrimp samples. The MCNTMIP nanocomposite was successfully synthesized by applying carbon nanotubes as supporting template, methacrylic acid as functional monomer, sulfabenzamide as the dummy template for SAs, and ethylene glycol dimethacrylate as crosslinking agent, then was characterized by Fourier-transform IR spectrometry and vibrating sample magnetometry. The adsorption performance of MCNTMIP was evaluated by binding experiments, including static adsorption, kinetic adsorption, and selectivity recognition study. The results confirmed that an imprinted polymer layer was successfully constructed on the surface of the MCNTMIP and this sorbent has advantages of simple magnetic separation, specific mol. recognition, and high adsorption capacity. Combined with ultra-high performance liquid chromatog. tandem mass spectrometry (UPLC-MS/MS), we developed a rapid, sensitive, efficient MSPE method for detecting SAs analytes. Under the optimal conditions, the limits of detection were low to 0.1μg/kg, and the recoveries of SAs analytes were ranged between 90.2 and 99.9%. In addition, the precision values were ranged between 0.5 and 9.1%. This method was successfully applied to analyze SAs in fish and shrimp samples with satisfactory recoveries. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Reference of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China was written by Chen, Xiangping;Lei, Lei;Liu, Sitian;Han, Jian;Li, Ruiwen;Men, Jun;Li, Lin;Wei, Lin;Sheng, Yaqi;Yang, Lihua;Zhou, Bingsheng;Zhu, Lizhong. And the article was included in Science of the Total Environment in 2021.Related Products of 1220-83-3 This article mentions the following:

The consumption of pharmaceuticals and personal care products (PPCPs) for controlling and preventing the COVID-19 would have sharply increased during the pandemic. To evaluate their post-pandemic environmental impacts, 5 categories of drugs were detected in lakes and WWTP-river-estuary system near hospitals of Jinyintan, Huoshenshan, and Leishenshan in the 3 regions (Regions J, H and L) in Wuhan, China. The total amount of PPCPs (ranging 2.61-1122 ng/L in water and 0.11-164 ng/g dry weight in sediments) were comparable to historical reports in Yangtze River basin, whereas the detection frequency and concentrations of ribavirin and azithromycin were higher than those of historical studies. The distribution of concerned drugs varied with space, season, media, and water types: sampling sites located at WWTPs-river-estuary system around 2 hospitals (Regions L and J) usually had relatively high waterborne contamination levels, most of which declined in autumn; lakes had relatively low waterborne contamination levels in summer but increased in autumn. The potential risks of detected PPCPs were further evaluated using the multiple-level ecol. risk assessment (MLERA): sulfamethoxazole and azithromycin were found to pose potential risks to aquatic organisms according to a semi-probabilistic approach and classified as priority pollutants based on an optimized risk assessment. In general, the COVID-19 pandemic did not cause serious pollution in lakes and WWTPs-river-estuary system in Wuhan City. However, the increased occurrence of certain drugs and their potential ecol. risks need further attention. A strict source control policy and an advanced monitoring and risk warning system for emergency response and long-term risk control of PPCPs is urgent. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Related Products of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Discovery of 1-Methyl-1H-imidazole Derivatives as Potent Jak2 Inhibitors was written by Su, Qibin;Ioannidis, Stephanos;Chuaqui, Claudio;Almeida, Lynsie;Alimzhanov, Marat;Bebernitz, Geraldine;Bell, Kirsten;Block, Michael;Howard, Tina;Huang, Shan;Huszar, Dennis;Read, Jon A.;Rivard Costa, Caroline;Shi, Jie;Su, Mei;Ye, Minwei;Zinda, Michael. And the article was included in Journal of Medicinal Chemistry in 2014.Related Products of 938443-20-0 This article mentions the following:

Structure based design, synthesis, and biol. evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described. Using the C-ring fragment from our first clin. candidate AZD1480 (I), optimization of the series led to the discovery of compound II, a potent, orally bioavailable Jak2 inhibitor. Compound II displayed a high level of cellular activity in hematopoietic cell lines harboring the V617F mutation and in murine BaF3 TEL-Jak2 cells. Compound II demonstrated significant tumor growth inhibition in a UKE-1 xenograft model within a well-tolerated dose range. In the experiment, the researchers used many compounds, for example, 2,4,7-Trichloropyrido[2,3-d]pyrimidine (cas: 938443-20-0Related Products of 938443-20-0).

2,4,7-Trichloropyrido[2,3-d]pyrimidine (cas: 938443-20-0) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 938443-20-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Continuous antibiotic attenuation in algal membrane photobioreactor: Performance and kinetics was written by Kiki, Claude;Ye, Xin;Li, Xi;Adyari, Bob;Hu, Anyi;Qin, Dan;Yu, Chang-Ping;Sun, Qian. And the article was included in Journal of Hazardous Materials in 2022.Reference of 1220-83-3 This article mentions the following:

The attenuation of 10 mixed antibiotics along with nutrients in a continuous flow mode by four freshwater microalgae (Haematococcus pluvialis, Selenastrum capricornutum, Scenedesmus quadricauda, and Chlorella vulgaris) was examined in membrane photobioreactors (MPBRs). At lab-scale, consistent removal of both antibiotic and nutrient was shown by H. pluvialis and S. quadricauda, resp. The system exhibited better performance with enhanced removal at HRT 24 h compared to 12 h and 48 h. The highest removal efficiency of antibiotics was observed in H. pluvialis MPBR, with the mean antibiotic removal values of 53.57%- 96.33%. Biodegradation was the major removal pathway of the antibiotics in the algal-MPBR (AMPBR), while removal by bioadsorption, bioaccumulation, membrane rejection, and abiotic was minor. Then, the bacterial feature was studied and showed significant influence from system hydrodynamics. The kinetics of continuous flow antibiotic removal followed Stover-Kincannon and Grau second-order models, which revealed great potential of AMPBR to withstand antibiotic load. The latter coupled with the computational fluid dynamic simulation was successfully applied for the residual antibiotic prediction and potential system optimization. Overall, these results provide an important reference for continuous flow antibiotic removal using AMPBR. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Reference of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of 2-(p-aminophenylsulfonamido)4,5-dimethyl-pyrimidine was written by Sugasawa, Shigehiko;Yamada, Shun-ichi;Narahashi, Masuko. And the article was included in Yakugaku Zasshi in 1951.SDS of cas: 1193-74-4 This article mentions the following:

A suspension of 23 g. Na powder in 400 ml. C₆H₆ treated with 60 g. HCO₂Me and 72 g. MeCOEt dropwise at 5-10°, stirred 3 hrs., 150 ml. C₆H₆ added, the mixture poured slowly into 118 g. concentrated H₂SO₄ and 128 g. dry MeOH at 10°, stirred 4 hrs., neutralized with Na₂CO₃, filtered, and the filtrate distilled give 42.4 g. AcCHMeCH(OR)₂ (I) (R = Me), b₈ 68-73°; 30 ml. absolute alc., 6 g. CaCl₂, and 3 g. AcCHMeCHO in 2 ml. EtOH at 0-2°, let stand in a refrigerator 2 days, the alc. removed, and the residue taken up with ether and distilled give 2.5 g. I (R = Et), b₈ 81-4°. AcC(:CHONa)Me (II) (58 g.) in 120 ml. water treated with 42 g. Me₂SO₄ dropwise, kept 2 hrs. at 60-5°, extracted with C₆H₆, and the extract distilled give 22.3 g. AcCMe:CHOR (III) (R = Me), b₄ 62-4°; II with EtBr and p-MeC₆H₄SO₂Et in EtOH give III (R = Et), b₅ 71-5°. (CH₂OH)₂, (7.4 g.), 20.2 g. concentrated H₂SO₄, and 60 ml. C₆H₆ at 4-5° treated dropwise with 24.4 g. II, the mixture stirred 4 hrs., poured into water containing NaHCO₃, extracted with CHCl₃, and the extract distilled give 2.5 g. AcCHMeCH.O.CH₂.CH₂.O, b₄ 74-7°. Guanidine HNO₃ (0.56 g.) added to 0.12 g. Na in 6 ml. EtOH, the mixture filtered, the filtrate refluxed 2 hrs. with 0.6 g. I (R = Me), 0.12 g. Na, and 3 ml. EtOH, water added, the solution extracted with CHCl₃, and the product recrystallized from water give 0.2 g. 2-amino-4,5-dimethylpyrimidine (IV), m. 215-16°. p-AcHNC₆H₄SO₂NHC(:NH)NH₂ (V) (7 g.) in 70 ml. glacial AcOH refluxed 5 hrs. with 4 g. I (R = Me) in 10 ml. AcOH, the AcOH removed, water added, the mixture filtered, 5% NaOH added, the precipitated V filtered, and the filtrate acidified with AcOH give 6.1 g. 2-(p-AcHNC₆H₄SO₂NH) analog (VI) of IV, m. 270. Refluxing 1 g. VI 1 hr. in 10 ml. 10% NaOH, filtering with C, and acidifying the filtrate with AcOH give 0.7 g. 2-(p-H₂NC₆H₄SO₂NH) analog (VII) of VI, m. 220°. p-Me₂NC₆H₄SO₂NH₂ (2 g.) and 1.17 g. guanidine carbonate heated 1.5 hrs. at 210°, 5% NaOH added, and the mixture filtered give 1.9 g. p-Me₂NC₆H₄SO₂NHC(:NH)NH₂ (VIII), m. 248°. VIII (0.9 g.), 0.37 g. AcCHMeCHO, and 70 g. BuOH heated in a sealed tube 7 hrs. at 120°, the mixt filtered, the solid taken up in 10% NaOH, filtered, and the filtrate acidified with AcOH give 0.51 g. 2-(p-Me₂NC₆H₄SO₂NH) analog (IX) of IV, m. 235°. Letting 1.3 g. urea in 50 ml. EtOH, 3.6 g. I (R = Et), and 7 ml. concentrated HCl stand on ice several days gives 1.3 g. 2-HO analog (X) of IV; HCl salt, decompose 250°. X (4 g.) in 10% KOH evaporated to dryness, the residue added to 20 ml. POCl₃ with ice cooling, the mixture heated on an oil bath 3 hrs., the POCl₃ removed in vacuo, and the residue poured in ice water, neutralized with NaOH, and with C₆H₆ gives 1.3 g. 2-Cl analog (XI) of IV, m. 22.5-6°. In the experiment, the researchers used many compounds, for example, 4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4SDS of cas: 1193-74-4).

4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.SDS of cas: 1193-74-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Elevated levels of antibiotic resistance in groundwater during treated wastewater irrigation associated with infiltration and accumulation of antibiotic residues was written by Kampouris, Ioannis D.;Alygizakis, Nikiforos;Kluemper, Uli;Agrawal, Shelesh;Lackner, Susanne;Cacace, Damiano;Kunze, Steffen;Thomaidis, Nikolaos S.;Slobdonik, Jaroslav;Berendonk, Thomas U.. And the article was included in Journal of Hazardous Materials in 2022.Application of 1220-83-3 This article mentions the following:

Treated wastewater irrigation (TWW) releases antibiotics and antibiotic resistance genes (ARGs) into the environment and might thus promote the dissemination of antibiotic resistance in groundwater (GW). We hypothesized that TWW irrigation increases ARG abundance in GW through two potential mechanisms: the contamination of GW with resistant bacteria and the accumulation of antibiotics in GW. To test this, the GW below a real-scale TWW-irrigated field was sampled for six months. Sampling took place before, during and after high-intensity TWW irrigation. Samples were analyzed with 16S rRNA amplicon sequencing, qPCR of six ARGs and the class 1 integron-integrase gene intI1, while liquid chromatog. tandem mass spectrometry was performed to detect antibiotic and pharmaceutical residues. Absolute abundance of 16S rRNA in GW decreased rather than increased during long-term irrigation. Also, the relative abundance of TWW-related bacteria did not increase in GW during long-term irrigation. In contrast, long-term TWW irrigation increased the relative abundance of sul1 and intI1 in the GW microbiome. Furthermore, GW contained elevated concentrations of sulfonamide antibiotics, especially sulfamethoxazole, to which sul1 confers resistance. Total sulfonamide concentrations in GW correlated with sul1 relative abundance. Consequently, TWW irrigation promoted sul1 and intI1 dissemination in the GW microbiome, most likely due to the accumulation of drug residues. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Principles of determination of main tautomers of six-membered heteroaromatic compounds was written by Mkhitaryan, A. V.;Papoyan, R. F.;Avetisyan, A. A.. And the article was included in Hayastani Kimiakan Handes in 2006.Category: pyrimidines This article mentions the following:

The principles of determination of the main tautomers of any mono- and majority of di- and trisubstituted pyridines and diazines have been suggested in the present work. A difference in the electronegativity of the heteroatom X (X = O, NH, S) in the single, two or three XH groups contained in the aromatic form of the present compound is taken in the base of these principles. The two most stable tautomeric forms of each above mentioned heterocycle are determined without drawing in any results of its exptl. or theor. investigations. An application of the systemic approach to the investigation of the tautomerism of six-member heteroaromatic compounds permits to isolate among great number of isomeric structures of the present compounds those which may to be in the equilibrium one with another. Therefore, the potential reaction ability of the present mono-, di- and trisubstituted pyridine or diazine may be easily revealed after the determining of the whole number of such structures among which its main tautomers contain also. The trustworthiness of the principles indicated above has been confirmed by means of quantum-chem. calculations of the heats of formation for all those isomeric structures by means of which the present compound may be represented. Such calculations carried by means of PM-3 method correspond completely to the principles of determination of the main tautomers of the present compound for sufficiently great number of different mono-, di- and trisubstituted six-member heterocycles. In the experiment, the researchers used many compounds, for example, 5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0Category: pyrimidines).

5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Determining a wide range of antibiotics and pesticides in poultry feathers using selective accelerated solvent extraction-liquid chromatography-mass spectrometry was written by Wu, Huizhen;Zhou, Min;Xu, Jie;Wang, Jianmei;Tong, Jianying;Sun, Nabo;Qian, Mingrong. And the article was included in Analytical Methods in 2022.Product Details of 1220-83-3 This article mentions the following:

This study established a detection method based on accelerated solvent extraction-liquid chromatog.-mass spectrometry for determining residues of 3 chloramphenicols, 8 macrolides, 18 sulfonamides, 4 nitroimidazoles, 15 insecticides, and 22 fungicides in poultry feathers. The extraction solvent, methanol, was used for a static extraction time of 5 min, and repeated three times. Fifty milligrams of adsorbents C18/PSA (1 : 1, W/W) were added to the extraction cell to achieve simultaneous extraction and purification The extraction efficiency of three solvents, methanol, acetonitrile and Et acetate, was investigated. An orthogonal exptl. design was used to explore the optimal combination of extraction temperature, static extraction time, number of extraction cycles, and adsorbent ratio for accelerated solvent extraction After the optimal ratio was determined, the dosage of adsorbents was optimized. The extracted sample solution was concentrated by blowing nitrogen, redissolved, passed through a 0.22 μm PTFE membrane filter, then injected for instrumental anal. The validation results showed that the recovery of the proposed method was 60.4-107.6%, the limit of detection 0.2-3.0 μg kg^-1, and the limit of quantification 0.5-8.3 μg kg^-1. This quant. multi-residue detection method was able to determine the residues of 70 target compounds in poultry feathers. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Product Details of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Product Details of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

2-Amino- and 2-guanidino-4-thiazolylpyrimidines was written by Lipinski, Christopher A.;Craig, Rebecca H.;Wright, Roger B.. And the article was included in Journal of Heterocyclic Chemistry in 1985.SDS of cas: 75833-38-4 This article mentions the following:

Synthesis of the four amino- and guanidinothiazolylpyrimidines I [R,R¹ = NH₂, NHC(:NH)NH₂] is described and pKa values are calculated Guanidinopyrimidines are more basic than guanidinothiazoles. However, the reverse is true of the amino heterocycles; the aminothiazole is more basic than the aminopyrimidine. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4SDS of cas: 75833-38-4).

2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.SDS of cas: 75833-38-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia