Warczykowska, Iwona et al. published their research in Polish Journal of Chemistry in 1980 | CAS: 75833-38-4

2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Formula: C5H2ClN3

Synthesis of new pyrimidine-4-carboxylic acid derivatives was written by Warczykowska, Iwona;Wojciechowski, Jan. And the article was included in Polish Journal of Chemistry in 1980.Formula: C5H2ClN3 This article mentions the following:

Aminolysis of 2-chloro-4-cyanopyridine (I) gave the nitriles II [R = cyano; R1 = H, R2 = 4-ClC6H4, 2-MeOC6H4, 4-Me2NC6H4; R1 = R2 = Et; R1R2 = (CH2CH2)2O] which were hydrolyzed with 5% aqueous NaOH to the acids II (R = CO2H). Treatment of I with NaOMe-MeOH gave the ester III which was hydrolyzed to the acid with aqueous NaOH. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4Formula: C5H2ClN3).

2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Formula: C5H2ClN3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Petrocchi, Alessia et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2016 | CAS: 20090-58-8

4-Chloro-5-methylpyrimidin-2-amine (cas: 20090-58-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.COA of Formula: C5H6ClN3

Identification of potent and selective MTH1 inhibitors was written by Petrocchi, Alessia;Leo, Elisabetta;Reyna, Naphtali J.;Hamilton, Matthew M.;Shi, Xi;Parker, Connor A.;Mseeh, Faika;Bardenhagen, Jennifer P.;Leonard, Paul;Cross, Jason B.;Huang, Sha;Jiang, Yongying;Cardozo, Mario;Draetta, Giulio;Marszalek, Joseph R.;Toniatti, Carlo;Jones, Philip;Lewis, Richard T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.COA of Formula: C5H6ClN3 This article mentions the following:

Structure based design of a novel class of aminopyrimidine MTH1 (MutT homolog 1) inhibitors is described. Optimization led to identification of I, a sub-nanomolar inhibitor of MTH1 with excellent cell permeability and good metabolic stability in microsomes. This compound robustly inhibited MTH1 activity in cells and proved to be an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncol. In the experiment, the researchers used many compounds, for example, 4-Chloro-5-methylpyrimidin-2-amine (cas: 20090-58-8COA of Formula: C5H6ClN3).

4-Chloro-5-methylpyrimidin-2-amine (cas: 20090-58-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.COA of Formula: C5H6ClN3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

D’Alarcao, Marc et al. published their research in Journal of Organic Chemistry in 1985 | CAS: 4319-77-1

5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 4319-77-1

Synthesis of imidazo[4,5-h]-1,3-diazabiphenylene (lin-benzocyclobutadienopurine), a ring system having a benzocyclobutadieno spacer between the terminal rings of purine was written by D’Alarcao, Marc;Bakthavachalam, Venkatesalu;Leonard, Nelson J.. And the article was included in Journal of Organic Chemistry in 1985.Application of 4319-77-1 This article mentions the following:

Two distinct syntheses of the pyrimido[6,5-i]imidazo[4,5-g]cinnoline ring system were accomplished. The first of these began with 2-acetamido-4-chloro-5-nitroacetophenone, which was elaborated sequentially by fusion of the imidazole, pyridazine, and pyrimidine rings to provide the tetracyclic system. The second synthesis made use of a Pd-catalyzed cross-coupling reaction of (4,6-dimethoxypyrimidin-5-yl)zinc chloride and 3,4-dinitrobromobenzene, followed by closure of the imidazole and pyridazine rings. The flash vacuum pyrolysis (810-860°, 10-3 torr) of the unsubstituted tetracyclic compound, pyrimido[4,5-i]imidazo[4,5-g]cinnoline, resulted in the extrusion of N to provide imidazo[4,5-h]-1,3-diazabiphenylene (I), the parent mol. to a new class of linearly extended purine analogs. In the experiment, the researchers used many compounds, for example, 5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1Application of 4319-77-1).

5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 4319-77-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Okafor, Charles O. et al. published their research in European Journal of Medicinal Chemistry in 1977 | CAS: 63931-22-6

5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine (cas: 63931-22-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine

Studies in the heterocyclic series. XIII. New CNS-depressants derived from 1,9-diazaphenoxazine and two isomeric triazaphenothiazine ring systems was written by Okafor, Charles O.;Steenberg, Marie L.;Buckley, Joseph P.. And the article was included in European Journal of Medicinal Chemistry in 1977.Safety of 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine This article mentions the following:

Triazaphenothiazines I (R = NH2, H, SMe, OMe; R1 = NH2, Me, Cl, OH, OMe) and II (R = H, NH2, Cl; R1 = NH2, OH, Cl; R2 = MeO, Cl) were prepared in 78-93% yield. Reaction of 2-amino-3-mercapto-6-picoline with 2-amino-5-bromo-4-chloro-6-methylpyrimidine in the presence of H2SO4 and Na2SO3 gave 77% I (R = NH2, R1 = Me). All I and II showed appreciable CNS depressant activities comparable with the activity of chlorpromazine when tested in mice and rats; I (R = H, R1 = NH2) and II (R = R1 = Cl, R2 = MeO) were the most promising. All I and II decreased motor activity and rate of respiration within 30 min and body temperature was decreased by 0.5-1.9° compared to 0.8° with chlorpromazine. In the experiment, the researchers used many compounds, for example, 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine (cas: 63931-22-6Safety of 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine).

5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine (cas: 63931-22-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sengar, Ragini et al. published their research in International Journal of Chemical Sciences in 2007 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 4,6-Diphenylpyrimidin-2-amine

Synthesis and characterization of some pyrimidine compounds was written by Sengar, Ragini;Tyagi, Sushma;Gazal, Umaima;Pathak, Vishal;Verma, Ranu;Pathak, P.. And the article was included in International Journal of Chemical Sciences in 2007.Name: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Some pyrimidine compounds have been synthesized via heterocyclization of dibromochalcones. The structures of the prepared compounds were characterized using elementary anal., IR, NMR and mass spectrometry. Fragmentation patterns for these compounds were given. The important IR-bands were assigned to the corresponding groups. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Name: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kautny, Paul et al. published their research in Chemistry – A European Journal in 2016 | CAS: 37972-24-0

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Name: 2-Ethynylpyrimidine

Structure-Property Relationships in Click-Derived Donor-Triazole-Acceptor Materials was written by Kautny, Paul;Bader, Dorian;Stoeger, Berthold;Reider, Georg A.;Froehlich, Johannes;Lumpi, Daniel. And the article was included in Chemistry – A European Journal in 2016.Name: 2-Ethynylpyrimidine This article mentions the following:

To shed light on intramol. charge-transfer phenomena in 1,2,3-triazole-linked materials, a series of 1,2,3-triazole-linked push-pull chromophores were prepared and studied exptl. and computationally. Investigated modifications include variation of donor and/or acceptor strength and linker moiety as well as regioisomers. Photophys. characterization of intramol. charge-transfer features revealed ambipolar behavior of the triazole linker, depending on the substitution position. Furthermore, non-centrosym. materials were subjected to second-harmonic generation measurements, which revealed the high nonlinear optical activity of this class of materials. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Name: 2-Ethynylpyrimidine).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Name: 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gupton, John T. et al. published their research in Journal of Heterocyclic Chemistry in 1991 | CAS: 90905-32-1

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Safety of 2-Methoxypyrimidine-5-carbaldehyde

An alternative preparation of the 2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane salt from phosphonoacetic acids and some applications in heterocyclic synthesis was written by Gupton, John T.;Gall, John E.;Riesinger, Steve W.;Smith, Stanton Q.;Bevirt, Kathy M.;Sikorski, James A.;Dahl, Maria L.;Arnold, Zdenek. And the article was included in Journal of Heterocyclic Chemistry in 1991.Safety of 2-Methoxypyrimidine-5-carbaldehyde This article mentions the following:

An alternative preparation of Me2N+:CHCR:CHNMe2 . n ClO4 (I; R = CHN+Me2; n = 2) from phosphonoacetic acid is described along with its application to the synthesis of 5-formylpyrimidines, e.g., II (R1 = Me, OMe, SMe, NH2, NMe2, NHEt, Ph) and masked 4-formylpyrazoles III (Ar = substituted Ph) via cyclization with RC(NH2):NH or ArNHNH2, resp. I (R = H; n = 1), thought to be an intermediate in the preparation of I (R = CHN+Me2; n = 2) was also isolated. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Safety of 2-Methoxypyrimidine-5-carbaldehyde).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Safety of 2-Methoxypyrimidine-5-carbaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Szesni, Normen et al. published their research in Organometallics in 2006 | CAS: 37972-24-0

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 2-Ethynylpyrimidine

Unprecedented Allenylidene Transfer from Chromium to Tungsten was written by Szesni, Normen;Drexler, Matthias;Fischer, Helmut. And the article was included in Organometallics in 2006.Quality Control of 2-Ethynylpyrimidine This article mentions the following:

Pyrimidylallenylidene complexes 1 ([(CO)5M:C:C:C(NC3H3NEt)]; M = Cr (a), W (b)) were prepared in a 1-pot procedure from readily available 2-ethynylpyrimidine, BuLi, [(CO)5M(THF)], and triethyloxonium tetrafluoroborate. In addition to 1a,b, the homobinuclear allenylidene complexes 2a,b ([(CO)5M:C:C:C(NC3H3NEt)M(CO)5]; M = Cr, W) were formed. In 2a,b the 2nd (CO)5M moiety is attached to the non-alkylated N atom of the pyrimidyl ring. Treatment of the Cr complex 1a with an excess of [(CO)5W(THF)] afforded the W allenylidene complex 2b by transmetalation of the allenylidene ligand and addition of (CO)5W. The allenylidene ligands of other Cr allenylidene complexes [(CO)5Cr:C:C:C(R1)R2] could likewise be transferred to W. In contrast, the reverse transmetalation from W to Cr could not be achieved. DFT calculations indicate that the reaction proceeds by an associative rather than a dissociative pathway. The initiating reaction step is coordination of a (CO)5W fragment to the Cα-Cβ bond of the allenylidene ligand. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Quality Control of 2-Ethynylpyrimidine).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gallagher, John F. et al. published their research in Acta Crystallographica, Section C: Crystal Structure Communications in 2004 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Product Details of 40230-24-8

N-H…N hydrogen bonding in 4,6-diphenyl-2-pyrimidinylamine isolated from the plant Justicia secunda (Acanthaceae) was written by Gallagher, John F.;Goswami, Shyamaprosad;Chatterjee, Baidyanath;Jana, Subrata;Dutta, Kalyani. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2004.Product Details of 40230-24-8 This article mentions the following:

The title compound, C16H13N3, isolated from Justicia secunda (Acanthaceae), comprises two mols. (which differ slightly in conformation) in the asym. unit of space group P1̅. Crystallog. data are given. Intermol. Namino-H…Npyrm interactions (Npyrm is a pyrimidine ring N atom) involve only one of the two donor amino H atoms and pyrimidine N atoms per mol., forming dimeric units via R22(8) rings, with N…N distances of 3.058(2) and 3.106(3) Å, and N-H…N angles of 172.7(18) and 175.8(17)°. The dimers are linked by C-H…π(arene) contacts, with an H…centroid distance of 2.77 Å and a C-H…centroid angle of 141°. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Product Details of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Product Details of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Li, Bo et al. published their research in Tetrahedron Letters in 2020 | CAS: 257280-25-4

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C10H7BrN2O

Microwave-assisted synthesis of 2,5-disubstituted pyrimidine derivatives via Buchwald-Hartwig amination was written by Li, Bo;Etheve-Quelquejeu, Melanie;Yen-Pon, Expedite;Garbay, Christiane;Chen, Huixiong. And the article was included in Tetrahedron Letters in 2020.Formula: C10H7BrN2O This article mentions the following:

Various 2,5-disubstituted pyrimidine derivatives I (R = 4-cyanophenyl, 3-tert-butyl-1-methyl-1H-pyrazol-5-yl, 4-[ethoxy(oxo)methane]phenyl, etc.; R1 = H; RR1 = -(CH2)2O(CH2)2-, -(CH2)2CH(N-(CH2)4-)(CH2)2-; R2 = H, Ph, dimethylaminyl, 4-cyclohexylpiperazin-1-yl, etc.) were synthesized under microwave irradiation via Buchwald-Hartwig amination. This concise approach provides interesting scaffolds in good to high yields and with large functional group compatibility. These novel chem. entities could be used as building blocks in drug design. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4Formula: C10H7BrN2O).

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C10H7BrN2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia