5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 4319-77-1
Synthesis of imidazo[4,5-h]-1,3-diazabiphenylene (lin-benzocyclobutadienopurine), a ring system having a benzocyclobutadieno spacer between the terminal rings of purine was written by D’Alarcao, Marc;Bakthavachalam, Venkatesalu;Leonard, Nelson J.. And the article was included in Journal of Organic Chemistry in 1985.Application of 4319-77-1 This article mentions the following:
Two distinct syntheses of the pyrimido[6,5-i]imidazo[4,5-g]cinnoline ring system were accomplished. The first of these began with 2-acetamido-4-chloro-5-nitroacetophenone, which was elaborated sequentially by fusion of the imidazole, pyridazine, and pyrimidine rings to provide the tetracyclic system. The second synthesis made use of a Pd-catalyzed cross-coupling reaction of (4,6-dimethoxypyrimidin-5-yl)zinc chloride and 3,4-dinitrobromobenzene, followed by closure of the imidazole and pyridazine rings. The flash vacuum pyrolysis (810-860°, 10-3 torr) of the unsubstituted tetracyclic compound, pyrimido[4,5-i]imidazo[4,5-g]cinnoline, resulted in the extrusion of N to provide imidazo[4,5-h]-1,3-diazabiphenylene (I), the parent mol. to a new class of linearly extended purine analogs. In the experiment, the researchers used many compounds, for example, 5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1Application of 4319-77-1).
5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 4319-77-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia