Day: February 9, 2023

High-throughput screening of 756 chemical contaminants in aquaculture products using liquid chromatography/quadrupole time-of-flight mass spectrometry was written by Bai, Mingkai;Tang, Ruixue;Li, Guorong;She, Wenhai;Chen, Gangjun;Shen, Hongmei;Zhu, Suqin;Zhang, Hongwei;Wu, Haohao. And the article was included in Food Chemistry: X in 2022.SDS of cas: 1220-83-3 This article mentions the following:

A high-throughput screening method embracing 756 multiclass chem. contaminants in aquaculture products was developed using modified QuEChERS extraction coupled with liquid chromatog./quadrupole time-of-flight mass spectrometry. A mega-database with retention time/accurate mass data for 524 pesticides, 182 veterinary drugs, 32 persistent organic pollutants and 18 marine toxins was established for compound identification via retrospective library searching. In the four representative matrixes (muscle tissues of tilapia and grouper, and edible portions of oyster and scallop), all the database compounds showed acceptable recovery and repeatability with the screening detection limit and limit of quantification below 0.01 mg/kg for >90% of them. The matrix-matched calibration revealed acceptable quant. property of the method in terms of linear range, linearity, and matrix effect, and fish muscle samples showed stronger matrix effect than shellfish samples. Anal. of 64 real-life samples from aquaculture farms and retail markets evidenced applicability of the proposed method to high-throughput screening scenarios. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3SDS of cas: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.SDS of cas: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pd/PTABS: Catalyst for Room Temperature Amination of Heteroarenes was written by Murthy Bandaru, Siva Sankar;Bhilare, Shatrughn;Chrysochos, Nicolas;Gayakhe, Vijay;Trentin, Ivan;Schulzke, Carola;Kapdi, Anant R.. And the article was included in Organic Letters in 2018.Electric Literature of C8H10ClN3O This article mentions the following:

A mild and highly efficient catalytic amination procedure for chloroheteroarenes at ambient temperature using the Pd/PTABS catalytic system is reported. The protocol is selective for the amination of chloroheteroarenes using secondary amines such as piperidine, pyrrolidine, and several others. The exceptional mildness of the developed protocol is beneficial for the synthesis of a crucial Buparlisib intermediate as well as the formal synthesis of Alogliptin in competitive yields. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Electric Literature of C8H10ClN3O).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Electric Literature of C8H10ClN3O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A simple and rapid immunochromatography test based on readily available filter paper modified with chitosan to screen for 13 sulfonamides in milk was written by Zeng, Yuyang;Liang, Demei;Zheng, Pimiao;Zhang, Yanfang;Wang, Zile;Mari, Ghulam Mujtaba;Jiang, Haiyang. And the article was included in Journal of Dairy Science in 2021.HPLC of Formula: 1220-83-3 This article mentions the following:

In this study, we developed a novel, simple, rapid, and low-cost colloidal gold-based immunochromatog. method, with filter paper replacing nitrocellulose membrane as the substrate. To obtain adequately immobilized protein, chitosan was used to functionalize the filter paper. After conditions and parameters were optimized, the novel immunochromatog. method was applied for detection of sulfonamide residues in milk. Quant. detection was accomplished using a smartphone and Photoshop software (Adobe Inc., San Jose, CA), allowing us to screen 13 sulfonamides with a limit of detection ranging from 0.42 to 8.64μg/L and recovery ranging from 88.2 to 116.9% in milk. The proposed novel method performed similarly to the conventional method that uses a nitrocellulose membrane as the transport medium, and it had lower cost and better usability because of the inexpensive and easily available filter paper. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3HPLC of Formula: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.HPLC of Formula: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A simple and highly efficient synthesis of novel fluorinated 4,6-disubstituted aminopyrimidines using Cd(OAc)₂ was written by Kumar, Amit;Kumari, Poonam;Bhagat, Sunita. And the article was included in Synthetic Communications in 2020.Related Products of 40230-24-8 This article mentions the following:

A highly efficient fluorination reaction of 4,6-disubstituted aminopyrimidines I (R¹ = C₆H₅, 4-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 2-thienyl; R² = H, OMe, F, Cl, Br, Me; X = H) using N-Fluorobenzenesulfonimide (NFSI) has been developed, presumably proceeding via C-H bond activation. Cadmium acetate was employed as the salts, and various fluorinated 4,6-disubstituted aminopyrimidines I (X = F) have been generated in good to excellent yields. This chem. endows an economical method of valuable fluorinated 4,6-disubstituted aminopyrimidines I (X = F) through a direct C-F bond formation. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Triazine-pyrimidine based molecular hybrids: synthesis, docking studies and evaluation of antimalarial activity was written by Kumar, Deepak;Khan, Shabana I.;Ponnan, Prija;Rawat, Diwan S.. And the article was included in New Journal of Chemistry in 2014.Related Products of 62968-37-0 This article mentions the following:

A series of novel triazine-pyrimidine hybrids have been synthesized and evaluated for their in vitro antimalarial activity. Some of the compounds showed promising antimalarial activity against both CQ-sensitive and CQ-resistant strains at micromolar level with a high selectivity index. All the compounds displayed better activity (IC₅₀ = 1.32-10.70 μM) than the standard drug pyrimethamine (>19 μM) against the chloroquine-resistant strain W2. All the tested compounds were nontoxic against mammalian cell lines. Docking studies of the most active compounds were performed on both wild type and quadruple mutant (N51I, C59R, S108N, I164L) PfDHFR-TS using Glide to analyze the interaction of the compounds with the binding site of the protein. The binding poses of compounds I and II, having a high Glide XP score and the lowest Glide energies, show an efficient binding pattern similar to that of the DHFR substrate (dihydrofolate) in the wild type and mutant DHFR active site. The anal. of the pharmacokinetic properties of the most active compounds using ADMET prediction attests to the possibility of developing compound I as a potent antimalarial lead. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Related Products of 62968-37-0).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 62968-37-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Preparation of heterocycles by the reaction of diaza binucleophiles with chalcones: influence of the substituent on position 2 was written by Simon, Dominique;Lafont, Olivier;Farnoux, Claude Combet;Miocque, Marcel. And the article was included in Journal of Heterocyclic Chemistry in 1985.COA of Formula: C16H13N3 This article mentions the following:

The reaction of PhCH:CRCOPh (R = Br, NET₂, OPh, Bz, SPh, NO₂, H) with R¹NHNH₂ gave various hydrazine derivatives or the pyrazoles I or pyrazolines II. Reaction with thiourea or guanidine gave the pyrimidines III and IV (R = H, OPh, SPh). In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Intelligently identifiable membrane immunochip sensor based on Braille-like code for simultaneous multi-veterinary drug detection was written by Xiao, Xiaoyue;Huang, Yanmei;Zhao, Xuelong;Bao, Huanhuan;Lu, Zhongwei;Shan, Shan;Liu, Daofeng;Lai, Weihua. And the article was included in Sensors and Actuators, B: Chemical in 2022.Recommanded Product: 1220-83-3 This article mentions the following:

There may be risk of multiple veterinary drug residues in one food sample; thus, a key challenge for the simultaneous detection of multiple targets was raised in food safety anal. In this study, a multi-dot membrane immunochip sensor (MIS) based on Braille-like code was proposed for the sensitive, specific, and simultaneous detection of four veterinary drugs: sulfamethazine (SMZ), amantadine (AMD), danfloxacin (DAN), and tylosin (TYL). The 16 types of residual situations for four veterinary drugs can be qual. and quant. analyzed through the Braille-like code and signal intensity of dots. In addition, an Android application was exploited to intelligently identify the Braille-like code pattern; thus, the residue situations of the corresponding veterinary drugs can be automatically output by a smartphone. The cutoff values were 25 ng/mL for the four veterinary drugs by the naked eye. The limits of detection for SMZ, AMD, DAN, and TYL were calculated as 0.22, 0.058, 0.29, and 0.14 ng/mL, resp. To verify the performance of this multi-dot MIS, spiked chicken samples with different concentrations were tested, and the results verified the accuracy and precision of this method. The average spiked recoveries were 79.2-116.7%, and the coefficient of variation was 1.6-10.5%. Flexible, versatile and intelligent discriminant methods give this multi-dot MIS great potential to rapidly recognize complex situations in the field of simultaneous detection of analytes. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Recommanded Product: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides was written by Kanagarajan, V.;Thanusu, J.;Gopalakrishnan, M.. And the article was included in European Journal of Medicinal Chemistry in 2010.Formula: C16H13N3 This article mentions the following:

Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides I (R¹ = H, F, Me; R² = H, F, MeO) were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The min. inhibitory concentration tested against the same set of bacterial and fungal strains showed that I (R¹ = F, R² = H) against β-Hemolytic streptococcus and Klebsiella pneumoniae and I (R¹ = R² = F) against Escherichia coli and Pseudomonas had excellent antibacterial activity. Compounds I (R¹ = F, R² = H, MeO) showed inhibition against Aspergillus flavus, I (R¹ = Me, R² = F) against Microsporum gypseum, I (R¹ = F, R² = MeO) against Mucor, and compounds I (R¹ = Me, R² = MeO; R¹ = R² = F) against Rhizopus. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Background ions into exclusion list: A new strategy to enhance the efficiency of DDA data collection for high-throughput screening of chemical contaminations in food was written by Tan, Haiguang;Sun, Feifei;Abdallah, Mohamed F.;Li, Jianxun;Zhou, Jinhui;Li, Yi;Yang, Shupeng. And the article was included in Food Chemistry in 2022.Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Foods contaminated with hazardous compounds, could pose potential risks for human health. To date, there is still a big challenge in accurate identification. In this study, a novel data-dependent acquisition (DDA) approach, based on a combination of inclusion list and exclusion list, was proposed to acquire more effective MS/MS spectra. This strategy was successfully applied in a large-scale screening survey to detect 50 mycotoxins in oats, 155 veterinary drugs in dairy milk, and 200 pesticides in tomatoes. Compared with traditional acquisition modes, this new strategy has higher detection rate, particularly at ultra-low concentration by eliminating background influence, thereby generating the MS/MS spectra for more potential hazardous materials instead of matrix interference. Addnl., the obtained MS/MS spectra are simpler and more likely to be traced back than DIA. Moreover, this new strategy would be more comprehensively applied in food safety monitoring with the improvement of HRMS and post-acquisition techniques. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Thermodynamic Understanding of an Aza-Michael Reaction Enables Five-Step Synthesis of the Potent Integrin Inhibitor MK-0429 was written by Gupta, Anya;Condakes, Matthew L.. And the article was included in Journal of Organic Chemistry in 2021.SDS of cas: 90905-32-1 This article mentions the following:

A general strategy for the aza-Michael addition of nucleophilic heterocycles into β-substituted acrylates using potassium tert-butoxide as catalyst was describe . Demonstrating that the reaction is under thermodn. control underpins optimization efforts and enables rapid exploration of the substrate scope, with yields ranging from 55% to 94%. It was further leverage these lessons in a significantly shortened synthesis of MK-0429, a potent pan-integrin inhibitor previously taken into human clin. trials for the treatment of prostate cancer and osteoporosis. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1SDS of cas: 90905-32-1).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.SDS of cas: 90905-32-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia