Day: February 9, 2023

Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones was written by Cui, Xue;Ma, Jianting;Zeng, Tingting;Xu, Junyu;Li, Youbin;Wang, Xuesong. And the article was included in RSC Advances in 2021.Application of 40230-24-8 This article mentions the following:

A convenient metal-free synthesis of unsym. 2-aminopyrimidines I [R¹ = cyclopropyl, Ph, 4-MeC₆H₄, etc.; R² = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, etc.] from imidazolate enaminones had been developed. In this procedure, various structural 2-aminopyrimidines I, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represented an effective strategy toward the synthesis of unsym. 2-aminopyrimidines I. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Application of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Aminopyrimidines as electron-rich azadienes: extension of the synthetic potential of hetero Diels-Alder reactions under acidic conditions was written by Garcia, Celeste;Melguizo, Manuel;Cobo, Justo;Sanchez, Adolfo;Nogueras, Manuel;Lopez, Ma Dolores;Low, John N.. And the article was included in Synlett in 2001.SDS of cas: 54030-56-7 This article mentions the following:

By addition of a catalytic amount of a strong acid and selection of the appropriate solvent, the cycloaddition reactions of MeO₂CCCCO₂Me (DMAD) to 6-pyrimidinamines drastically changed their course leading to pyrrolo[3,4-c]pyridines, while, in the absence of acid, 6-amino-3,4-pyridinedicarboxylates were obtained. This change was interpreted on the basis of acid interception of the non-isolable adducts formed by initial hetero Diels-Alder cycloaddition between the reactants. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7SDS of cas: 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.SDS of cas: 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

One-pot synthesis and in vitro microbiological evaluation of pyrimidinyl thiazolidinones catalyzed by activated fly ash in dry media was written by Kanagarajan, V.;Gopalakrishnan, M.. And the article was included in Pharmaceutical Chemistry Journal in 2010.Recommanded Product: 40230-24-8 This article mentions the following:

Novel bioactive 2-phenyl-3-(4,6-diarylpyrimidin-2-yl)thiazolidin-4-ones were synthesized with good yields in a short reaction time by 1-pot multicomponent reaction of 2-amino-4,6-diarylpyrimidines, PhCHO, and thioglycolate under microwave irradiation in the presence of an activated fly ash catalyst in dry medium. The characterization of these compounds was performed by m.p., elemental anal., mass spectra, FT-IR, and ¹H and ¹³C NMR. In search for new leads toward potent antimicrobial agents, all the synthesized compounds were tested in vitro for their antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida 6, and Candida 51, and the results were discussed. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Recommanded Product: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of cyano-substituted heterocycles by tetraethylammonium cyanide was written by Hermann, Klaus;Simchen, Gerhard. And the article was included in Liebigs Annalen der Chemie in 1981.Product Details of 75833-38-4 This article mentions the following:

RCN (R = optionally substituted 2-pyridinyl, 4-pyrimidinyl, 4-quinazolinyl, 2-quinazolinyl, 2-quinoxalinyl) were prepared by treating RCl with NMe₃ and treating RN⁺Me₃ Cl^– with Et₄N⁺ CN^– to give RCN. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4Product Details of 75833-38-4).

2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Product Details of 75833-38-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A nanocomposite adsorbent of metallic copper, polypyrrole, halloysite nanotubes and magnetite nanoparticles for the extraction and enrichment of sulfonamides in milk was written by Jullakan, Sirintorn;Bunkoed, Opas. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2021.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

A composite adsorbent composed of metallic copper (Cu), polypyrrole (PPy), halloysite nanotubes (HNTs) and magnetite nanoparticles (Fe3O4) was developed to extract and enrich sulfonamides by dispersive magnetic solid phase extraction The composite could adsorb sulfonamides via hydrogen bonding and hydrophobic, π-π and π-electron-metal interactions. The extraction conditions were optimized and the developed composite adsorbent was characterized and provided a large surface area that enhanced extraction efficiency for sulfonamides. Coupled with high performance liquid chromatog., the adsorbent was used to quant. determine sulfonamides found in milk samples. The response of the developed method exhibited linearity from 5.0 to 150.0μg kg-1 for sulfathiazole, and from 2.5 to 100.0μg kg-1 for sulfamerazine, sulfamonomethoxine and sulfadimethoxine. Limits of detection were between 2.5 and 5.0μg kg-1. Recoveries of sulfonamides in milk samples ranged from 83.0 to 99.2% with RSDs lower than 6%. The developed composite adsorbent showed good reproducibility and reusability. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Palladium(0)/NHC-Catalyzed Reductive Heck Reaction of Enones: A Detailed Mechanistic Study was written by Raoufmoghaddam, Saeed;Mannathan, Subramaniyan;Minnaard, Adriaan J.;de Vries, Johannes G.;Reek, Joost N. H.. And the article was included in Chemistry – A European Journal in 2015.Application of 16879-39-3 This article mentions the following:

We have studied the mechanism of the palladium-catalyzed reductive Heck reaction of para-substituted enones with 4-iodoanisole by using N,N-diisopropylethylamine (DIPEA) as the reductant. Kinetic studies and in situ spectroscopic anal. have provided a detailed insight into the reaction. Progress kinetic anal. demonstrated that neither catalyst decomposition nor product inhibition occurred during the catalysis. The reaction is first order in the palladium and aryl iodide, and zero order in the activated alkene, N-heterocyclic carbene (NHC) ligand, and DIPEA. The experiments with deuterated solvent ([D₇]DMF) and deuterated base ([D₁₅]Et₃N) supported the role of the amine as a reductant in the reaction. The palladium complex [Pd⁰(NHC)(1)] has been identified as the resting state. The kinetic experiments by stopped-flow UV/Vis also revealed that the presence of the second substrate, benzylideneacetone 1, slows down the oxidative addition of 4-iodoanisole through its competing coordination to the palladium center. The kinetic and mechanistic studies indicated that the oxidative addition of the aryl iodide is the rate-determining step. Various scenarios for the oxidative addition step have been analyzed by using DFT calculations (bp86/def2-TZVP) that supported the inhibiting effect of substrate 1 by formation of resting state [Pd⁰(NHC)(1)] species at the cost of further increase in the energy barrier of the oxidative addition step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application of 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

N-Metallacycles from [Cp^*MX₂]₂ and Alkynylpyridines: Synthesis, Reaction Pathway, and Aromaticity was written by Teo, Jing Wei;Sridevi, Venugopal Shanmugham;Leong, Weng Kee. And the article was included in Organometallics in 2014.Electric Literature of C6H4N2 This article mentions the following:

The reaction of [Cp^*MX₂]₂ (M = Rh or Ir, X = Cl, Br, or I) with alkynylpyridines afforded halogen-substituted N-metallacyclic complexes. The reaction pathway has been examined through deuterium labeling and other experiments and computational studies and is proposed to proceed via halide dissociation followed by attack at the alkyne. These N-metallacycles exhibit aromaticity and undergo Sonogashira coupling reactions. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Electric Literature of C6H4N2).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Electric Literature of C6H4N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Investigation of the reaction of 6-amino-3-methyl-4-oxo-3,4-dihydro-2-pyrimidinylhydrazine was written by Moustafa, M. A.;Gineinah, M. M.;Bayomi, S. M.;Ismaiel, A. M.. And the article was included in Archives of Pharmacal Research in 1990.Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:

The hydrazine derivative I was utilized for the synthesis of three different fused 1,2,4-triazolo [4,3-a]pyrimidine derivatives II (R = H, R¹ = C₆H₄Cl-p, SH; R = CHO, R¹ = H) and a tetrazolo[1,5-a]pyrimidine derivative III. Reaction of I with the chalcone analog 2-thenylidene-2′-acetothienone, gave the pyrazoline derivative IV. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Evaluating sewer exfiltration in groundwater by pharmaceutical tracers after the 2016 Kumamoto earthquakes, Japan was written by Kobayashi, Jun;Kuroda, Keisuke;Miyamoto, Chinatsu;Uchiyama, Yukiko;Sankoda, Kenshi;Nakajima, Daisuke. And the article was included in Journal of Hazardous Materials in 2021.Computed Properties of C11H12N4O3S This article mentions the following:

In Apr. 2016, a series of earthquakes (M 7.3 on the Japan Meteorol. Agency scale) occurred in Kumamoto, Japan causing serious damage to underground sewerage networks. In this study, we evaluated sewer exfiltration in groundwater in the Kumamoto area after the earthquakes by using multiple tracers. We used 14 pharmaceuticals, including carbamazepine and crotamiton, and anthropogenic Gd as tracers, and we measured concentrations of these tracers from Sept. 2016 to Nov. 2017 seasonally. The detection frequency of caffeine, carbamazepine, crotamiton, ibuprofen, and anthropogenic Gd ranged from 29% to 45%, and the concentrations of the pharmaceuticals in the groundwater were lower than those in previous studies. The median of all pharmaceutical concentrations did not decrease, whereas the median of the sum of crotamiton and carbamazepine concentrations, which are quant. sewage markers, decreased with time. The sewer exfiltration rates in Sept. 2016 estimated using carbamazepine, crotamiton, and anthropogenic Gd were 0.59 ± 0.27%, 0.66 ± 0.47%, and 0.11 ± 0.18% of sewage dry weather flow, resp., indicating that the effect of the earthquakes on sewer exfiltration was small, probably because the damaged sewers were quickly repaired. This study demonstrated that a multiple-tracer approach is useful for evaluating sewer exfiltration after major earthquakes. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Computed Properties of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Computed Properties of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heterocycles. 41. Preparation of substituted 3,4-dihydro-2(1H)-pyrimidinimines and 2-aminopyrimidines from guanidine and α,β-unsaturated ketones was written by Wendelin, Winfried;Harler, Anton. And the article was included in Monatshefte fuer Chemie in 1975.Related Products of 40230-24-8 This article mentions the following:

HN:C(NH2)2 reacted with RCOCR1:CHR3[R = Me, Ph3R1 = H, Me; R2 = H, Me, Ph, or R1R2 = (CH2)9] to give the unstable dihydropyrimidinimines I, which dehydrogenated to give the corresponding 2-pyrimidinamines II. The unstable I[R = Ph, R1 = H, R2 = Me; R-R2 = Me; R = Me, R1R2 = (CH2)4] were isolated as the corresponding stable 1H-2-pyrimidinium and 1H-2-quinazolinium picrates, whereas I(R = R2 = Ph, R1 = H) was isolated as its hydrochloride. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia