Day: February 13, 2023

Investigation in the pyrimidine series V. Acylation of 6-amino-4-oxodihydropyrimidines was written by Pfleiderer, Wolfgang;Liedek, Egon. And the article was included in Justus Liebigs Annalen der Chemie in 1957.Synthetic Route of C6H9N3OS This article mentions the following:

Acylation in the 6-amino-4-oxodihydropyrimidine system occurred in normal fashion on the amino group, as determined by synthesis and by ultraviolet spectral data. NH.CS.NH.CO.CH:CNH₂ (I) (14.3 g.) dissolved in 140 cc. H₂O and 14 cc. concentrated NH₄OH by warming, 42 g. Raney Ni added portionwise at 80鎺? the mixture refluxed 3 hrs., filtered hot, the filtrate kept several hrs. in the refrigerator, the precipitate (II) filtered off, the filtrate concentrated to furnish a 2nd fraction (III), and II and III combined and recrystallized from H₂O gave 6.7 g. N:CH.NH.CO.CH:CNH₂ (IV), m. 271-2鎺?(decomposition). IV (5 g.) and 50 cc. Ac₂ refluxed 30 min., cooled, and the precipitate collected (addnl. material by concentrating the filtrate) and recrystallized from H₂O gave 5.4 g. 6-AcNH analog (V), m. 288-9鎺? I (57 g.) in 600 cc. 2N NaOH treated slowly at 40鎺?with 150 cc. Me₂SO₄ with stirring (a pH of 9 maintained toward the end of the methylation), the precipitate filtered off after 6 hrs., dried, digested with Et₂O, filtered off, and recrystallized from H₂O gave 48 g. N:C(SMe).NMe.CO.CH:CNH₂ (VI), m. 257鎺? VI (17.1 g.) and 120 cc. Ac₂O refluxed 30 min., cooled, the precipitate collected, and recrystallized from aqueous EtOH gave 9.2 g. 6-AcNH analog (VII), m. 251鎺? To 17.1 g. VI in 400 cc. H₂O was added 17.1 g. Raney Ni at 80鎺? refluxed 3.5 hrs., filtered hot, the filtrate concentrated to 1/3 its volume, the concentrate kept several hrs. in the refrigerator, the precipitate filtered off, and recrystallized from H₂O to give 6.5 g. N:CH.NMe.CO.CH:CNH₂ (VIII), m. 184-5鎺? III (3.7 g.) in 25 cc. 2N NaOH treated dropwise at 40鎺?with 5 cc. Me₂SO₄ with stirring while maintaining a pH of 9 at all times, the mixture neutralized with AcOH, extracted continuously 8 hrs. with CHCl₃, the extract dried, evaporated, and the residue recrystallized from H₂O gave 1.3 g. VIII. V (3.8 g.) in 40 cc. N NaOH treated as above with 4 cc. Me₂SO₄ gave 2.1 g. N:CH.NMe.CO.CH:CNHAc (IX), m. 303-4鎺? VIII (4.1 g.) and 20 cc. Ac₂O refluxed 15 min., cooled, the precipitate filtered off, and crystallized from H₂O gave 3 g. IX. VII (7.1 g.) in 200 cc. H₂O treated portionwise with 50 g. Raney Ni, refluxed 4 hrs., filtered hot, the filtrate concentrated to 1/3 its volume, cooled, the precipitate collected, and crystallized from H₂O gave 4.5 g. IX. N:CS.NH.CO.CMe:CNH₂ (15.7 g.) in 200 cc. H₂O treated with 45 g. Raney Ni, refluxed 4 hrs., filtered hot, the filtrate cooled several hrs. in ice, and the precipitate crystallized from H₂O gave 10 g. N:CH.NH.CO.CMe:CNH₂ (X), m. 243鎺? X (3.1 g.) and 9 cc. Ac₂O refluxed 15 min., cooled, and the precipitate recrystallized from H₂O gave 2 g. 6-AcNH analog, m. 303鎺? In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Synthetic Route of C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reaction of N-(carbamimidoyl)thiourea with 1-benzoyl-2-phenylacetylene was written by Glotova, T. E.;Dvorko, M. Yu.;Albanov, A. I.;Protsuk, N. I.. And the article was included in Russian Journal of Organic Chemistry in 2007.SDS of cas: 40230-24-8 This article mentions the following:

1-Benzoyl-2-phenylacetylene reacted with N-(carbamimidoyl)thiourea H₂NC(:S)NHC(:NH)NH₂ in glacial acetic acid saturated with 20% HBr to give (4,6-diphenyl-2H-1,3-thiazin-2-ylidene)guanidine hydrobromide. The reaction of the same compounds in anhydrous EtOH in the presence of NaOEt led to the formation of N-(4,6-diphenylpyrimidin-2-yl)thiourea. Bis(3-oxo-1,3-diphenylprop-1-en-1-yl) sulfide and 1-benzoyl-2-ethylsulfanyl-2-phenylethylene were isolated in the reactions of 1-benzoyl-2-phenylacetylene with N-(carbamimidoyl)thiourea and N-(carbamimidoyl)-S-ethylisothiuronium bromide, resp., in anhydrous MeOH. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8SDS of cas: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Disrupting Transcription and Folate Biosynthesis Leads to Synergistic Suppression of Escherichia coli Growth was written by Chen, Pei-Hsin;Sung, Li-Kang;Hegemann, Julian D.;Chu, John. And the article was included in ChemMedChem in 2022.Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The use of synergistic antibiotic combinations has emerged as a viable approach to contain the rapid spread of antibiotic-resistant pathogens. Here we report the discovery of a new strongly synergistic pair – microcin J25 and sulfamonomethoxine. The former is a lasso peptide that inhibits the function of RNA polymerase and the latter is a sulfonamide antibacterial agent that disrupts the folate pathway. Key to our discovery was a screening strategy that focuses on an antibiotic (microcin J25) that targets a hub (transcription) in the densely interconnected network of cellular pathways. The rationale was that disrupting such a hub likely weakens the entire network, generating weak links that potentiate the growth inhibitory effect of other antibiotics. We found that MccJ25 potentiates five other antibiotics as well. These results showcase the merit of taking a more targeted approach in the search and study of synergistic antibiotic pairs. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors was written by Martinez-Gonzalez, Sonia;Alvarez, Rosa M.;Martin, Jose I.;Garcia, Ana Belen;Riesco-Fagundo, Concepcion;Varela, Carmen;Rodriguez Hergueta, Antonio;Gonzalez Cantalapiedra, Esther;Albarran, M. I.;Gomez-Casero, Elena;Cebria, Antonio;Aguirre, Enara;Ajenjo, Nuria;Cebrian, David;Di Geronimo, Bruno;Cunningham, Darren;O閳ョ澇eill, Michael;Dave, Harish P. G.;Blanco-Aparicio, Carmen;Pastor, Joaquin. And the article was included in ACS Medicinal Chemistry Letters in 2021.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine This article mentions the following:

The PI3K/AKT/mTOR and PIM kinase pathways contribute to the development of several hallmarks of cancer. Cotargeting of these pathways has exhibited promising synergistic therapeutic effects in liquid and solid tumor types. To identify mols. with combined activities, we cross-screened our collection of PI3K/(鍗TOR) macrocycles (MCXs) and identified the MCX thieno[3,2-d]pyrimidine derivative 2 as a moderate dual PI3K/PIM-1 inhibitor. We report the medicinal chem. exploration and biol. characterization of a series of thieno[3,2-d]pyrimidine MCXs, which led to the discovery of IBL-302 (31), a potent, selective, and orally bioavailable triple PI3K/mTOR/PIM inhibitor. IBL-302, currently in late preclin. development (AUM302), has recently demonstrated efficacy in neuroblastoma and breast cancer xenografts. Addnl., during the course of our experiments, we observed that macrocyclization was essential to obtain the desired multitarget profile. As a matter of example, the open precursors 35-37 were inactive against PIM whereas MCX 28 displayed low nanomolar activity. In the experiment, the researchers used many compounds, for example, 4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine).

4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Casein Kinase 1鏈?钄?Inhibitor PF-5006739 Attenuates Opioid Drug-Seeking Behavior was written by Wager, Travis T.;Chandrasekaran, Ramalakshmi Y.;Bradley, Jenifer;Rubitski, David;Berke, Helen;Mente, Scot;Butler, Todd;Doran, Angela;Chang, Cheng;Fisher, Katherine;Knafels, John;Liu, Shenping;Ohren, Jeff;Marconi, Michael;DeMarco, George;Sneed, Blossom;Walton, Kevin;Horton, David;Rosado, Amy;Mead, Andy. And the article was included in ACS Chemical Neuroscience in 2014.Application In Synthesis of 4-Dimethoxymethylpyrimidin-2-ylamine This article mentions the following:

Casein kinase 1 delta (CK1鏈? and casein kinase 1 epsilon (CK1钄? inhibitors are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing a CNS kinase inhibitor has been limited by an inability to identify safe brain-penetrant compounds with high kinome selectivity. Guided by structure-based drug design, potent and selective CK1鏈?钄?inhibitors have now been identified that address this gap, through the design and synthesis of novel 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine derivatives PF-5006739 (6) possesses a desirable profile, with low nanomolar in vitro potency for CK1鏈?钄?(IC₅₀ = 3.9 and 17.0 nM, resp.) and high kinome selectivity. In vivo, 6 demonstrated robust centrally mediated circadian rhythm phase-delaying effects in both nocturnal and diurnal animal models. Further, 6 dose-dependently attenuated opioid drug-seeking behavior in a rodent operant reinstatement model in animals trained to self-administer fentanyl. Collectively, our data supports further development of 6 as a promising candidate to test the hypothesis of CK1鏈?钄?inhibition in treating multiple indications in the clinic. In the experiment, the researchers used many compounds, for example, 4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6Application In Synthesis of 4-Dimethoxymethylpyrimidin-2-ylamine).

4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Application In Synthesis of 4-Dimethoxymethylpyrimidin-2-ylamine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Risk assessment and investigation of landfill leachate as a source of emerging organic contaminants to the surrounding environment: a case study of the largest landfill in Jinan City, China was written by Wang, Kun;Reguyal, Febelyn;Zhuang, Tao. And the article was included in Environmental Science and Pollution Research in 2021.Synthetic Route of C11H12N4O3S This article mentions the following:

Emerging organic contaminants (EOCs) have been widely studied in landfill leachates but not in the surrounding environment of landfills. In this study, two sampling campaigns were conducted to determine 45 EOCs in landfill leachates and environmental samples near a landfill in East China. Our study focused on the seasonal occurrence and spatial distribution of the target EOCs, as well as their ecol. risks. The results showed 13 out of 45 EOCs were detectable and achieved individual concentrations that ranged from 2.0 to 5080 ng/L in the landfill leachates. Most of the detected EOCs exhibited higher concentrations in the leachates collected in summer than in winter. The contamination levels of the target EOCs in groundwater decreased with the distance of sampling sites from the landfill. In soil samples, the occurrence of target EOCs was not consistent with raw or treated landfill leachates. Risk assessment suggested that the individual EOC likely posed medium to high risks to aquatic organisms in groundwater while negligible impacts to human health through consumption of vegetables. To the best of our knowledge, this is the first report on the contribution of landfill leachates to EOC contamination in both aquatic and soil environments in East China. Our findings emphasized the importance of investigating EOCs in landfill leachates and accumulative environmental risks of EOCs in the neighboring environment of landfills in China. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Occurrence of antibiotics in the different biological treatment processes, reclaimed wastewater treatment plants and effluent-irrigated soils was written by Pu, Miao;Ailijiang, Nuerla;Mamat, Anwar;Chang, Jiali;Zhang, Qiongfang;Liu, Yifan;Li, Nanxin. And the article was included in Journal of Environmental Chemical Engineering in 2022.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Reclaimed wastewater is increasingly being used for agricultural irrigation to address water scarcity, particularly in arid and semiarid areas. In this study, the occurrence and removal of 24 antibiotics were investigated in two wastewater treatment systems (WWTSs) and their irrigation areas located in the arid northwestern region of China. The different WWTSs included absorption-biodegradation (AB) + anaerobic-anoxic-oxic (AAO) and AAO + AAO + membrane bioreactor (MBR). Nineteen antibiotics were detected, with concentrations ranging from low to 60.8娓璯/L. The dominant antibiotic classes were quinolones (QNs) and macrolides (MLs) in winter, and MLs and sulfonamides (SAs) in summer. The AAO + AAO + MBR system exhibited better removal efficiencies for most antibiotics, improving their adsorption and biodegradation Except for ofloxacin (OFC) and norfloxacin (NFC), the concentrations of the detected antibiotics were higher in summer than in winter. However, the antibiotic removal efficiency increased by 2-141% in summer compared to winter due to the increase in microbial activity with temperature Even though reclaimed treatment water plants contributed to the removal of antibiotics, residual antibiotics still affected the soil environment after green irrigation. In irrigated soil, QNs were predominantly detected, with a maximum concentration of 150.9 ng/kg for NFC. An ecol. risk assessment showed that OFC, NFC, enrofloxacin, and lomefloxacin presented low or medium ecol. risks in at least two irrigated sites. Thus, more attention should be given to the reuse of reclaimed wastewater, as it may pose toxicity risks to organisms in the soil environment. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Transformation of food waste to source of antimicrobial proteins by black soldier fly larvae for defense against marine Vibrio parahaemolyticus was written by Zhang, Shouyu;Xiong, Pu;Ma, Yongsheng;Jin, Ning;Sun, Shibo;Dong, Xiaoying;Li, Xiaodong;Xu, Jianqiang;Zhou, Hao;Xu, Weiping. And the article was included in Science of the Total Environment in 2022.Reference of 1220-83-3 This article mentions the following:

Insect biorefinery by black soldier fly larvae (BSFL), Hermetia illucens, has emerged as an innovative technique for the valorization of food waste. However, despite BSFL being an attractive natural source of antimicrobial proteins (AMPs), there is a scarcity of research on the antimicrobial activity and transcriptome expression of AMPs derived from BSFL following waste treatment. In the present study, food waste treatment was performed by BSFL with a substrate C/N ratio ranging from 21:1 to 10:1, marine Vibrio parahaemolyticus (VP) was selected as the model aquaculture pathogen, the antimicrobial activities of AMPs in vitro and zebrafish in vivo were examined, and the mol. mechanism of the C/N-dependent AMP difference was expounded. Findings were made that the AMP extract of C/N16:1 resulted in relatively higher antimicrobial activity in vitro than that of other C/Ns. Further, the AMPs of C/N16:1 exhibited a promising in vivo defense effect for elevating the 96-h survival rate of zebrafish from 0% to 39% after VP infection, comparable to the animal antibiotic sulfamethoxidine. The results of transcriptome anal. reveal that lysozymes were the highest expressed components in the AMP gene family. The C/N16:1 BSFL significantly up-regulated 12 out of 51 lysozyme genes compared with C/N21:1, which likely contributed to the improvement of AMP antimicrobial activity. Further, C/N16:1 significantly up-regulated the expression of lysozyme, glycosyl hydrolase and muscle protein genes compared with C/N21:1, which likely enhanced the defense ability of the immune system, the utilization of the starch-like substrate, and the mobility of the larvae, thereby facilitating the larval transformation and AMP production Overall, such results indicate that waste C/N ratio interacted with the activity and expression of BSFL AMPs through transcriptome regulation, and the BSFL AMPs derived from food waste could be used for the defense against marine pathogens to support the sustainable development of aquaculture. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Reference of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Reference of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Dynamics of antibiotics and antibiotic resistance genes in four types of kitchen waste composting processes was written by Zhao, Changxun;Xin, Liqing;Xu, Xingkun;Qin, Yong;Wu, Weixiang. And the article was included in Journal of Hazardous Materials in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Kitchen waste might be a potential source of antibiotics and antibiotic resistance genes. Composting is recognized as an effective way for kitchen waste disposal. However, the effects of different kitchen waste composting types on the removal of antibiotics and antibiotic resistance genes haven’t been systematically studied. In this study, the dynamics of antibiotics and antibiotic resistance genes from kitchen waste of four composting processes were compared. Showed that although kitchen waste was composted, it remained an underestimated source of antibiotics (25.9-207.3娓璯/kg dry weight) and antibiotic resistance genes (1012-1017 copies/kg dry weight). Dynamic composting processes (i.e., dynamic pile composting and mech. composting) decreased the antibiotic removal efficiency and increased the abundance of some antibiotic resistance genes (5.35-8534.7% enrichment). Partial least-squares path model anal. showed that mobile genetic elements played a dominant role in driving antibiotic resistance genes dynamics. Furthermore, redundancy anal. revealed that temperature, pH, and water content considerably affected the removal of antibiotics and mobile genetic elements. This study provides further insights into exploring the effective strategies in minimizing the risk of antibiotic resistance from kitchen waste via composting process. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Seasonal occurrence of multiple classes of antibiotics in East China rivers and their association with suspended particulate matter was written by Wang, Kun;Su, Zhaoxin;Reguyal, Febelyn;Bian, Rongxing;Li, Weihua;Yu, Haofeng;Sun, Yingjie;Zhuang, Ying;Shang, Wan. And the article was included in Science of the Total Environment in 2022.Synthetic Route of C11H12N4O3S This article mentions the following:

Understanding the occurrence and fate of antibiotics from different categories is vital to predict their environmental exposure and risks. This study presents the spatiotemporal occurrence of 45 multi-class antibiotics and their associations with suspended particulate matter (SPM) in Xiaoqing River (XRB) and Yellow River (YRB) via 10-mo monitoring in East China. Thirty-five and 31 antibiotics were detected in XRB and YRB, resp. Among them, fluoroquinolones (FQs) had the highest total mean concentration (up to 24.8娓璯/L in XRB and 15.4娓璯/L in YRB), followed by sulfonamides (SAs) (14.0娓璯/L and 15.4娓璯/L) and macrolides (MLs) (1.1娓璯/L and 1.6娓璯/L). Significant spatial-temporal variations were found in both rivers where higher concentrations of antibiotics were observed in urban and densely populated areas during winter and spring. Hydrol. factors such as river flow and water volume, instream attenuation and antibiotic usage may cause the observed variabilities in the seasonal patterns of antibiotic pollution. Using linear regression anal., for the first time, this study confirmed that the total concentrations of MLs (p < 0.05), FQs (p < 0.001) and SAs (p < 0.001) were strongly correlated with the turbidity/total suspended solids in the studied rivers (except MLs in YRB). It is thus suggested that partitioning processes onto SPM might affect the distribution of detected antibiotics in rivers, which are largely dependent on SPM composition and characteristics. The risk quotient (RQ) determined for up to 87% of individual compound was below 0.1 in both rivers; however, the high joint toxicity reflected by the mixed RQs of detected antibiotics may rise risk alarm for aquatic species. Further aspects regarding active mechanisms of SPM-antibiotic interactions and ecol. risks of coexistence of multiple antibiotics need to be investigated. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia