Month: February 2023

Antibiotics biomonitored in urine and obesogenic risk in a community-dwelling elderly population was written by Sang, Yanru;Zhang, Jingjing;Liu, Kaiyong;Wang, Qunan;Wang, Sufang;Sheng, Jie;Wang, Li;Zhang, Dongmei;Li, Xiude;Cao, Hongjuan;Liu, Annuo;Tao, Fangbiao. And the article was included in Ecotoxicology and Environmental Safety in 2021.Electric Literature of C11H12N4O3S This article mentions the following:

Exptl. and epidemiol. studies have linked antibiotics use to gut dysbiosis-mediated risk of chronic metabolic diseases. However, whether adiposity is linked to antibiotic exposure in elderly remains inadequately understood. To investigate the association between internal exposure of antibiotics and adiposity in elderly by using a biomonitoring method. We included 990 participants (≥ 60 years) from the baseline survey of the Cohort of Elderly Health and Environment Controllable Factors in Lu’an city, China, from June to Sept. 2016. Forty-five antibiotics and two metabolites in urine were monitored through liquid chromatog.-electrospray tandem mass spectrometry (HPLC-MS/MS). Creatinine-corrected urinary concentrations were used to assess antibiotic exposure levels. Body mass index (BMI), waist circumference (WC) and body fat percentage (BFP) were used as indicators of adiposity. Multiple linear regression and binary logistic regression analyses were used to analyze the association of antibiotic concentrations with obesity-related indexes. Subsequently, a gender-stratified anal. was performed. Of the included elderly, 50.7% were defined as having overweight/obesity, 59.8% as having central preobesity/obesity, and 37.5% as having slightly high/high BFP. Linear regression anal. revealed that a 1-unit increase in the logarithmic transformation of norfoxacin concentrations was related with an increase of 0.29 kg/ m² (95% CI: 0.02-0.04), 0.99 cm (95% CI: 0.24-1.75), and 0.69% (95% CI: 0.21-1.17) in BMI, WC, and BFP, resp. Compared with the control group, exposure to doxycycline (tertile 2: odds ratio, 2.06 [95% CI: 1.12-3.76]) and norfloxacin (tertile 2: 2.13 [1.05-4.29]; tertile 3: 2.07 [1.03-4.17]) had BMI-based overweight/obesity risk. Addnl., ciprofloxacin (tertile 2: 2.06 [1.12-3.76]), norfloxacin (tertile 3: 2.95 [1.34-6.49]), and florfenicol (tertile 3:1.84 [1.07-3.14]) were related to WC-based central preobesity/obesity risk. Norfoxacin (tertile 3: 2.54 [1.23-5.24]) was pos. associated with a slightly high/high BFP risk. Gender-stratified anal. demonstrated an increased adiposity risk in women compared with men. Our research provided an evidence that exposure to specific types of antibiotics (tetracyclines and fluoroquinolones) probably from the food chain contributed to obesity in elderly. Prospective cohort studies with larger sample size are warranted to explore the causation. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Electric Literature of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Electric Literature of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

An Automated Continuous-Flow Platform for the Estimation of Multistep Reaction Kinetics was written by Reizman, Brandon J.;Jensen, Klavs F.. And the article was included in Organic Process Research & Development in 2012.HPLC of Formula: 62968-37-0 This article mentions the following:

Automated continuous flow systems coupled with online anal. and feedback have been previously demonstrated to model and optimize chem. syntheses with little a priori reaction information. However, these methods have yet to address the challenge of modeling and optimizing for product yield or selectivity in a multistep reaction network, where low selectivity toward desired product formation can be encountered. Here we demonstrate an automated system capable of rapidly estimating accurate kinetic parameters for a given reaction network using maximum likelihood estimation and a D-optimal design of experiments The network studied is the series-parallel nucleophilic aromatic substitution of morpholine onto 2,4-dichloropyrimidine. To improve the precision of the estimated parameters, we demonstrate the use of the automated platform first in optimization of the yield of the less kinetically favorable 2-substituted product. Then, upon isolation of the intermediates, we use the automated system with maximum a posteriori estimation to minimize uncertainties in the network parameters. From considering the steps of the reaction network in isolation, the kinetic parameter uncertainties are reduced by 50%, with less than 5 g of the dichloropyrimidine substrate consumed over all experiments We conclude that isolating pathways in the multistep reaction network is important to minimizing uncertainty for low sensitivity rate parameters. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0HPLC of Formula: 62968-37-0).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.HPLC of Formula: 62968-37-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Design, synthesis, and biological evaluation of novel 2′-methyl-2′-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents was written by Yao, Guoqiang;Yu, Jianchen;Lin, Cai;Zhu, Yujia;Duan, Anna;Li, Mengfeng;Yuan, Jie;Zhang, Jiancun. And the article was included in European Journal of Medicinal Chemistry in 2022.HPLC of Formula: 37972-24-0 This article mentions the following:

Zika virus (ZIKV) is a mosquito-borne flavivirus and outbreaks of ZIKV have been reported in Africa, Americas and other parts of the world lately. The ZIKV epidemic has received extensive attention due to its ability to cause serious medical consequences and complications such as microcephaly and Guillain-Barre syndrome in recent years. Up to now, there are no specific treatments or vaccines available for ZIKV infection, which highlights the urgent need for developing new therapies. In this work, we designed and synthesized a series of novel 6-methyl-7-acetylenenyl-7-deazapurine nucleoside analogs as potential inhibitors of ZIKV replication. The biol. activities against ZIKV replication were evaluated and the structure-activity relationship (SAR) was also studied. Among the compounds evaluated, nucleoside analog 38 (EC50 = 2.8 ± 0.8 μM, EC90 = 6.8 ± 2.3 μM) showed the most potent anti-ZIKV activity with low cytotoxicity (CC50 = 54.1 ± 6.9 μM) in an A549 based cellular model. The inhibitory activity of 38 was about 5 times more potent than the pos. control NITD008. Notably, 38 showed similar inhibition potency against different ZIKV strains (ZG-01 and MR766) in a variety of host cell types including SNB19, A549, Huh7, Vero. In addition, 38 (Kd = 1.87 μM) has a stronger affinity to ZIKV RNA-dependent RNA polymerase (RdRp) protein than NITD008 (Kd = 3.43 μM) in the non-phosphorylation assay. These results indicated that compound 38 may serve as a promising candidate in future anti-ZIKV drug discovery. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0HPLC of Formula: 37972-24-0).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.HPLC of Formula: 37972-24-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and x-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones was written by Veale, Chris A.;Bernstein, Peter R.;Bryant, Craig;Ceccarelli, Christopher;Damewood, James R. Jr.;Earley, Roger;Feeney, Scott W.;Gomes, Bruce;Kosmider, Ben J.. And the article was included in Journal of Medicinal Chemistry in 1995.Name: 5-Aminopyrimidin-4(3H)-one This article mentions the following:

The effects of changes in substitution in a series of 5-amino-2-pyrimidin-6-ones on both in vitro elastase-inhibitory activity and oral activity in an acute hemorrhagic assay were explored. These compounds contained either a trifluoromethyl ketone or a boronic acid moiety to bind covalently to the serine-195 OH group of human leukocyte elastase (HLE). Boronic acid-containing inhibitors were more potent than the corresponding trifluoromethyl ketones in vitro but were less active upon oral administration. One compound (I; R¹ = H; Ar = 4-fluorophenyl; R² = trifluoromethyl ketone) offered the best combination of oral potency, duration of action, and enzyme selectivity and, as such, was selected for further biol. testing. X-ray crystallog. of a cocrystd. complex of another compound (I; R¹ = CH₃SO₂; Ar = 4-aminophenyl; R² = trifluoromethyl ketone) and porcine pancreatic elastase demonstrated that the inhibitor is bound to the enzyme in a manner similar to that found previously for a closely related series of pyridone-containing inhibitors of HLE. In the experiment, the researchers used many compounds, for example, 5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0Name: 5-Aminopyrimidin-4(3H)-one).

5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Name: 5-Aminopyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer was written by Wu, Zhengyang;Bai, Ying;Jin, Jiaming;Jiang, Teng;Shen, Hui;Ju, Qiurong;Zhu, Qihua;Xu, Yungen. And the article was included in European Journal of Medicinal Chemistry in 2021.Recommanded Product: 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine This article mentions the following:

PARP inhibitors have achieved great success in cancers with BRCA mutations, but only a small portion of patients carry BRCA mutations, which results in their narrow indication spectrum. Recently, emerging evidence has demonstrated that combinations of PARP and PI3K inhibitors could evoke unanticipated synergistic effects in various cancers, even including BRCA-proficient ones. In this work, a series of PARP/PI3K dual inhibitors were designed, synthesized, and evaluated for their biol. activities. It was found that compounds 9a and 23a exhibited excellent inhibitory activities against PARP-1 (9a: IC50 = 1.57 nM, 23a: IC50 = 0.91 nM) and PI3Kα (9a: IC50 = 2.0 nM, 23a: IC50 = 1.5 nM), and showed promising antiproliferative activities against both BRCA-deficient (HCT-116, HCC-1937) and BRCA-proficient (SW620, MDA-MB-231/468) tumor cells. 9a and 23a also exhibited considerable in vivo antitumor efficacy in an MDA-MB-468 xenograft mouse model, with TGI values of 56.39% and 48.77%, resp. Addnl., 23a possessed promising profiles including high kinase selectivity and low cardiotoxicity. Overall, this work indicates 9a and 23a might be potential PARP/PI3K dual inhibitors for cancer therapy and deserve further research. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine (cas: 35265-83-9Recommanded Product: 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine).

2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine (cas: 35265-83-9) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Recommanded Product: 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators was written by Chekler, Eugene L. Piatnitski;Unwalla, Rayomond;Khan, Taukeer A.;Tangirala, Raghuram S.;Johnson, Mark;St. Andre, Michael;Anderson, James T.;Kenney, Thomas;Chiparri, Sue;McNally, Chris;Kilbourne, Edward;Thompson, Catherine;Nagpal, Sunil;Weber, Gregory;Schelling, Scott;Owens, Jane;Morris, Carl A.;Powell, Dennis;Verhoest, Patrick R.;Gilbert, Adam M.. And the article was included in Journal of Medicinal Chemistry in 2014.Computed Properties of C7H6Cl2N2O2 This article mentions the following:

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biol. activity and phys. properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramol. interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating LH (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicol. study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days. In the experiment, the researchers used many compounds, for example, Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6Computed Properties of C7H6Cl2N2O2).

Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Computed Properties of C7H6Cl2N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Response of fungi-microalgae pellets to copper regulation in the removal of sulfonamides and release of dissolved organic matters was written by Li, Shuangxi;Li, Zhuo;Liu, Dongyang;Yin, Zhihong;Hu, Dan;Yu, Yunjiang;Li, Zhaohua;Zhu, Liandong. And the article was included in Journal of Hazardous Materials in 2022.Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Both sulfonamides (SAs) and copper (Cu(II)) were frequently detected together in swine wastewater. In this study, the regulation of Cu(II) on SAs adsorption and release of dissolved organic matters (DOMs) by fungi-microalgae pellets (FM-pellets) were investigated. Aspergillus oryzae pellets were prepared for combination with Chlorella vulgaris and the optimal conditions were at agitation speed of 130 rpm, fungi to microalgae ratio of 10:1 and the combined time of 3 h with the highest combination efficiency of 98.65%. The results showed that adsorption was the main mechanism for SAs removal. FM-pellets exhibited a high SAs adsorption potential within 6 h, and the adsorption capacity of sulfamethazine (SMZ), sulfamonomethoxine (SMM) and sulfamethoxazole (SMX) was 1.07, 0.94 and 1.67 mg/g, resp. Furthermore, the removal of SMX, SMZ and SMM was greatly promoted from 62.31% to 85.21%, 58.71-67.91% and 64.17-80.31%, resp., under the presence of 2 mg/L Cu(II) through ion exchange and adsorption bridging. DOMs were analyzed by the parallel factor (PARAFAC) to demonstrate the response mechanism of FM-pellets to Cu(II). Protein-like substances and NADH in DOMs released by FM-pellets formed complexes with Cu(II) to alleviate the damage on the organism. These findings provide new insights into the mechanism and response of Cu(II) in the removal of SAs by FM-pellets. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Determination of organic pollutants in water by off-line supercritical fluid extraction-gas chromatography/infrared spectrometry/mass spectrometry was written by Ren, Li;Wang, Guojun. And the article was included in Sepu in 1998.Category: pyrimidines This article mentions the following:

A supercritical fluid extraction (SFE) method using carbon dioxide for the determination of organic pollutants in Yellow River water was developed. In this paper, organic contaminants in 3L Yellow River water were concentrated on 1g GDX-301 adsorbent and then eluted from the adsorbent with supercritical CO₂. The analytes extracted by SFE were collected into 1mL alc. collecting solvent through a SiO₂ restrictor (35cm x 50μm i.d.). Finally, the collecting solvent was analyzed by Gas Chromatog./IR Spectrometry/Mass Spectrometry. The SFE conditions which were optimized for removal of the analytes from adsorbent were 20MPa, 60°C and 40min. The extraction efficiencies of SFE were directly compared to those obtained by using 15mL dichloromethane elution. Efficiencies of SFE under conditions of 20MPa, 60°C and 40min were generally higher than those of solvent elution. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Category: pyrimidines).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Occurrence of veterinary antibiotics in animal manure, compost, and agricultural soil, originating from different feedlots in suburbs of Shanghai, East China was written by Qian, Xiaoyong;Wang, Zhenqi;Zhang, Hongchang;Gu, Hairong;Shen, Genxiang. And the article was included in Environmental Monitoring and Assessment in 2022.Reference of 1220-83-3 This article mentions the following:

The present study aims to monitor and assess the occurrence of veterinary antibiotics (VAs) in animal manure, compost, and fertilized soil, originating from different large-scale feedlots. The corresponding concentrations of 39 types of VAs in 8 large-scale feedlots of pig, dairy cow, and poultry were sampled in different seasons and analyzed using LC-MS. The results indicated that 17 types, 16 types, and 5 types of VAs were detected in the swine manure, compost, and fertilized soil with the concentrations of 0.003-17.82, 0.002-9.59, and 0.004-0.007 mg kg-1 (dry matter), resp.; 3 types, 2 types, and 1 type of VAs were detected in the dairy manure, compost, and fertilized soil with the concentrations of 0.003-1.94, 0.014-0.044, and 0.025 mg kg-1 (dry matter), resp.; 7 types, 5 types, and 1 type of VAs were detected in the poultry manure, compost, and fertilized soil with the concentrations of 0.035-1.06, 0.018-0.049, and 0.019 mg kg-1 (dry matter), resp. The main antibiotic classes persisted in the animal manure and their composting product and fertilized soil were sulfonamides (SAs), macrolides (MAs), and tetracyclines (TCs). Thus, this study would help to adopt strategies in pollution control of VAs and environmental protection of agriculture. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Reference of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Reference of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A novel synthesis of guanine PDE inhibitors via tricyclic imidazopyrimidines was written by Gala, Dinesh;DiBenedetto, Donald J.;Kugelman, Max;Mitchell, Michael B.. And the article was included in Tetrahedron Letters in 2003.HPLC of Formula: 54030-56-7 This article mentions the following:

A new method for the preparation of developmental tetracyclic guanine PDE inhibitors via a common tricyclic pyrimidine intermediate is described. Nitration of 6-amino-3-methyl-2-(methylthio)-4(3H)-Pyrimidinone gave 6-amino-3-methyl-2-(methylthio)-5-nitro-4(3H)-Pyrimidinone in 80% yield. Reaction of the latter with (1R,2R)-2-aminocyclopentanol gave rel-6-amino-2-[[(1R,2R)-2-hydroxycyclopentyl]amino]-3-methyl-5-nitro-4(3H)-pyrimidinone. Cyclization of the latter gave (5aR,8aS)-rel-4-amino-1,5a,6,7,8,8a-hexahydro-1-methyl-3-nitro-2H-cyclopent[4,5]imidazo[1,2-a]pyrimidin-2-one (I) as the key intermediate for rel-N-[(5aR,8aS)-4-amino-1,5a,6,7,8,8a-hexahydro-1-methyl-2-oxo-2H-cyclopent[4,5]imidazo[1,2-a]pyrimidin-3-yl]-4-(trifluoromethyl)benzamide (65% yield from I) and rel-N-[(5aR,8aS)-4-amino-1,5a,6,7,8,8a-hexahydro-1-methyl-2-oxo-2H-cyclopent[4,5]imidazo[1,2-a]pyrimidin-3-yl]heptanamide (81% yield from I). These compounds are intermediates for guanine PDE inhibitors (6aR,9aS)-rel-5,6a,7,8,9,9a-hexahydro-5-methyl-2-[[4-(trifluoromethyl)phenyl]methyl]cyclopent[4,5]imidazo[2,1-b]purin-4(1H)-one (Sch 51866) and (6aR,9aS)-rel-2-hexyl-5,6a,7,8,9,9a-hexahydro-5-methylcyclopent[4,5]imidazo[2,1-b]purin-4(1H)-one (Sch 59498). In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7HPLC of Formula: 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.HPLC of Formula: 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia