Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides was written by Kanagarajan, V.;Thanusu, J.;Gopalakrishnan, M.. And the article was included in European Journal of Medicinal Chemistry in 2010.Formula: C16H13N3 This article mentions the following:
Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides I (R1 = H, F, Me; R2 = H, F, MeO) were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The min. inhibitory concentration tested against the same set of bacterial and fungal strains showed that I (R1 = F, R2 = H) against 閻?Hemolytic streptococcus and Klebsiella pneumoniae and I (R1 = R2 = F) against Escherichia coli and Pseudomonas had excellent antibacterial activity. Compounds I (R1 = F, R2 = H, MeO) showed inhibition against Aspergillus flavus, I (R1 = Me, R2 = F) against Microsporum gypseum, I (R1 = F, R2 = MeO) against Mucor, and compounds I (R1 = Me, R2 = MeO; R1 = R2 = F) against Rhizopus. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia