Thermodynamic Understanding of an Aza-Michael Reaction Enables Five-Step Synthesis of the Potent Integrin Inhibitor MK-0429 was written by Gupta, Anya;Condakes, Matthew L.. And the article was included in Journal of Organic Chemistry in 2021.SDS of cas: 90905-32-1 This article mentions the following:
A general strategy for the aza-Michael addition of nucleophilic heterocycles into 閻?substituted acrylates using potassium tert-butoxide as catalyst was describe . Demonstrating that the reaction is under thermodn. control underpins optimization efforts and enables rapid exploration of the substrate scope, with yields ranging from 55% to 94%. It was further leverage these lessons in a significantly shortened synthesis of MK-0429, a potent pan-integrin inhibitor previously taken into human clin. trials for the treatment of prostate cancer and osteoporosis. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1SDS of cas: 90905-32-1).
2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.SDS of cas: 90905-32-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia