Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones was written by Cui, Xue;Ma, Jianting;Zeng, Tingting;Xu, Junyu;Li, Youbin;Wang, Xuesong. And the article was included in RSC Advances in 2021.Application of 40230-24-8 This article mentions the following:
A convenient metal-free synthesis of unsym. 2-aminopyrimidines I [R1 = cyclopropyl, Ph, 4-MeC6H4, etc.; R2 = Ph, 4-ClC6H4, 4-MeOC6H4, etc.] from imidazolate enaminones had been developed. In this procedure, various structural 2-aminopyrimidines I, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represented an effective strategy toward the synthesis of unsym. 2-aminopyrimidines I. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application of 40230-24-8).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Application of 40230-24-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia