Month: August 2024

Triazine-pyrimidine based molecular hybrids: synthesis, docking studies and evaluation of antimalarial activity was written by Kumar, Deepak;Khan, Shabana I.;Ponnan, Prija;Rawat, Diwan S.. And the article was included in New Journal of Chemistry in 2014.Related Products of 62968-37-0 This article mentions the following:

A series of novel triazine-pyrimidine hybrids have been synthesized and evaluated for their in vitro antimalarial activity. Some of the compounds showed promising antimalarial activity against both CQ-sensitive and CQ-resistant strains at micromolar level with a high selectivity index. All the compounds displayed better activity (IC₅₀ = 1.32-10.70 婵炴挾鎷? than the standard drug pyrimethamine (>19 婵炴挾鎷? against the chloroquine-resistant strain W2. All the tested compounds were nontoxic against mammalian cell lines. Docking studies of the most active compounds were performed on both wild type and quadruple mutant (N51I, C59R, S108N, I164L) PfDHFR-TS using Glide to analyze the interaction of the compounds with the binding site of the protein. The binding poses of compounds I and II, having a high Glide XP score and the lowest Glide energies, show an efficient binding pattern similar to that of the DHFR substrate (dihydrofolate) in the wild type and mutant DHFR active site. The anal. of the pharmacokinetic properties of the most active compounds using ADMET prediction attests to the possibility of developing compound I as a potent antimalarial lead. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Related Products of 62968-37-0).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 62968-37-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Investigation of the reaction of 6-amino-3-methyl-4-oxo-3,4-dihydro-2-pyrimidinylhydrazine was written by Moustafa, M. A.;Gineinah, M. M.;Bayomi, S. M.;Ismaiel, A. M.. And the article was included in Archives of Pharmacal Research in 1990.Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:

The hydrazine derivative I was utilized for the synthesis of three different fused 1,2,4-triazolo [4,3-a]pyrimidine derivatives II (R = H, R¹ = C₆H₄Cl-p, SH; R = CHO, R¹ = H) and a tetrazolo[1,5-a]pyrimidine derivative III. Reaction of I with the chalcone analog 2-thenylidene-2′-acetothienone, gave the pyrazoline derivative IV. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia