Adding a certain compound to certain chemical reactions, such as: 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C12H12Cl2N3OP, blongs to pyrimidines compound. Formula: C12H12Cl2N3OP
A suspension of 2(1.27g, 4.0 mmol), 3-Boc-amino-5-methoxyaniline(965mg, 4.0mmol), palladium acetate(133mg, 0.59mmol), XantPhos(352mg, 0.61 mmol) and potassium phosphate(1.4g, 6.6mmol) in anhydrous DMF(35 mL) was heated at 120 C overnight. After the reaction was cooling to room temperature, ethyl acetate was added to dilute the reaction and the content was filtered through celite. Solvent was removed under vacuum. The residue was purified by flash column chromatography on silica gel to give pure product 1.3g (yield 62%) as a tan solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, and friends who are interested can also refer to it.
Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; ZHU, Xiaotian; WANG, Yihan; SHAKESPEARE, William, C.; HUANG, Wei-Sheng; DALGARNO, David, C.; WO2013/169401; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia