In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H7ClN2O2
4-(furan-2-yl)-2,6-dimethoxypyrimidine According to the general procedure, a mixture of 6-chloro-2,4-dimethoxypyrimidine (175 mg, 1 .00 mmol), 2-furanboronic acid (168 mg, 1 .50 mmol), (7i-crotyl)Pd(XPhos)CI (14 mg, 0.02 mmol), 2 mL THF, and 4 mL of 0.5 M aqueous K3P04 are stirred at room temperature for 1 hour. The crude material is chromatographed on silica gel with a gradient of 0 – 10 % EtOAc/hexanes as the eluent to give 194 mg (0.94 mmol, 94 %) of 4-(furan-2-yl)-2,6-dimethoxypyrimidine as a colorless solid. H NMR (400 MHz, CDCI3, delta): 7.53 (dd, J = 0.9 Hz, 1 .9 Hz, 1 H), 7.19 (dd, J = 0.7 Hz, 3.5 Hz, 1 H), 6.69 (s, 1 H), 6.53 (dd, J = 1 .7 Hz, 3.4 Hz, 1 H) 4.02 (s, 3H), 3.99 (s, 3H). l3C NMR (100 MHz, CDCI3, delta): 172.6, 165.6, 157.4, 152.2, 144.6, 1 12.3, 1 1 1 .9, 95.0, 54.8, 54.0. Anal. Calcd. for C10H10N2O3: C, 58.25; H, 4.89; N, 13.59. Found: C, 58.19; H, 4.72; N, 13.42
The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; COLACOT, Thomas; CHOW, Ruishan; JON DEANGELIS, Andrew; WO2015/189554; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia