Reference of 145783-15-9, Adding some certain compound to certain chemical reactions, such as: 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine,molecular formula is C7H9Cl2N3S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 145783-15-9.
Compound (1-1) (476 mg, 2.0 mmol), hydrochloric salt of compound (2?) (524 mg, 2.2 mmol) and NaHCO3 (370 mg, 4.4 mmol) were added to DMF (20 ml). Under the nitrogen atmosphere, the reaction mixture was stirred for 12-15 hours at 90-95 . The reaction was monitored by TLC. After completion, water (100 ml) and CH2Cl2 (100 ml) were added to the reaction mixture. The resulting mixture was stirred for 30 min, followed by the separation of the aqueous and organic layers. The dichloromethane layer was washed with water (20 ml*3) until to neutral. The resulting organic layer was dried with anhydrous sodium sulfate, and then filtered. The filtrate was removed by distillation at reduced pressure to obtain crude product (compound (1-c?)). The crude product was crystallized from the mixture of dichloromethane and petroleum ether to obtain a white solid (656 mg, yield 82.0%). HPLC purification is above 98%. (0094) 1HNMR (400 MHz, CDCl3) delta: 6.81 (b, 2H), 4.62-4.72 (m, 2H), 4.51-4.53 (m, 1H), 3.95 (d, J=7.6 Hz, 1H), 3.67-3.82 (m, 3H), 3.63-3.64 (m, 1H), 3.03-3.22 (m, 2H), 2.30-2.33 (m, 1H), 1.92-1.95 (m, 1H), 1.73-1.82 (m, 2H), 1.09 (t, J=7.6 Hz, 3H), MS (m/z): [M+H]+=405.86.
According to the analysis of related databases, 145783-15-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRIGHTGENE BIO-MEDICAL TECHNOLOGY (SUZHOU) CO., LTD; YUAN, Jiandong; JIANG, Qiao; LI, Xiang; US2015/322071; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia