Reference of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.
To a stirred solution of Intermediate 2 (1 g, 4.2 mmcl) in dry DMF (10 mL), Et3N (2.3 mL, 16.8 mmcl) and 2-chloro-5-nitropyrimidine (0.74 g, 4.6 mmcl) were added at rt and the resulting mixture was stirred at 120 °C for 20 h. It was diluted with water andextracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and concentrated under vacuum. The resulting crude product was purified by flash chromatography to give the title compound (yellow solid). 1H NMR (400 MHz, DMSOd 6): 6 9.08 (s, 2H), 6.92 (s, I H), 6.85-6.83 (m, I H), 6.77 (s, I H), 5.98 (m, 2H), 3.89 (s, 4H), 3.50 (s, I H), 2.45-2.44 (m, 4H), 1.30 (br s, 3H). LCMS: (Method A) 358.0 (M+H), Rt. 3.00 mm, 94.23percent (Max).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10320-42-0, 2-Chloro-5-nitropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; TORONTO, Dawn, V.; CROWE, David, Malcolm; (150 pag.)WO2017/144637; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia