Synthetic Route of 163622-50-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 163622-50-2, name is 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine. A new synthetic method of this compound is introduced below.
4-amino-5-iodo-weighed -7H- pyrrolo [2,3-d] pyrimidine (2g, 0.0077mol)And potassium carbonate (4.2 g, 0.0310 mol),After adding DMF (50mL) dissolved and heated to 90 reflux,N-Butyl iodide (2 mL) was added dropwise to the solution using a separatory funnel.After 3 hours of reaction, the solvent was evaporated, extracted with ethyl acetate,The organic phase was dried over anhydrous sodium sulfate and evaporated under reduced pressure.And purified by column chromatography to give 1.80 g of a white solid (74% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,163622-50-2, 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; Sichuan University Huaxi Hospital; He Yang; Chai Yingying; Chen Bojiang; Zhou Xinglong; Li Changfu; Qiu Zhixin; Li Weimin; (11 pag.)CN106831790; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia