The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32779-36-5, name is 5-Bromo-2-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Bromo-2-chloropyrimidine
The subtitle compound was prepared following a method by Takahashi et al., Chem.Pharm. Bull, 1958, 6, 334-337. To a solution of 5-bromo-2-chloropyrimidine (1.0 g, 5.2mmol) in EtOH was added sodium methanethiolate (0.36 g, 5.2 mmol) at roomtemperature and the reaction mixture was stirred overnight. The mixture was partitionedbetween EtOAc (15 mL) and water (10 mL). The aqueous layer was extracted twice withEtOAc and washed with brine. The combined organic layers were dried and concentratedto give the subtitle compound as a white solid (1.1 g).^-NMR (CD3OD): 5 8.66 (2H, s); 2.54 (3H, s).APCI-MS m/z: 204/206 1:1 [MH+].
With the rapid development of chemical substances, we look forward to future research findings about 32779-36-5.
Reference:
Patent; ASTRAZENECA AB; WO2006/4532; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia