Synthetic Route of 3073-77-6 , The common heterocyclic compound, 3073-77-6, name is 2-Amino-5-nitropyrimidine, molecular formula is C4H4N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
5-Nitropyrimidin-2-amine (1 eq), Boc2O (1.2 eq), 4-dimethylaminopyridine(0.2eq) were added to a flask under nitrogen atmosphere and dichloromethaneat room temperature. The mixture was stirred at room temperature overnight.Ethyl acetate was added and a precipitated formed was filtered and washedwith ethyl acetate to obtain the desired tert-butyl (5-nitropyridin-2-yl)carbamate.(Crude contains approximately 20% of tert-butyl (5-nitropyrimidin-2- yl)dicarbamate mixture. Was used in the next step without purification).HPLC-MS (method A): Rt= 2.83 mm, [M+H] m/z: 241.Yield: 78%.
The synthetic route of 3073-77-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MINORYX THERAPEUTICS S.L.; GARCIA COLLAZO, Ana Maria; MARTINELL PEDEMONTE, Marc; REVES VILAPLANA, Marc; LAVILLA GRIFOLS, Rodolfo; RODRIGUEZ PASCAU, Laura; CUBERO JORDA, Elena; (136 pag.)WO2016/120808; (2016); A1;,
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