Application of 270912-79-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 270912-79-3, name is 2-((5-Bromopyrimidin-2-yl)oxy)acetic acid. A new synthetic method of this compound is introduced below.
Solid 3,4-methoxyphenylboronic acid (1.22 g, 6.72 mmol, 1.05 equiv) was added to a solution of (5-bromopyrimidin-2-yloxy)acetic acid 3e (1.5 g, 6.4 mmol) in 1-propanol (50 mL). The suspension was stirred until all ingredients had dissolved. The resulting solution was treated with Pd(OAc)2 (29 mg, 0.13 mmol, 0.02 equiv), PPh3 (103 mg, 0.39 mmol, 0.06 equiv), 2M Na2CO3 (12 mL, 24 mmol, 3.8 equiv), and deionized water (10 mL). The mixture was heated at reflux under N2 for 1 h. Additional water (20 mL) was added and the N2 inlet removed. After cooling to rt, the solution was acidified with 4M HCl. The resulting precipitate was filtered, washed with cold diluted HCl, and dried under vacuum to give 5-(3,4-dimethoxyphenyl)-pyrimidin-2-yloxy)acetic acid 3f as a brown solid (1.30 g, 70%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,270912-79-3, 2-((5-Bromopyrimidin-2-yl)oxy)acetic acid, and friends who are interested can also refer to it.
Reference:
Patent; Du Bois, Daisy Joe; Mao, Long; Rogers, Daniel Harry; Williams, John Patrick; US2004/14775; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia