In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one, the common compound, a new synthetic route is introduced below. Safety of 2-(Methylthio)pyrimidin-4(3H)-one
EXAMPLE 8 4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[2-(3,4-dihydro-4-oxo-pyrimidin-2-ylamino)ethoxymethyl]-1,4-dihydropyridine STR32 2-[2-Aminoethoxymethyl]-3-ethoxycarbonyl-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (0.75 g) and 2-methylthio-3H-pyrimid-4-one (0.5 g) were dissolved in ethanol (5 ml) and heated under reflux for 20 hours. The solvent was evaporated and the residue was partitioned between ethyl acetate and water. The organic layer was separated, washed with 2N hydrochloric acid to remove any unreacted amine, and then with dilute sodium hydroxide solution. It was then washed with water, dried, filtered and evaporated to give a yellow gum. Chromatography on silica “Kieselgel 60H” (Trade Mark) eluding with ethyl acetate gave the title compound, which was recrystallized from ethyl acetate, yield 171 mg, m.p. 148°-150°. Analysis percent: Found: C, 57.3; H, 5.55; N, 11.4. Calculated for C24 H27 ClN4 O6: C, 57.3; H, 5.4; N, 11.15.
The synthetic route of 5751-20-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer Inc.; US4572908; (1986); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia