Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24391-41-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
General procedure: To a mixture of ArCl (22.92 mmol) and piperidinederivative (27.5 mmol, 1.2 eq) in Water/DMSO (35 mL/35 mL) was added DIPEA(32.0 mL, 183 mmol, 8 eq). The resulting mixture was refluxed overnight andcooled to room temperature. The suspension was diluted with H2O (500ml) and neutralized by dropwise addition of concentrated aqueous HCl to pH 6.3.The solid was collected by filtration and washed with H2O. The solidwas then dissolved in 1M aqueous NaOH (200 ml) and filtered. The filtrate wasneutralized by dropwise addition of concentrated HCl to pH 6.7, resulting in abeige precipitation. The solid was collected by filtration and washed with H2O,ACN (2x) and Et2O. The obtained powder was suspended in ACN andfreeze-dried to afford the desired intermediate, which was used for the nextstep without further purification.
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Reference:
Article; Boland, Sandro; Bourin, Arnaud; Alen, Jo; Geraets, Jacques; Schroeders, Pieter; Castermans, Karolien; Kindt, Nele; Boumans, Nicki; Panitti, Laura; Vanormelingen, Jessica; Fransen, Silke; Van De Velde, Sarah; Defert, Olivier; Bioorganic and Medicinal Chemistry Letters; vol. 25; 18; (2015); p. 4005 – 4010;,
Pyrimidine | C4H4N2 – PubChem,
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