Synthetic Route of 3740-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In 250mL three-necked flask, purged with nitrogen, was added 0.01mol intermediate A20, 150mlDMF, 0.012mol intermediate B1, 0.0001mol palladium acetate, stirred,Then 0.01mol K3PO4 aqueous solution was added, heated to 150 , the reaction was refluxed for 24 hours, the sample point plate, the reaction was complete.The mixture was naturally cooled and extracted with 200 ml of dichloromethane. The layers were separated and the extract was dried over anhydrous sodium sulfate and filtered. The filtrate was rotary evaporated and purified over silica gel to give intermediate C1. HPLC purity was 99.2percent with a yield of 85.1percent.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Zhang Zhaochao; Li Chong; (51 pag.)CN107417668; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia