Related Products of 1421372-67-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1421372-67-9, name is N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine, molecular formula is C25H29N7O3, molecular weight is 475.5429, as common compound, the synthetic route is as follows.
A solution of N1- (2- (dimethylamino) ethyl) -5-methoxy-N1-methyl-N4- (4- (1-methylindol-3-yl) 2-nitrophenyl-1,4-diamine (30.0 g, 0.063 mol) was added to a 1 L vial,Adding 600 mL of tetrahydrofuran and 10 g of Raney nickel,Hydrogen gas at a pressure of 3 atm was introduced at room temperature,Reaction for 12 h.After the reaction is complete,The reaction solution was filtered through celite,To obtain a brown solution,Concentrated under reduced pressure to give crude brown solid,The crude product was purified by recrystallization from 250 mL of a mixture of ethyl acetate and n-heptane (1: 1 by volume of ethyl acetate and n-heptane in the mixture)To give a light brown solid N1- (2- (dimethylamino) ethyl) -5-methoxy -N1- methyl -N4- (4- (1- methyl-indol-3-yl) pyrimidine-2 – yl) phenyl-1,2,4-triamine 21.9g, yield 78%.
Statistics shows that 1421372-67-9 is playing an increasingly important role. we look forward to future research findings about N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine.
Reference:
Patent; Shanghai University of Engineering Science; Zhu, Guoqing; Mao, Yongjun; Zhu, Chunping; Wang, Han; (16 pag.)CN106366072; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
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