Electric Literature of 3934-20-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3934-20-1, name is 2,4-Dichloropyrimidine, molecular formula is C4H2Cl2N2, molecular weight is 148.9781, as common compound, the synthetic route is as follows.
A stirred solution of 2,4-dichloropyrimidine (5.00g, 36.5mmol) and diisopropylethylamine (14.0ml, 80.4mmol) in EtOH (60ml) at 0C was treated with morpholine (3.18ml, 36.5mmol) and allowed to warm to ambient temperature overnight. The solution was poured into brine and extracted with DCM. The organics were dried (MgS04), filtered and evaporated. The residue was purified by column chromatography (Si02, 5% EtOH in DCM) to afford the title compound IIIc as a white solid (1.3g, 36%). XH NMR (300 MHz, DMSO-d6) delta 8.10 (d, J = 6.2 Hz, 1H), 6.83 (d, J = 6.2 Hz, 1H), 3.72 – 3.49 (m, 8H).
The chemical industry reduces the impact on the environment during synthesis 3934-20-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; AB SCIENCE; BENJAHAD, Abdellah; MARTIN, Jason; SCHALON, Claire; PEZ, Didier; CHEVENIER, Emmanuel; SANDRINELLI, Franck; PICOUL, Willy; MOUSSY, Alain; WO2015/144614; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
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