Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 26452-81-3, name is 4-Chloro-6-methoxypyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C5H5ClN2O
To a solution of (S)isopropyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-2,6-dimethyl-5-( 1,2,3,4- tetrahydroisoquinolin-6-yl)pyridin-3-yl)acetate, 2 HC1 (0.0 15 g, 0.024 mmol) and 4- chloro-6-methoxypyrimidine (0.01 g, 0.069 mmol) in ACN (0.5 mL) was addedpotassium carbonate (0.02 g, 0.145 mmol) and heated at 100 °C for 18 h in a sealed vial. Then, cooled, filtered off the solid, removed the solvent and treated with EtOH (1 ml)sodium hydroxide (0.975 mg, 0.024 mmol). The resulting mixture was heated at 85for 3 h and purified by prep HPLC to afford (S)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-5-(2- (2-methoxypyrimidin-4-yl)- 1,2,3 ,4-tetrahydroi soquinolin-6-yl)-2,6-dimethylpyridin-3yl)acetic acid (0.0077 g, 0.013 mmol, 51.4 percent yield). LCMS (M+H) = 609.4.
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Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; TU, Yong; (133 pag.)WO2017/29631; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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