Application of 33089-15-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33089-15-5, name is 4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below.
Method 65 4-Anilino-5-cyano-2-(methylthio)pyrimidine Using a method analogous to that described in Method 7, but starting from 4-chloro-5-cyano-2-(methylthio)pyrimidine (obtained as described in J. Het. Chem. 1971, 8, 445) and performing the reaction at 85 C., the product was obtained in 93% yield. NMR (CDCl3): 2.51 (s, 3H), 7.15 (br s, 1H), 7.20 (t, 1H), 7.40 (dd, 2H), 7.57 (d, 2H), 8.38 (s, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,33089-15-5, 4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; AstraZeneca AB; US6593326; (2003); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia