Application of 1448307-66-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1448307-66-1, name is 1-(2-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde, molecular formula is C9H7ClN4O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A stirred suspension of commercially available l-(2-chloro-4-pyrimidinyl)-3-methyl- lH-pyrazole-4-carbaldehyde (222 mg, 1.0 mmol) and 3-azetidinol hydrochloride (219 mg, 2.0 mmol) in dichloromethane (10 mL) was treated with triethylamine (700 muTau, 5.0 mmol) followed by portionwise addition of Na(OAc)3BH (636 mg, 3.0 mmol). The resulting mixture was stirred at room temperature overnight. Next morning, LCMS indicated clean conversion to product. The reaction mixture was transferred to a separately funnel, diluted with dichloromethane, washed with saturated aqueous NaHC03 solution. The organic layer was dried over anhydrous MgS04, filtered and concentrated in vacuo. The crude product was obtained as a white foam (185 mg, 0.66 mmol, 66%) and used directly in the next step. LC/MS – HPLC (254 nm) – Rt 1.04 min. MS (ESI) m/z 280.5 [M+ + H+]. Purity = 95 % by UV (254 nm).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1448307-66-1, 1-(2-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde.
Reference:
Patent; SIGNALRX PHARMACEUTICALS, INC.; MORALES, Guillermo, A.; GARLICH, Joseph, R.; DURDEN, Donald, L.; (155 pag.)WO2018/226739; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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