Reference of 7752-82-1 ,Some common heterocyclic compound, 7752-82-1, molecular formula is C4H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A sealed tube is charged with [5-[[[8-(1-methylindol-6-yl)quinoxalin-6- yl]amino]methyl]-3-pyridyl]boronic acid (Intermediate 25) (130.00 mg; 0.20 mmol; 1.00 eqf.), 5-bromopyrimidin-2-ylamine (37.70 mg; 0.22 mmol; 1.10 eqf.), solution of 2M Na2C03 (0.30 mL; 0.59 mmol; 3.00 eqf.), EtOH (2.00 mL) and toluene (2.00 mL). RM is purged with argon and then Pd(PPh3)4 (22.76 mg; 0.02 mmol; 0.10 eqf.) is added. The resulting mixture is heated at 120C for 24 h. After this time, the mixture is diluted with EtOAc. The organic layer is washed with water, brine, dried over MgSO4 and evaporated. The residue is purified by FCC (EtOAc/MeOH; gradient). N-{[5-(2-Aminopyrimidin-5- yl)pyridin-3-yl]methyl}-8-(1 -methyl- 1 H-indol-6-yl)quinoxalin-6-amine (64.00 mg; yield 65.1 %; 92 % by HPLC) is obtained as a yellow powder.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7752-82-1, 5-Bromopyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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