In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, the common compound, a new synthetic route is introduced below. Formula: C5HCl3N2O
To a solution of 2,6-dichloropyrimidine-4-carbonyl chloride (1-158) (500 mg, 2.37 mmol), and TEA (718 mg, 7.1 1 mmol) in CH2CI2 (30 ml_) was added (2R)-2-aminopropyl benzoate hydrochloride (354 mg, 1 .98 mmol) in portions at 0 C under a nitrogen atmosphere, and the mixture was stirred at 0 ~ 10 C for 1 hr. TLC (EtOAc) showed the reaction was completed. The mixture was quenched with H20 (20 ml_) and extracted with CH2CI2 (2 x 50 ml_). The combined organic layers were washed with brine (3 x 30 ml_), dried over Na2S04 and concentrated. The residue was purified by silica gel chromatography (petroleum ether/EtOAc = 6/1 , Rf = 0.4) to give (2R)-2-{[(2,6-dichloropyrimidin-4-yl)carbonyl]amino}propyl benzoate (1-182) (3S5 mg, 46%) as an oil, which was used without further purification.
The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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