Adding a certain compound to certain chemical reactions, such as: 10320-42-0, 2-Chloro-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 10320-42-0, blongs to pyrimidines compound. HPLC of Formula: C4H2ClN3O2
EXAMPLE 47; (S)-2-(4-Chlorophenyl)-5-(2-(3-(methylamino)pyrrolidin-l-yl)pyrimidin-5-yl)-4,5- dihydropyrrolo[3,4-c]pyrazol-6(2H)-one; Example 47 A. (5)-N-Methyl- 1 -(5 -nitropyrimidin-2-yl)pyrrolidin-3 -amine; [00229] (S)-N-Methylpyrrolidin-3 -amine (286 mg, 2.86 mmol) was added to 2- chloro-5-nitropyrimidine (415 mg, 2.60 mmol) slowly (CAUTION: extreme exotherm. . .). The resulting mixture was heated at 110 0C for 10 min. After cooling down to room temperature, another portion of amine (0.100 g) was added to the reaction mixture. The resulting mixture was heated at 110 0C for 10 min. After cooling down to room temperature, the obtained black solid product (Example 47A) was used for next step without further purification. LCMS (ES): m/z 252.3 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10320-42-0, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DEVASTHALE, Pratik; WASHBURN, William, N.; WANG, Wei; HERNANDEZ, Andres; AHMAD, Saleem; ZHAO, Guohua; WO2010/47956; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia