Reference of 54326-16-8 , The common heterocyclic compound, 54326-16-8, name is 5-Chloropyrimidin-2(1H)-one, molecular formula is C4H3ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 25 5-Chloro-1-(4-cyanophenacyl)pyrimidin-2-one A suspension of 5-chloropyrimidin-2-one (412 mg) and 2-bromo-4′-cyanoacetophenone (677 mg) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for one hour. Water (100 ml) was added and the collected solid was crystallized from ethyl acetate to give the title pyrimidinone (375 mg,); m.p. 236-240; lambdamaxEtOH 248 nm (epsilon 26140), 289 nm (epsilon 2130), lambdainf 254 (epsilon 22800).
The synthetic route of 54326-16-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Glaxo Group Limited; US4636509; (1987); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia