Synthetic Route of 1780-40-1 ,Some common heterocyclic compound, 1780-40-1, molecular formula is C4Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 2,4,5,6-tetrachloropyrimidine (5 g, 22.9 mmol) in THF (50 mL) was added iN NaOH (31 mL, 31.2 mmol) dropwise, and the mixture was stirred overnight at RT. The solution was acidified with iN HC1 and extracted with DCM (3x). The organics were combined, dried, and concentrated in vacuo. The solids were slurried in Et20 for 30 mm at RT, filtered, washed with Et20, and dried to give 3.0 g (66%) of the title compound. [M+H] Calc?d for C4HC13N2O, 201; Found, 201.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1780-40-1, 2,4,5,6-Tetrachloropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; CHEN, Young, K.; KANOUNI, Toufike; KALDOR, Stephen, W.; STAFFORD, Jefrey, Alan; VEAL, James, Marvin; WO2015/168466; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia