Reference of 89581-38-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89581-38-4, name is Methyl 5-bromopyrimidine-2-carboxylate, molecular formula is C6H5BrN2O2, molecular weight is 217.0201, as common compound, the synthetic route is as follows.
To the reaction flask were added 1 mmol of compound F55, N, N-dimethylglycine, cuprous iodide, Cs2CO3, 1, 4-Dioxane and 2 mmol of 5-bromo-2-pyrimidinecarboxylic acid methyl ester, heating under nitrogen to 80 C for 24 h,Water, extracted with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and purified on a silica gel column(Eluent: petroleum ether: ethyl acetate = 1: 1) to give the title product as a pale yellow oily liquid.
The chemical industry reduces the impact on the environment during synthesis 89581-38-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Guangdong Zhongsheng Pharmaceutical Co., Ltd.; Chen, Lijuan; Long, Chaofeng; Chen, Xiaoxin; Liu, Zhuowei; Ye, Haoyu; Xie, Chengshi; (104 pag.)CN106045923; (2016); A;,
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